Preclinical Comparison of 111InIn- and 225AcAc-DOTA-Trastuzumab IgG, F(ab')2 and Fab for Theranostic SPECT/CT Imaging and α-Particle Radioimmunotherapy of HER2-Positive Human Breast Cancer

Radioimmunotherapy (RIT) with α-particle-emitting, 225Ac complexed to trastuzumab may offer an alternative treatment for patients who progress on HER2-targeted therapies. Moreover, RIT with [225Ac]Ac-DOTA-trastuzumab could be combined with SPECT/CT imaging with [111In]In-DOTA-trastuzumab in a theran...

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Veröffentlicht in:	Molecular pharmaceutics 2025-01, Vol.22 (1), p.474
Hauptverfasser:	Kondo, Misaki, Cai, Zhongli, Chan, Conrad, Brown, Madeline K, Reilly, Raymond M
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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