CircFAM64A(3) promoted bladder cancer proliferation and inhibited CD8 + T cell via sponging to miR-149-5p and activated IL-6/JAK/STAT pathway

[Display omitted] •CircFAM64A(3) was upregulated in bladder cancer.•CircFAM64A(3) promoted bladder cancer cells proliferation and immune evasion.•CircFAM64A(3) active the JAK/STAT pathway through IL-6.•HIF-1α/circFAM64A/miR-149-5p/IL-6 axis was an important regulatory pathway. The significance of ci...

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Veröffentlicht in:	International immunopharmacology 2025-01, Vol.145, p.113762, Article 113762
Hauptverfasser:	Zhuang, Juntao, Zhou, Ming, Yu, Hao, Zhou, Rui, Bai, Kexin, Lv, Jiancheng, Li, Kai, Cheng, Yidong, Yang, Haiwei, Yang, Xiao, Lu, Qiang
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bladder cancer CD8-Positive T-Lymphocytes - immunology Cell Line, Tumor Cell Proliferation circFAM64A Female Gene Expression Regulation, Neoplastic Humans Hypoxia-Inducible Factor 1, alpha Subunit - genetics Hypoxia-Inducible Factor 1, alpha Subunit - metabolism IL-6 Immune evasion Interleukin-6 - genetics Interleukin-6 - metabolism JAK/STAT Janus Kinases - metabolism Male Mice Mice, Inbred BALB C Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism Proliferation RNA, Circular - genetics RNA, Circular - metabolism Signal Transduction STAT Transcription Factors - metabolism Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - immunology Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology
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