Skin immune-mesenchymal interplay within tertiary lymphoid structures promotes autoimmune pathogenesis in hidradenitis suppurativa

Hidradenitis suppurativa (HS) is a chronic, debilitating inflammatory skin disease characterized by keratinized epithelial tunnels that grow deeply into the dermis. Here, we examined the immune microenvironment within human HS lesions. Multi-omics profiling and multiplexed imaging identified tertiar...

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Veröffentlicht in:	Immunity (Cambridge, Mass.) Mass.), 2024-12, Vol.57 (12), p.2827-2842.e5
Hauptverfasser:	Yu, Wei-Wen, Barrett, Joy N.P., Tong, Jie, Lin, Meng-Ju, Marohn, Meaghan, Devlin, Joseph C., Herrera, Alberto, Remark, Juliana, Levine, Jamie, Liu, Pei-Kang, Fang, Victoria, Zellmer, Abigail M., Oldridge, Derek A., Wherry, E. John, Lin, Jia-Ren, Chen, Jia-Yun, Sorger, Peter, Santagata, Sandro, Krueger, James G., Ruggles, Kelly V., Wang, Fei, Su, Chang, Koralov, Sergei B., Wang, Jun, Chiu, Ernest S., Lu, Catherine P.
Format:	Artikel
Sprache:	eng
Schlagworte:	Autoimmunity B-Lymphocytes - immunology CCL19 Chemokine CCL19 - metabolism Chemokine CXCL13 - metabolism CXCL13 Fibroblasts - immunology Fibroblasts - metabolism hidradenitis suppurativa Hidradenitis Suppurativa - immunology Humans inflammatory fibroblast Keratinocytes - immunology Keratinocytes - metabolism lymphocyte clonal expansion single-cell transcriptomics single-cell VDJ sequencing Skin - immunology Skin - pathology tertiary lymphoid structure Tertiary Lymphoid Structures - immunology TLS TLS on a chip TNF blockade Tumor Necrosis Factor-alpha - metabolism
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