Combined training and hormones/enzymes with insulinotropic actions in individuals with overweight and type 2 diabetes mellitus: A randomized controlled trial
The incretins (glucose‐dependent insulinotropic polypeptide [GIP] and glucagon‐like peptide‐1 [GLP‐1]), along with amylin/islet amyloid polypeptide (IAPP) and insulin‐degrading enzyme (IDE), are hormones/enzymes that have been pharmacological targets, such as dipeptidyl peptidase‐4 (DPP‐4) inhibitor...
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| creator | Bonfante, Ivan Luiz Padilha Duft, Renata Garbellini Mateus, Keryma Chaves da Silva Trombeta, Joice Cristina dos Santos Chacon‐Mikahil, Mara Patricia Traina Velloso, Licio Augusto Cavaglieri, Cláudia Regina |
| description | The incretins (glucose‐dependent insulinotropic polypeptide [GIP] and glucagon‐like peptide‐1 [GLP‐1]), along with amylin/islet amyloid polypeptide (IAPP) and insulin‐degrading enzyme (IDE), are hormones/enzymes that have been pharmacological targets, such as dipeptidyl peptidase‐4 (DPP‐4) inhibitors, due to their insulinotropic actions. Physical training is recommended as a treatment for type 2 diabetes mellitus (T2DM); however, its effects on the concentrations of these hormones/enzymes are not well known. Thus, the present study aimed to evaluate the effects of combined training (CT) on the concentrations of hormones/enzymes with insulinotropic actions in individuals with T2DM and overweight. Individuals of both sexes with T2DM (age 51.73 ± 4.19 years; body mass index [BMI] 29.46 ± 3.39 kg/m2) were randomly distributed in the control group (CG, n = 17) and the combined training group (CTG, n = 17). The CT consisted of strength followed by erobic training, 3 times/week, for 16 weeks. Functional variables, body composition, and serum biochemical analyses (clinical markers, GLP‐1, GIP, DPP‐4, amylin/IAPP, and IDE) were evaluated. The CTG showed a decrease in GLP‐1 (pre: 32.8 ± 12.1, post: 28.4 ± 13.5, and p = 0.04) in the group/time analysis. In the evaluation of the Δ% of variation, CTG presented a decrease for GLP‐1 (−9.3%; p = 0.03) and amylin/IAPP (−13.4%; p |
| doi_str_mv | 10.1002/ejsc.12057 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3146629699</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3146629699</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3527-a9dafa51be5b2caea554dfa1b53f3f5c350290b0d464affae96e226dd28036213</originalsourceid><addsrcrecordid>eNp9kctqGzEUhkVpaS7tpg9QBN2EwiS6jGSru2DStCWQRdu10IzOxMfMSK40E-O8S981iu12kUVAIHH49PFzfkI-cHbOGRMXsMrtORdMzV6RY66krmbCsNflPat1xaXhR-Qk5xVjZSDmb8mRNFqXr-aY_F3EocEAno7JYcBwR13wdBnTEAPkCwgP2wEy3eC4pBjy1GOIY4prbKlrR4whl3E5Hu_RT64_oPEe0gbwbjnufON2DVRQj66BsegG6Hscp_yFXtJUgDjgQ8nQxlDcfb-Lg65_R950RQnvD_cp-f316tfiW3Vze_19cXlTtVKJWeWMd51TvAHViNaBU6r2neONkp3sVIFYWUjDfK1r13UOjAYhtPdizqQWXJ6Ss713neKfCfJoB8xtyegCxClbyWuthdHGFPTTM3QVpxRKOiuZYWrOjdGF-ryn2hRzTtDZdcLBpa3lzD6VZp9Ks7vSCvzxoJyaAfx_9F9LBeB7YIM9bF9Q2asfPxd76SOJiKXg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3090581996</pqid></control><display><type>article</type><title>Combined training and hormones/enzymes with insulinotropic actions in individuals with overweight and type 2 diabetes mellitus: A randomized controlled trial</title><source>MEDLINE</source><source>PubMed Central Open Access</source><source>Taylor & Francis</source><source>Wiley Online Library Open Access</source><source>PubMed Central</source><source>Alma/SFX Local Collection</source><creator>Bonfante, Ivan Luiz Padilha ; Duft, Renata Garbellini ; Mateus, Keryma Chaves da Silva ; Trombeta, Joice Cristina dos Santos ; Chacon‐Mikahil, Mara Patricia Traina ; Velloso, Licio Augusto ; Cavaglieri, Cláudia Regina</creator><creatorcontrib>Bonfante, Ivan Luiz Padilha ; Duft, Renata Garbellini ; Mateus, Keryma Chaves da Silva ; Trombeta, Joice Cristina dos Santos ; Chacon‐Mikahil, Mara Patricia Traina ; Velloso, Licio Augusto ; Cavaglieri, Cláudia Regina</creatorcontrib><description>The incretins (glucose‐dependent insulinotropic polypeptide [GIP] and glucagon‐like peptide‐1 [GLP‐1]), along with amylin/islet amyloid polypeptide (IAPP) and insulin‐degrading enzyme (IDE), are hormones/enzymes that have been pharmacological targets, such as dipeptidyl peptidase‐4 (DPP‐4) inhibitors, due to their insulinotropic actions. Physical training is recommended as a treatment for type 2 diabetes mellitus (T2DM); however, its effects on the concentrations of these hormones/enzymes are not well known. Thus, the present study aimed to evaluate the effects of combined training (CT) on the concentrations of hormones/enzymes with insulinotropic actions in individuals with T2DM and overweight. Individuals of both sexes with T2DM (age 51.73 ± 4.19 years; body mass index [BMI] 29.46 ± 3.39 kg/m2) were randomly distributed in the control group (CG, n = 17) and the combined training group (CTG, n = 17). The CT consisted of strength followed by erobic training, 3 times/week, for 16 weeks. Functional variables, body composition, and serum biochemical analyses (clinical markers, GLP‐1, GIP, DPP‐4, amylin/IAPP, and IDE) were evaluated. The CTG showed a decrease in GLP‐1 (pre: 32.8 ± 12.1, post: 28.4 ± 13.5, and p = 0.04) in the group/time analysis. In the evaluation of the Δ% of variation, CTG presented a decrease for GLP‐1 (−9.3%; p = 0.03) and amylin/IAPP (−13.4%; p < 0.01), in addition to an increase for DPP‐4 (6.2%; p = 0.04) enzyme. CT decreases the baseline levels of important hormones with insulinotropic actions in individuals with T2DM and overweight. The improvement in overall metabolism provided by CT must be the main reason for these effects. These results broaden the understanding of the effects and relationships between CT and glucose metabolism.
Highlights
In addition to the well‐known effects of exercise training on glycemic control, trained type 2 diabetes patients can obtain positive effects on other hormones and enzymes with insulinotropic actions.
Global metabolic benefits provided by combined training induce different effects on GLP1 and DPP4 those induced by the widely used drugs that act on these hormone/enzymes.
The combined training model applied proves to be an important tool for the treatment of type 2 diabetes even with a relatively low weekly frequency (3 times a week).</description><identifier>ISSN: 1746-1391</identifier><identifier>ISSN: 1536-7290</identifier><identifier>EISSN: 1536-7290</identifier><identifier>DOI: 10.1002/ejsc.12057</identifier><identifier>PMID: 39661009</identifier><language>eng</language><publisher>Germany: John Wiley & Sons, Inc</publisher><subject>Abstinence ; amylin/islet amyloid polypeptide (IAPP) ; Blood Glucose - metabolism ; Blood pressure ; Body composition ; Body Mass Index ; Cardiovascular disease ; Clinical trials ; combined training ; Diabetes ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes Mellitus, Type 2 - therapy ; dipeptidyl peptidase‐4 (DPP‐4) ; Enzymes ; Exercise ; Female ; Gastric Inhibitory Polypeptide - blood ; Glucagon ; Glucagon-Like Peptide 1 - blood ; Glucagon-Like Peptide 1 - metabolism ; glucagon‐like peptide‐1 (GLP‐1) ; Glucose ; glucose‐dependent insulinotropic polypeptide (GIP) ; Heart rate ; Hormones ; Humans ; Incretins - blood ; Insulin resistance ; insulin‐degrading enzyme (IDE) ; Islet Amyloid Polypeptide - blood ; Lipoproteins ; Male ; Metabolism ; Middle Aged ; Overweight ; Overweight - metabolism ; Overweight - therapy ; Physical fitness ; Physiology ; Polypeptides ; Resistance Training</subject><ispartof>European journal of sport science, 2024-01, Vol.24 (1), p.97-106</ispartof><rights>2024 The Authors. European Journal of Sport Science published by Wiley‐VCH GmbH on behalf of European College of Sport Science.</rights><rights>2024. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0/ (the "License"). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c3527-a9dafa51be5b2caea554dfa1b53f3f5c350290b0d464affae96e226dd28036213</cites><orcidid>0000-0001-6278-4611</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fejsc.12057$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fejsc.12057$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,11542,27903,27904,46030,46454</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39661009$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bonfante, Ivan Luiz Padilha</creatorcontrib><creatorcontrib>Duft, Renata Garbellini</creatorcontrib><creatorcontrib>Mateus, Keryma Chaves da Silva</creatorcontrib><creatorcontrib>Trombeta, Joice Cristina dos Santos</creatorcontrib><creatorcontrib>Chacon‐Mikahil, Mara Patricia Traina</creatorcontrib><creatorcontrib>Velloso, Licio Augusto</creatorcontrib><creatorcontrib>Cavaglieri, Cláudia Regina</creatorcontrib><title>Combined training and hormones/enzymes with insulinotropic actions in individuals with overweight and type 2 diabetes mellitus: A randomized controlled trial</title><title>European journal of sport science</title><addtitle>Eur J Sport Sci</addtitle><description>The incretins (glucose‐dependent insulinotropic polypeptide [GIP] and glucagon‐like peptide‐1 [GLP‐1]), along with amylin/islet amyloid polypeptide (IAPP) and insulin‐degrading enzyme (IDE), are hormones/enzymes that have been pharmacological targets, such as dipeptidyl peptidase‐4 (DPP‐4) inhibitors, due to their insulinotropic actions. Physical training is recommended as a treatment for type 2 diabetes mellitus (T2DM); however, its effects on the concentrations of these hormones/enzymes are not well known. Thus, the present study aimed to evaluate the effects of combined training (CT) on the concentrations of hormones/enzymes with insulinotropic actions in individuals with T2DM and overweight. Individuals of both sexes with T2DM (age 51.73 ± 4.19 years; body mass index [BMI] 29.46 ± 3.39 kg/m2) were randomly distributed in the control group (CG, n = 17) and the combined training group (CTG, n = 17). The CT consisted of strength followed by erobic training, 3 times/week, for 16 weeks. Functional variables, body composition, and serum biochemical analyses (clinical markers, GLP‐1, GIP, DPP‐4, amylin/IAPP, and IDE) were evaluated. The CTG showed a decrease in GLP‐1 (pre: 32.8 ± 12.1, post: 28.4 ± 13.5, and p = 0.04) in the group/time analysis. In the evaluation of the Δ% of variation, CTG presented a decrease for GLP‐1 (−9.3%; p = 0.03) and amylin/IAPP (−13.4%; p < 0.01), in addition to an increase for DPP‐4 (6.2%; p = 0.04) enzyme. CT decreases the baseline levels of important hormones with insulinotropic actions in individuals with T2DM and overweight. The improvement in overall metabolism provided by CT must be the main reason for these effects. These results broaden the understanding of the effects and relationships between CT and glucose metabolism.
Highlights
In addition to the well‐known effects of exercise training on glycemic control, trained type 2 diabetes patients can obtain positive effects on other hormones and enzymes with insulinotropic actions.
Global metabolic benefits provided by combined training induce different effects on GLP1 and DPP4 those induced by the widely used drugs that act on these hormone/enzymes.
The combined training model applied proves to be an important tool for the treatment of type 2 diabetes even with a relatively low weekly frequency (3 times a week).</description><subject>Abstinence</subject><subject>amylin/islet amyloid polypeptide (IAPP)</subject><subject>Blood Glucose - metabolism</subject><subject>Blood pressure</subject><subject>Body composition</subject><subject>Body Mass Index</subject><subject>Cardiovascular disease</subject><subject>Clinical trials</subject><subject>combined training</subject><subject>Diabetes</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - metabolism</subject><subject>Diabetes Mellitus, Type 2 - therapy</subject><subject>dipeptidyl peptidase‐4 (DPP‐4)</subject><subject>Enzymes</subject><subject>Exercise</subject><subject>Female</subject><subject>Gastric Inhibitory Polypeptide - blood</subject><subject>Glucagon</subject><subject>Glucagon-Like Peptide 1 - blood</subject><subject>Glucagon-Like Peptide 1 - metabolism</subject><subject>glucagon‐like peptide‐1 (GLP‐1)</subject><subject>Glucose</subject><subject>glucose‐dependent insulinotropic polypeptide (GIP)</subject><subject>Heart rate</subject><subject>Hormones</subject><subject>Humans</subject><subject>Incretins - blood</subject><subject>Insulin resistance</subject><subject>insulin‐degrading enzyme (IDE)</subject><subject>Islet Amyloid Polypeptide - blood</subject><subject>Lipoproteins</subject><subject>Male</subject><subject>Metabolism</subject><subject>Middle Aged</subject><subject>Overweight</subject><subject>Overweight - metabolism</subject><subject>Overweight - therapy</subject><subject>Physical fitness</subject><subject>Physiology</subject><subject>Polypeptides</subject><subject>Resistance Training</subject><issn>1746-1391</issn><issn>1536-7290</issn><issn>1536-7290</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNp9kctqGzEUhkVpaS7tpg9QBN2EwiS6jGSru2DStCWQRdu10IzOxMfMSK40E-O8S981iu12kUVAIHH49PFzfkI-cHbOGRMXsMrtORdMzV6RY66krmbCsNflPat1xaXhR-Qk5xVjZSDmb8mRNFqXr-aY_F3EocEAno7JYcBwR13wdBnTEAPkCwgP2wEy3eC4pBjy1GOIY4prbKlrR4whl3E5Hu_RT64_oPEe0gbwbjnufON2DVRQj66BsegG6Hscp_yFXtJUgDjgQ8nQxlDcfb-Lg65_R950RQnvD_cp-f316tfiW3Vze_19cXlTtVKJWeWMd51TvAHViNaBU6r2neONkp3sVIFYWUjDfK1r13UOjAYhtPdizqQWXJ6Ss713neKfCfJoB8xtyegCxClbyWuthdHGFPTTM3QVpxRKOiuZYWrOjdGF-ryn2hRzTtDZdcLBpa3lzD6VZp9Ks7vSCvzxoJyaAfx_9F9LBeB7YIM9bF9Q2asfPxd76SOJiKXg</recordid><startdate>202401</startdate><enddate>202401</enddate><creator>Bonfante, Ivan Luiz Padilha</creator><creator>Duft, Renata Garbellini</creator><creator>Mateus, Keryma Chaves da Silva</creator><creator>Trombeta, Joice Cristina dos Santos</creator><creator>Chacon‐Mikahil, Mara Patricia Traina</creator><creator>Velloso, Licio Augusto</creator><creator>Cavaglieri, Cláudia Regina</creator><general>John Wiley & Sons, Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6278-4611</orcidid></search><sort><creationdate>202401</creationdate><title>Combined training and hormones/enzymes with insulinotropic actions in individuals with overweight and type 2 diabetes mellitus: A randomized controlled trial</title><author>Bonfante, Ivan Luiz Padilha ; Duft, Renata Garbellini ; Mateus, Keryma Chaves da Silva ; Trombeta, Joice Cristina dos Santos ; Chacon‐Mikahil, Mara Patricia Traina ; Velloso, Licio Augusto ; Cavaglieri, Cláudia Regina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3527-a9dafa51be5b2caea554dfa1b53f3f5c350290b0d464affae96e226dd28036213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Abstinence</topic><topic>amylin/islet amyloid polypeptide (IAPP)</topic><topic>Blood Glucose - metabolism</topic><topic>Blood pressure</topic><topic>Body composition</topic><topic>Body Mass Index</topic><topic>Cardiovascular disease</topic><topic>Clinical trials</topic><topic>combined training</topic><topic>Diabetes</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - metabolism</topic><topic>Diabetes Mellitus, Type 2 - therapy</topic><topic>dipeptidyl peptidase‐4 (DPP‐4)</topic><topic>Enzymes</topic><topic>Exercise</topic><topic>Female</topic><topic>Gastric Inhibitory Polypeptide - blood</topic><topic>Glucagon</topic><topic>Glucagon-Like Peptide 1 - blood</topic><topic>Glucagon-Like Peptide 1 - metabolism</topic><topic>glucagon‐like peptide‐1 (GLP‐1)</topic><topic>Glucose</topic><topic>glucose‐dependent insulinotropic polypeptide (GIP)</topic><topic>Heart rate</topic><topic>Hormones</topic><topic>Humans</topic><topic>Incretins - blood</topic><topic>Insulin resistance</topic><topic>insulin‐degrading enzyme (IDE)</topic><topic>Islet Amyloid Polypeptide - blood</topic><topic>Lipoproteins</topic><topic>Male</topic><topic>Metabolism</topic><topic>Middle Aged</topic><topic>Overweight</topic><topic>Overweight - metabolism</topic><topic>Overweight - therapy</topic><topic>Physical fitness</topic><topic>Physiology</topic><topic>Polypeptides</topic><topic>Resistance Training</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bonfante, Ivan Luiz Padilha</creatorcontrib><creatorcontrib>Duft, Renata Garbellini</creatorcontrib><creatorcontrib>Mateus, Keryma Chaves da Silva</creatorcontrib><creatorcontrib>Trombeta, Joice Cristina dos Santos</creatorcontrib><creatorcontrib>Chacon‐Mikahil, Mara Patricia Traina</creatorcontrib><creatorcontrib>Velloso, Licio Augusto</creatorcontrib><creatorcontrib>Cavaglieri, Cláudia Regina</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Wiley Free Content</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of sport science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bonfante, Ivan Luiz Padilha</au><au>Duft, Renata Garbellini</au><au>Mateus, Keryma Chaves da Silva</au><au>Trombeta, Joice Cristina dos Santos</au><au>Chacon‐Mikahil, Mara Patricia Traina</au><au>Velloso, Licio Augusto</au><au>Cavaglieri, Cláudia Regina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Combined training and hormones/enzymes with insulinotropic actions in individuals with overweight and type 2 diabetes mellitus: A randomized controlled trial</atitle><jtitle>European journal of sport science</jtitle><addtitle>Eur J Sport Sci</addtitle><date>2024-01</date><risdate>2024</risdate><volume>24</volume><issue>1</issue><spage>97</spage><epage>106</epage><pages>97-106</pages><issn>1746-1391</issn><issn>1536-7290</issn><eissn>1536-7290</eissn><abstract>The incretins (glucose‐dependent insulinotropic polypeptide [GIP] and glucagon‐like peptide‐1 [GLP‐1]), along with amylin/islet amyloid polypeptide (IAPP) and insulin‐degrading enzyme (IDE), are hormones/enzymes that have been pharmacological targets, such as dipeptidyl peptidase‐4 (DPP‐4) inhibitors, due to their insulinotropic actions. Physical training is recommended as a treatment for type 2 diabetes mellitus (T2DM); however, its effects on the concentrations of these hormones/enzymes are not well known. Thus, the present study aimed to evaluate the effects of combined training (CT) on the concentrations of hormones/enzymes with insulinotropic actions in individuals with T2DM and overweight. Individuals of both sexes with T2DM (age 51.73 ± 4.19 years; body mass index [BMI] 29.46 ± 3.39 kg/m2) were randomly distributed in the control group (CG, n = 17) and the combined training group (CTG, n = 17). The CT consisted of strength followed by erobic training, 3 times/week, for 16 weeks. Functional variables, body composition, and serum biochemical analyses (clinical markers, GLP‐1, GIP, DPP‐4, amylin/IAPP, and IDE) were evaluated. The CTG showed a decrease in GLP‐1 (pre: 32.8 ± 12.1, post: 28.4 ± 13.5, and p = 0.04) in the group/time analysis. In the evaluation of the Δ% of variation, CTG presented a decrease for GLP‐1 (−9.3%; p = 0.03) and amylin/IAPP (−13.4%; p < 0.01), in addition to an increase for DPP‐4 (6.2%; p = 0.04) enzyme. CT decreases the baseline levels of important hormones with insulinotropic actions in individuals with T2DM and overweight. The improvement in overall metabolism provided by CT must be the main reason for these effects. These results broaden the understanding of the effects and relationships between CT and glucose metabolism.
Highlights
In addition to the well‐known effects of exercise training on glycemic control, trained type 2 diabetes patients can obtain positive effects on other hormones and enzymes with insulinotropic actions.
Global metabolic benefits provided by combined training induce different effects on GLP1 and DPP4 those induced by the widely used drugs that act on these hormone/enzymes.
The combined training model applied proves to be an important tool for the treatment of type 2 diabetes even with a relatively low weekly frequency (3 times a week).</abstract><cop>Germany</cop><pub>John Wiley & Sons, Inc</pub><pmid>39661009</pmid><doi>10.1002/ejsc.12057</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-6278-4611</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1746-1391 |
| ispartof | European journal of sport science, 2024-01, Vol.24 (1), p.97-106 |
| issn | 1746-1391 1536-7290 1536-7290 |
| language | eng |
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| subjects | Abstinence amylin/islet amyloid polypeptide (IAPP) Blood Glucose - metabolism Blood pressure Body composition Body Mass Index Cardiovascular disease Clinical trials combined training Diabetes Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - metabolism Diabetes Mellitus, Type 2 - therapy dipeptidyl peptidase‐4 (DPP‐4) Enzymes Exercise Female Gastric Inhibitory Polypeptide - blood Glucagon Glucagon-Like Peptide 1 - blood Glucagon-Like Peptide 1 - metabolism glucagon‐like peptide‐1 (GLP‐1) Glucose glucose‐dependent insulinotropic polypeptide (GIP) Heart rate Hormones Humans Incretins - blood Insulin resistance insulin‐degrading enzyme (IDE) Islet Amyloid Polypeptide - blood Lipoproteins Male Metabolism Middle Aged Overweight Overweight - metabolism Overweight - therapy Physical fitness Physiology Polypeptides Resistance Training |
| title | Combined training and hormones/enzymes with insulinotropic actions in individuals with overweight and type 2 diabetes mellitus: A randomized controlled trial |
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