Cation Enrichment Effect Modulated Nafion/Graphene Field-Effect Transistor for Ultrasensitive RNA Detection
The graphene field-effect transistor (GFET) biosensor serves as a foundational platform for detecting biomolecules, offering high conductivity, label-free operation, and easy integration. These features have garnered significant attention in biomarker detection. However, the presence of free cations...
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| Veröffentlicht in: | Nano letters 2024-12, Vol.24 (51), p.16245-16252 |
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| container_issue | 51 |
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| container_title | Nano letters |
| container_volume | 24 |
| creator | Ma, Heqi Chen, Shuo Zhang, Xinhao Sun, Tianyu Huo, Panpan Cui, Xiangyong Man, Baoyuan Yang, Cheng Wei, Dongmei |
| description | The graphene field-effect transistor (GFET) biosensor serves as a foundational platform for detecting biomolecules, offering high conductivity, label-free operation, and easy integration. These features have garnered significant attention in biomarker detection. However, the presence of free cations in solution often leads to electrostatic shielding of negatively charged biomolecules, reducing GFET detection sensitivity (LOD ≥ 1 fM). Additionally, the limited capacitance change in GFET restricts its use as a response signal. This study introduces a cation enrichment electric field modulation strategy (CEEFMS) to enhance capacitance and Dirac voltage response during detection. The cation-enriched rough Nafion/graphene FET (CENG-FET) achieves RNA detection at the aM level. Utilizing total capacitance change and Dirac voltage shift as response signals, the CENG-FET demonstrates a wide linear range from 1 aM to 1 pM. These findings advance dual-signal detection strategies, reducing accidental inaccuracies in biomolecular sensing and paving the way for further research. |
| doi_str_mv | 10.1021/acs.nanolett.4c03989 |
| format | Article |
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These features have garnered significant attention in biomarker detection. However, the presence of free cations in solution often leads to electrostatic shielding of negatively charged biomolecules, reducing GFET detection sensitivity (LOD ≥ 1 fM). Additionally, the limited capacitance change in GFET restricts its use as a response signal. This study introduces a cation enrichment electric field modulation strategy (CEEFMS) to enhance capacitance and Dirac voltage response during detection. The cation-enriched rough Nafion/graphene FET (CENG-FET) achieves RNA detection at the aM level. Utilizing total capacitance change and Dirac voltage shift as response signals, the CENG-FET demonstrates a wide linear range from 1 aM to 1 pM. 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These findings advance dual-signal detection strategies, reducing accidental inaccuracies in biomolecular sensing and paving the way for further research.</description><subject>Biosensing Techniques - instrumentation</subject><subject>Biosensing Techniques - methods</subject><subject>Cations - analysis</subject><subject>Fluorocarbon Polymers - chemistry</subject><subject>Graphite - chemistry</subject><subject>Limit of Detection</subject><subject>RNA - analysis</subject><subject>Transistors, Electronic</subject><issn>1530-6984</issn><issn>1530-6992</issn><issn>1530-6992</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kVFLwzAUhYMoOqf_QKSPvnRLkzRpHsecU9AJ4p5D2tywapfOJBX890a2-XC5l8PH4XIOQjcFnhSYFFPdhInTru8gxglrMJWVPEGjoqQ451KS0_-7YhfoMoQPjLGkJT5HF1RyjoUQI_Q517HtXbZwvm02W3AxW1gLTcxeejN0OoLJVtomZLr0ercBB9lDC53JD9i71y60IfY-s2nWXfQ6QJJi-w3Z22qW3UNMYHK4QmdWdwGuD3uM1g-L9_lj_vy6fJrPnnNdVCTmWtYclwyIbWqjKZWMWFkyUVlWC0FrybgRTY2ZIaauBcZGYl4VXFheltBwOkZ3e9-d778GCFFt29BA12kH_RAULRjnpJIVSejtAR3qLRi18-1W-x91DCgBeA-kuNVHP3iXPlcFVn8dqD_x2IE6dEB_AXD2e-s</recordid><startdate>20241225</startdate><enddate>20241225</enddate><creator>Ma, Heqi</creator><creator>Chen, Shuo</creator><creator>Zhang, Xinhao</creator><creator>Sun, Tianyu</creator><creator>Huo, Panpan</creator><creator>Cui, Xiangyong</creator><creator>Man, Baoyuan</creator><creator>Yang, Cheng</creator><creator>Wei, Dongmei</creator><general>American Chemical Society</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7428-1819</orcidid><orcidid>https://orcid.org/0009-0002-2657-4320</orcidid></search><sort><creationdate>20241225</creationdate><title>Cation Enrichment Effect Modulated Nafion/Graphene Field-Effect Transistor for Ultrasensitive RNA Detection</title><author>Ma, Heqi ; Chen, Shuo ; Zhang, Xinhao ; Sun, Tianyu ; Huo, Panpan ; Cui, Xiangyong ; Man, Baoyuan ; Yang, Cheng ; Wei, Dongmei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a182t-a9b6054e2fcbda33942f95478f4b773b946d7cb04d2dbb700d9068167f655ec63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Biosensing Techniques - instrumentation</topic><topic>Biosensing Techniques - methods</topic><topic>Cations - analysis</topic><topic>Fluorocarbon Polymers - chemistry</topic><topic>Graphite - chemistry</topic><topic>Limit of Detection</topic><topic>RNA - analysis</topic><topic>Transistors, Electronic</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ma, Heqi</creatorcontrib><creatorcontrib>Chen, Shuo</creatorcontrib><creatorcontrib>Zhang, Xinhao</creatorcontrib><creatorcontrib>Sun, Tianyu</creatorcontrib><creatorcontrib>Huo, Panpan</creatorcontrib><creatorcontrib>Cui, Xiangyong</creatorcontrib><creatorcontrib>Man, Baoyuan</creatorcontrib><creatorcontrib>Yang, Cheng</creatorcontrib><creatorcontrib>Wei, Dongmei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Nano letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ma, Heqi</au><au>Chen, Shuo</au><au>Zhang, Xinhao</au><au>Sun, Tianyu</au><au>Huo, Panpan</au><au>Cui, Xiangyong</au><au>Man, Baoyuan</au><au>Yang, Cheng</au><au>Wei, Dongmei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cation Enrichment Effect Modulated Nafion/Graphene Field-Effect Transistor for Ultrasensitive RNA Detection</atitle><jtitle>Nano letters</jtitle><addtitle>Nano Lett</addtitle><date>2024-12-25</date><risdate>2024</risdate><volume>24</volume><issue>51</issue><spage>16245</spage><epage>16252</epage><pages>16245-16252</pages><issn>1530-6984</issn><issn>1530-6992</issn><eissn>1530-6992</eissn><abstract>The graphene field-effect transistor (GFET) biosensor serves as a foundational platform for detecting biomolecules, offering high conductivity, label-free operation, and easy integration. These features have garnered significant attention in biomarker detection. However, the presence of free cations in solution often leads to electrostatic shielding of negatively charged biomolecules, reducing GFET detection sensitivity (LOD ≥ 1 fM). Additionally, the limited capacitance change in GFET restricts its use as a response signal. This study introduces a cation enrichment electric field modulation strategy (CEEFMS) to enhance capacitance and Dirac voltage response during detection. The cation-enriched rough Nafion/graphene FET (CENG-FET) achieves RNA detection at the aM level. Utilizing total capacitance change and Dirac voltage shift as response signals, the CENG-FET demonstrates a wide linear range from 1 aM to 1 pM. These findings advance dual-signal detection strategies, reducing accidental inaccuracies in biomolecular sensing and paving the way for further research.</abstract><cop>United States</cop><pub>American Chemical Society</pub><pmid>39660777</pmid><doi>10.1021/acs.nanolett.4c03989</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-7428-1819</orcidid><orcidid>https://orcid.org/0009-0002-2657-4320</orcidid></addata></record> |
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| source | MEDLINE; ACS Publications |
| subjects | Biosensing Techniques - instrumentation Biosensing Techniques - methods Cations - analysis Fluorocarbon Polymers - chemistry Graphite - chemistry Limit of Detection RNA - analysis Transistors, Electronic |
| title | Cation Enrichment Effect Modulated Nafion/Graphene Field-Effect Transistor for Ultrasensitive RNA Detection |
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