O-GlcNAcylation of progranulin promotes hepatocellular carcinoma proliferation

Progranulin (PGRN) is overexpressed and implicated in hepatocellular carcinoma (HCC) development; however, its post-translational modifications and regulatory mechanisms in HCC remain largely unexplored. Here, the expression levels of PGRN, OGT, and O-GlcNAcylation were found to be elevated in both...

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Veröffentlicht in:	Biochemical and biophysical research communications 2025-01, Vol.742, p.151150, Article 151150
Hauptverfasser:	Liang, Yi, Chen, Liqiong, Huang, Zhuanglin, Li, Yueliang, Weng, Hanqin, Guo, Lianxian
Format:	Artikel
Sprache:	eng
Schlagworte:	Acetylglucosamine - metabolism Carcinoma, Hepatocellular - metabolism Carcinoma, Hepatocellular - pathology Cell Line, Tumor Cell Proliferation Glycosylation Hepatocellular carcinoma Humans Liver Neoplasms - metabolism Liver Neoplasms - pathology N-Acetylglucosaminyltransferases - genetics N-Acetylglucosaminyltransferases - metabolism O-GlcNAcylation PGRN Phosphatidylinositol 3-Kinases - metabolism Progranulins - genetics Progranulins - metabolism Proliferation Protein Processing, Post-Translational Proto-Oncogene Proteins c-akt - metabolism Signal Transduction TOR Serine-Threonine Kinases - metabolism Ubiquitination
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