The detrimental effects and mechanisms of Orlistat in disrupting energy homeostasis and reproduction in Daphnia magna

•ORL exposure inhibited lipase activity in D. magna.•ORL exposure downregulated reproductive capacity in D. magna.•ORL exposure disturbed energy homeostasis in D. magna.•Mitochondrial dysfunction occurred in D. magna after chronic ORL exposure.•D. magna boosted their glycolysis to counter energy def...

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Veröffentlicht in:	Aquatic toxicology 2025-02, Vol.279, p.107201, Article 107201
Hauptverfasser:	Ni, Zhihua, Tian, Xinling, Zhao, Wenbo, Hu, Wenkai, Lv, Jinghua, Sun, Xiaoli, Zhang, Yajie, Zhang, Yiwen, Zhang, Yuming, Li, Baoku, Liu, Fengsong
Format:	Artikel
Sprache:	eng
Schlagworte:	absorption Daphnia magna digestive enzymes energy feces genotoxicity homeostasis Lipase metabolites Metabonomics mitochondria Mitochondrion Orlistat reproductive performance tricarboxylic acid cycle
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