Dual BACH1 regulation by complementary SCF-type E3 ligases

Broad-complex, tramtrack, and bric-à-brac domain (BTB) and CNC homolog 1 (BACH1) is a key regulator of the cellular oxidative stress response and an oncogene that undergoes tight post-translational control by two distinct F-box ubiquitin ligases, SCFFBXO22 and SCFFBXL17. However, how both ligases re...

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Veröffentlicht in:	Cell 2024-12, Vol.187 (26), p.7585-7602.e25
Hauptverfasser:	Goretzki, Benedikt, Khoshouei, Maryam, Schröder, Martin, Penner, Patrick, Egger, Luca, Stephan, Christine, Argoti, Dayana, Dierlamm, Nele, Rada, Jimena Maria, Kapps, Sandra, Müller, Catrin Swantje, Thiel, Zacharias, Mutlu, Merve, Tschopp, Claude, Furkert, David, Freuler, Felix, Haenni, Simon, Tenaillon, Laurent, Knapp, Britta, Hinniger, Alexandra, Hoppe, Philipp, Schmidt, Enrico, Gutmann, Sascha, Iurlaro, Mario, Ryzhakov, Grigory, Fernández, César
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals BACH1 Basic-Leucine Zipper Transcription Factors - genetics Basic-Leucine Zipper Transcription Factors - metabolism Cullin-RING ligases cysteine modification F-box F-Box Proteins - chemistry F-Box Proteins - metabolism FBXL17 FBXO22 HEK293 Cells Humans ligase switch Models, Molecular Oxidative Stress S-nitrosylation heme SKP Cullin F-Box Protein Ligases - metabolism Ubiquitin-Protein Ligases - chemistry Ubiquitin-Protein Ligases - metabolism
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