Metabolic engineering improves transduction efficiency and downstream vector isolation by altering the lipid composition of extracellular vesicle-enclosed AAV

Adeno-associated viruses (AAV) are promising vectors for gene therapy due to their efficacy in vivo. However, there is room for improvement to address key limitations such as the pre-existing immunity to AAV in patients, high-dose toxicity, and relatively low efficiency for some cell types. This stu...

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Veröffentlicht in:	Metabolic engineering 2025-03, Vol.88, p.40-49
Hauptverfasser:	Espinoza, Paula, Cheng, Ming, Ng, Carrie, Cruz, Demitri de la, Wasson, Elizabeth D., McCarthy, Deirdre M., Bhide, Pradeep G., Maguire, Casey A., Santoscoy, Miguel C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Downstream EV-AAV Membrane engineering Upstream
Online-Zugang:	Volltext
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