Nanomolar activity of coumarin-3-thiosemicarbazones targeting Trypanosoma cruzi cruzain and the T. brucei cathepsin L-like protease

Trypanosoma cruzi (T. cruzi) and Trypanosoma brucei (T. brucei) urgently demand innovative drug development due to their impact on public health worldwide. Their cysteine proteases, Cruzain (CRZ) and the T. brucei Cathepsin L-like protease (TbrCATL) are established drug targets for these parasites....

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of medicinal chemistry 2025-02, Vol.283, p.117109, Article 117109
Hauptverfasser:	Nunes, Jéssica Alves, Santos-Júnior, Paulo Fernando da Silva, Gomes, Midiane Correa, Ferreira, Luiz Alberto Santos, Padilha, Emanuelly Karla Araújo, Teixeira, Thaiz Rodrigues, Stanger, Emily J., Kaur, Yashpreet, Silva, Elany Barbosa da, Costa, Clara Andrezza Crisóstomo Bezerra, Freitas, Johnnatan Duarte de, Araújo-Júnior, João Xavier de, Mendonça-Junior, Francisco Jaime Bezerra, Giardini, Miriam A., Siqueira-Neto, Jair L., Caffrey, Conor R., Zhan, Peng, Cardoso, Sílvia Helena, Silva-Júnior, Edeildo Ferreira da
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carboxamides Cathepsin L - antagonists & inhibitors Cathepsin L - metabolism Coumarines Coumarins - chemical synthesis Coumarins - chemistry Coumarins - pharmacology Cysteine Endopeptidases - metabolism Cysteine Proteinase Inhibitors - chemical synthesis Cysteine Proteinase Inhibitors - chemistry Cysteine Proteinase Inhibitors - metabolism Cysteine Proteinase Inhibitors - pharmacology Dose-Response Relationship, Drug Humans Molecular Dynamics Simulation Molecular Structure Multiscale QM/QM calculations Parasitic Sensitivity Tests Protozoan Proteins - antagonists & inhibitors Protozoan Proteins - metabolism Structure-Activity Relationship Thiosemicarbazones Thiosemicarbazones - chemistry Thiosemicarbazones - pharmacology Trypanocidal Agents - chemical synthesis Trypanocidal Agents - chemistry Trypanocidal Agents - pharmacology Trypanosoma Trypanosoma brucei brucei - drug effects Trypanosoma brucei brucei - enzymology Trypanosoma cruzi - drug effects Trypanosoma cruzi - enzymology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!