An Alkyne-Containing Isoprenoid Analogue Based on a Farnesyl Diphosphate Scaffold Is a Biologically Functional Universal Probe for Proteomic Analysis

Prenylation consists of the modification of proteins with either farnesyl diphosphate (FPP) or geranylgeranyl diphosphate (GGPP) at a cysteine near the C-terminus of target proteins to generate thioether-linked lipidated proteins. In recent work, metabolic labeling with alkyne-containing isoprenoid...

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Veröffentlicht in:	Biochemistry (Easton) 2025-01, Vol.64 (1), p.138-155
Hauptverfasser:	Auger, Shelby A., Pedersen, Jodi S., Maity, Sanjay, Sprague-Getsy, Andrea M., Lorimer, Ellen L., Koehn, Olivia J., Krauklis, Steven A., Berns, Brenna, Murphy, Katherine M., Hussain, Jamal, Thao, Pa, Bernhagen, Kaitlyn, Justyna, Katarzyna, Sundaresan, Anjana P., McKim, Daniel B., Williams, Carol L., Hougland, James L., Li, Ling, Distefano, Mark D.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkynes - chemistry Alkynes - metabolism Animals Humans Mice Molecular Probes - chemistry Molecular Probes - metabolism Polyisoprenyl Phosphates - chemistry Polyisoprenyl Phosphates - metabolism Protein Prenylation Proteomics - methods RAW 264.7 Cells Sesquiterpenes - chemistry Sesquiterpenes - metabolism Terpenes - chemistry Terpenes - metabolism
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