Printable and Tunable Bioresin with Strategically Decorated Molecular Structures
As personalized medicine rapidly evolves, there is a critical demand for advanced biocompatible materials surpassing current additive manufacturing capabilities. This study presents a novel printable bioresin engineered with tunable mechanical, thermal, and biocompatibility properties through strate...
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| Veröffentlicht in: | Advanced materials (Weinheim) 2025-01, Vol.37 (4), p.e2412338 |
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| container_title | Advanced materials (Weinheim) |
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| creator | Rufo-Martín, Celia Infante-García, Diego Díaz-Álvarez, José Miguélez, Henar Youssef, George |
| description | As personalized medicine rapidly evolves, there is a critical demand for advanced biocompatible materials surpassing current additive manufacturing capabilities. This study presents a novel printable bioresin engineered with tunable mechanical, thermal, and biocompatibility properties through strategic molecular modifications. The study introduces a new bioresin comprising methyl methacrylate (MMA), ethylene glycol dimethacrylate (EGDMA), and a photoinitiator, which is further enhanced by incorporating high molecular weight polymethyl methacrylate (PMMA) to improve biostability and mechanical performance. The integration of printable PMMA presents several synthesis and processing challenges, necessitating substantial modifications to the 3D printing process. Additionally, the bioresin is functionalized with antibacterial silver oxide and bone-growth-promoting hydroxyapatite at various weight ratios to extend its application further. The results demonstrate the agile printability of the novel bioresin and its potential for transformative impact in biomedical applications, offering a versatile material platform for additive manufacturing-enabled personalized medicine. This work highlights the adaptability of the novel printable bioresin for real-life applications and its capacity for multiscale structural tailoring, potentially achieving properties comparable to native tissues and extending beyond conventional additive manufacturing techniques. |
| doi_str_mv | 10.1002/adma.202412338 |
| format | Article |
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This study presents a novel printable bioresin engineered with tunable mechanical, thermal, and biocompatibility properties through strategic molecular modifications. The study introduces a new bioresin comprising methyl methacrylate (MMA), ethylene glycol dimethacrylate (EGDMA), and a photoinitiator, which is further enhanced by incorporating high molecular weight polymethyl methacrylate (PMMA) to improve biostability and mechanical performance. The integration of printable PMMA presents several synthesis and processing challenges, necessitating substantial modifications to the 3D printing process. Additionally, the bioresin is functionalized with antibacterial silver oxide and bone-growth-promoting hydroxyapatite at various weight ratios to extend its application further. The results demonstrate the agile printability of the novel bioresin and its potential for transformative impact in biomedical applications, offering a versatile material platform for additive manufacturing-enabled personalized medicine. This work highlights the adaptability of the novel printable bioresin for real-life applications and its capacity for multiscale structural tailoring, potentially achieving properties comparable to native tissues and extending beyond conventional additive manufacturing techniques.</description><identifier>ISSN: 0935-9648</identifier><identifier>ISSN: 1521-4095</identifier><identifier>EISSN: 1521-4095</identifier><identifier>DOI: 10.1002/adma.202412338</identifier><identifier>PMID: 39648663</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Additive manufacturing ; Agile manufacturing ; Anti-Bacterial Agents - chemistry ; Anti-Bacterial Agents - pharmacology ; Biocompatibility ; Biocompatible Materials - chemistry ; Biomedical materials ; Chemical synthesis ; Customization ; Durapatite - chemistry ; Ethylene glycol ; Glycol dimethacrylates ; Humans ; Hydroxyapatite ; Materials Testing ; Mechanical properties ; Methacrylates - chemistry ; Molecular structure ; Photoinitiators ; Polymethyl methacrylate ; Polymethyl Methacrylate - chemistry ; Precision medicine ; Printing, Three-Dimensional ; Silver oxides ; Three dimensional printing</subject><ispartof>Advanced materials (Weinheim), 2025-01, Vol.37 (4), p.e2412338</ispartof><rights>2024 Wiley‐VCH GmbH.</rights><rights>2025 Wiley‐VCH GmbH</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c208t-9ea08e659b9017d1dbeb89adf43fb19a94d304d6a7b27d200a2e6b3d9dbc16c03</cites><orcidid>0000-0003-2029-7692</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39648663$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rufo-Martín, Celia</creatorcontrib><creatorcontrib>Infante-García, Diego</creatorcontrib><creatorcontrib>Díaz-Álvarez, José</creatorcontrib><creatorcontrib>Miguélez, Henar</creatorcontrib><creatorcontrib>Youssef, George</creatorcontrib><title>Printable and Tunable Bioresin with Strategically Decorated Molecular Structures</title><title>Advanced materials (Weinheim)</title><addtitle>Adv Mater</addtitle><description>As personalized medicine rapidly evolves, there is a critical demand for advanced biocompatible materials surpassing current additive manufacturing capabilities. This study presents a novel printable bioresin engineered with tunable mechanical, thermal, and biocompatibility properties through strategic molecular modifications. The study introduces a new bioresin comprising methyl methacrylate (MMA), ethylene glycol dimethacrylate (EGDMA), and a photoinitiator, which is further enhanced by incorporating high molecular weight polymethyl methacrylate (PMMA) to improve biostability and mechanical performance. The integration of printable PMMA presents several synthesis and processing challenges, necessitating substantial modifications to the 3D printing process. Additionally, the bioresin is functionalized with antibacterial silver oxide and bone-growth-promoting hydroxyapatite at various weight ratios to extend its application further. The results demonstrate the agile printability of the novel bioresin and its potential for transformative impact in biomedical applications, offering a versatile material platform for additive manufacturing-enabled personalized medicine. This work highlights the adaptability of the novel printable bioresin for real-life applications and its capacity for multiscale structural tailoring, potentially achieving properties comparable to native tissues and extending beyond conventional additive manufacturing techniques.</description><subject>Additive manufacturing</subject><subject>Agile manufacturing</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Anti-Bacterial Agents - pharmacology</subject><subject>Biocompatibility</subject><subject>Biocompatible Materials - chemistry</subject><subject>Biomedical materials</subject><subject>Chemical synthesis</subject><subject>Customization</subject><subject>Durapatite - chemistry</subject><subject>Ethylene glycol</subject><subject>Glycol dimethacrylates</subject><subject>Humans</subject><subject>Hydroxyapatite</subject><subject>Materials Testing</subject><subject>Mechanical properties</subject><subject>Methacrylates - chemistry</subject><subject>Molecular structure</subject><subject>Photoinitiators</subject><subject>Polymethyl methacrylate</subject><subject>Polymethyl Methacrylate - chemistry</subject><subject>Precision medicine</subject><subject>Printing, Three-Dimensional</subject><subject>Silver oxides</subject><subject>Three dimensional printing</subject><issn>0935-9648</issn><issn>1521-4095</issn><issn>1521-4095</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkDtPwzAURi0EoqWwMqJILCwp13bixCOUp1REJcoc-RVI5STFjoX670lo6cB0Hzr309VB6BzDFAOQa6FrMSVAEkwozQ_QGKcExwnw9BCNgdM05izJR-jE-xUAcAbsGI3osGSMjtFi4aqmE9KaSDQ6Wobmt7-tWmd81UTfVfcZvXVOdOajUsLaTXRnVDvMOnpprVHBCjcQQXWhvzlFR6Ww3pzt6gS9P9wvZ0_x_PXxeXYzjxWBvIu5EZAblnLJAWcaa2lkzoUuE1pKzAVPNIVEM5FJkmkCIIhhkmqupcJMAZ2gq23u2rVfwfiuqCuvjLWiMW3wBcUJS3NKkrxHL_-hqza4pv-upxhkBBgZAqdbSrnWe2fKYu2qWrhNgaEYXBeD62Lvuj-42MUGWRu9x__k0h8m4nqC</recordid><startdate>202501</startdate><enddate>202501</enddate><creator>Rufo-Martín, Celia</creator><creator>Infante-García, Diego</creator><creator>Díaz-Álvarez, José</creator><creator>Miguélez, Henar</creator><creator>Youssef, George</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2029-7692</orcidid></search><sort><creationdate>202501</creationdate><title>Printable and Tunable Bioresin with Strategically Decorated Molecular Structures</title><author>Rufo-Martín, Celia ; Infante-García, Diego ; Díaz-Álvarez, José ; Miguélez, Henar ; Youssef, George</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c208t-9ea08e659b9017d1dbeb89adf43fb19a94d304d6a7b27d200a2e6b3d9dbc16c03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Additive manufacturing</topic><topic>Agile manufacturing</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Anti-Bacterial Agents - pharmacology</topic><topic>Biocompatibility</topic><topic>Biocompatible Materials - chemistry</topic><topic>Biomedical materials</topic><topic>Chemical synthesis</topic><topic>Customization</topic><topic>Durapatite - chemistry</topic><topic>Ethylene glycol</topic><topic>Glycol dimethacrylates</topic><topic>Humans</topic><topic>Hydroxyapatite</topic><topic>Materials Testing</topic><topic>Mechanical properties</topic><topic>Methacrylates - chemistry</topic><topic>Molecular structure</topic><topic>Photoinitiators</topic><topic>Polymethyl methacrylate</topic><topic>Polymethyl Methacrylate - chemistry</topic><topic>Precision medicine</topic><topic>Printing, Three-Dimensional</topic><topic>Silver oxides</topic><topic>Three dimensional printing</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rufo-Martín, Celia</creatorcontrib><creatorcontrib>Infante-García, Diego</creatorcontrib><creatorcontrib>Díaz-Álvarez, José</creatorcontrib><creatorcontrib>Miguélez, Henar</creatorcontrib><creatorcontrib>Youssef, George</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Advanced materials (Weinheim)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rufo-Martín, Celia</au><au>Infante-García, Diego</au><au>Díaz-Álvarez, José</au><au>Miguélez, Henar</au><au>Youssef, George</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Printable and Tunable Bioresin with Strategically Decorated Molecular Structures</atitle><jtitle>Advanced materials (Weinheim)</jtitle><addtitle>Adv Mater</addtitle><date>2025-01</date><risdate>2025</risdate><volume>37</volume><issue>4</issue><spage>e2412338</spage><pages>e2412338-</pages><issn>0935-9648</issn><issn>1521-4095</issn><eissn>1521-4095</eissn><abstract>As personalized medicine rapidly evolves, there is a critical demand for advanced biocompatible materials surpassing current additive manufacturing capabilities. This study presents a novel printable bioresin engineered with tunable mechanical, thermal, and biocompatibility properties through strategic molecular modifications. The study introduces a new bioresin comprising methyl methacrylate (MMA), ethylene glycol dimethacrylate (EGDMA), and a photoinitiator, which is further enhanced by incorporating high molecular weight polymethyl methacrylate (PMMA) to improve biostability and mechanical performance. The integration of printable PMMA presents several synthesis and processing challenges, necessitating substantial modifications to the 3D printing process. Additionally, the bioresin is functionalized with antibacterial silver oxide and bone-growth-promoting hydroxyapatite at various weight ratios to extend its application further. The results demonstrate the agile printability of the novel bioresin and its potential for transformative impact in biomedical applications, offering a versatile material platform for additive manufacturing-enabled personalized medicine. This work highlights the adaptability of the novel printable bioresin for real-life applications and its capacity for multiscale structural tailoring, potentially achieving properties comparable to native tissues and extending beyond conventional additive manufacturing techniques.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>39648663</pmid><doi>10.1002/adma.202412338</doi><orcidid>https://orcid.org/0000-0003-2029-7692</orcidid></addata></record> |
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| subjects | Additive manufacturing Agile manufacturing Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Biocompatibility Biocompatible Materials - chemistry Biomedical materials Chemical synthesis Customization Durapatite - chemistry Ethylene glycol Glycol dimethacrylates Humans Hydroxyapatite Materials Testing Mechanical properties Methacrylates - chemistry Molecular structure Photoinitiators Polymethyl methacrylate Polymethyl Methacrylate - chemistry Precision medicine Printing, Three-Dimensional Silver oxides Three dimensional printing |
| title | Printable and Tunable Bioresin with Strategically Decorated Molecular Structures |
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