A versatile approach for geometry-based self-assembly of DNA-protein hybrid nanostructures using histone-DNA interactions

A versatile approach for geometry-based self-assembly of DNA-protein hybrid nanostructures using histone-DNA interactions

We report an enhanced versatility in constructing DNA-protein hybrid nanostructures using histone-DNA complexes (HDs). By leveraging HDs, we demonstrate precise and scalable assembly of DNA origami tiles and a 2D triangular nanostructure. Our results extend the potential applications of DNA nanotech...

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Veröffentlicht in:Chemical communications (Cambridge, England) England), 2025-01, Vol.61 (3), p.532-535
Hauptverfasser: Al-Zarah, Hajar, Serag, Maged F, Alkhaldi, Faisal, Habuchi, Satoshi
Format: Artikel
Sprache:eng
Schlagworte:
DNA - chemistry
Histones
Histones - chemistry
Histones - metabolism
Nanostructure
Nanostructures - chemistry
Nanotechnology
Nucleic Acid Conformation
Proteins
Self-assembly
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Beschreibung
Zusammenfassung:We report an enhanced versatility in constructing DNA-protein hybrid nanostructures using histone-DNA complexes (HDs). By leveraging HDs, we demonstrate precise and scalable assembly of DNA origami tiles and a 2D triangular nanostructure. Our results extend the potential applications of DNA nanotechnology from the nanoscale to the microscale without the need for complex pre-designs.
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d4cc05253f