Clinical Insights and Outcomes in Community-Acquired Acute Bacterial Meningitis versus Postoperative Bacterial Meningitis
To compare the demographics, clinical characteristics, and in-hospital mortality rates between community-acquired bacterial meningitis cases and postoperative bacterial meningitis. Analytical study. Place and Duration of the Study: Department of Infectious Diseases and Clinical Microbiology, Diskapi...
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| Veröffentlicht in: | Journal of the College of Physicians and Surgeons--Pakistan 2024-12, Vol.34 (12), p.1441-1447 |
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| container_title | Journal of the College of Physicians and Surgeons--Pakistan |
| container_volume | 34 |
| creator | Parlayan, Hanife Nur Karakoc Solay, Asli Haykir Aksoy, Begum Ruveyda Bulut, Dilek Hojabri, Mahsa Sencan, Irfan |
| description | To compare the demographics, clinical characteristics, and in-hospital mortality rates between community-acquired bacterial meningitis cases and postoperative bacterial meningitis.
Analytical study. Place and Duration of the Study: Department of Infectious Diseases and Clinical Microbiology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkiye, from 2016 to 2022.
A total of 153 patients diagnosed with bacterial meningitis were included and categorised into two groups: 95 (62.1%) with community-acquired bacterial meningitis (CABM) and 58 (37.9%) with postoperative bacterial meningitis (POBM). Demographics, clinical features, laboratory, paraclinical findings, treatments, and outcomes of the cases were compared. Data were retrieved using a standard data collection form from the electronic medical records.
A substantial portion (58.8%) of all patients had comorbidities. Fever was the common symptom in all groups. Headache, neck stiffness, nausea, and vomiting were more often observed in the CABM group (p |
| doi_str_mv | 10.29271/jcpsp.2024.12.1441 |
| format | Article |
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Analytical study. Place and Duration of the Study: Department of Infectious Diseases and Clinical Microbiology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkiye, from 2016 to 2022.
A total of 153 patients diagnosed with bacterial meningitis were included and categorised into two groups: 95 (62.1%) with community-acquired bacterial meningitis (CABM) and 58 (37.9%) with postoperative bacterial meningitis (POBM). Demographics, clinical features, laboratory, paraclinical findings, treatments, and outcomes of the cases were compared. Data were retrieved using a standard data collection form from the electronic medical records.
A substantial portion (58.8%) of all patients had comorbidities. Fever was the common symptom in all groups. Headache, neck stiffness, nausea, and vomiting were more often observed in the CABM group (p <0.001). Upon admission, the CABM exhibited higher levels of white blood cell count, C-reactive protein, and procalcitonin (p = 0.017, p = 0.004, p = 0.007, respectively). Overall 33.1% had positive cerebrospinal fluid cultures. The overall mortality rate was 26.8%. POBM was associated with longer hospital and intensive care unit (ICU) stays (p <0.001). Shorter treatment durations, lower Glasgow coma scale scores (GCS), higher Charlson Comorbidity Index values, and elevated markers of inflammation were related to mortality.
This study illuminates the differences in clinical presentations and outcomes between community-acquired and postoperative bacterial meningitis. It also suggests that factors such as lower GCS scores, comorbidities, and elevated inflammation markers at the last follow-up may be associated with unfavourable clinical outcomes in bacterial meningitis.
Postoperative meningitis, Central nervous system infection, Cerebrospinal fluid, Antibiotics.</description><identifier>ISSN: 1022-386X</identifier><identifier>ISSN: 1681-7168</identifier><identifier>EISSN: 1681-7168</identifier><identifier>DOI: 10.29271/jcpsp.2024.12.1441</identifier><identifier>PMID: 39648377</identifier><language>eng</language><publisher>Pakistan</publisher><subject>Adult ; Aged ; Anti-Bacterial Agents - therapeutic use ; Community-Acquired Infections - mortality ; Female ; Hospital Mortality ; Humans ; Male ; Meningitis, Bacterial - cerebrospinal fluid ; Meningitis, Bacterial - epidemiology ; Meningitis, Bacterial - mortality ; Middle Aged ; Postoperative Complications - epidemiology</subject><ispartof>Journal of the College of Physicians and Surgeons--Pakistan, 2024-12, Vol.34 (12), p.1441-1447</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,777,781,27905,27906</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39648377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Parlayan, Hanife Nur Karakoc</creatorcontrib><creatorcontrib>Solay, Asli Haykir</creatorcontrib><creatorcontrib>Aksoy, Begum Ruveyda</creatorcontrib><creatorcontrib>Bulut, Dilek</creatorcontrib><creatorcontrib>Hojabri, Mahsa</creatorcontrib><creatorcontrib>Sencan, Irfan</creatorcontrib><title>Clinical Insights and Outcomes in Community-Acquired Acute Bacterial Meningitis versus Postoperative Bacterial Meningitis</title><title>Journal of the College of Physicians and Surgeons--Pakistan</title><addtitle>J Coll Physicians Surg Pak</addtitle><description>To compare the demographics, clinical characteristics, and in-hospital mortality rates between community-acquired bacterial meningitis cases and postoperative bacterial meningitis.
Analytical study. Place and Duration of the Study: Department of Infectious Diseases and Clinical Microbiology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkiye, from 2016 to 2022.
A total of 153 patients diagnosed with bacterial meningitis were included and categorised into two groups: 95 (62.1%) with community-acquired bacterial meningitis (CABM) and 58 (37.9%) with postoperative bacterial meningitis (POBM). Demographics, clinical features, laboratory, paraclinical findings, treatments, and outcomes of the cases were compared. Data were retrieved using a standard data collection form from the electronic medical records.
A substantial portion (58.8%) of all patients had comorbidities. Fever was the common symptom in all groups. Headache, neck stiffness, nausea, and vomiting were more often observed in the CABM group (p <0.001). Upon admission, the CABM exhibited higher levels of white blood cell count, C-reactive protein, and procalcitonin (p = 0.017, p = 0.004, p = 0.007, respectively). Overall 33.1% had positive cerebrospinal fluid cultures. The overall mortality rate was 26.8%. POBM was associated with longer hospital and intensive care unit (ICU) stays (p <0.001). Shorter treatment durations, lower Glasgow coma scale scores (GCS), higher Charlson Comorbidity Index values, and elevated markers of inflammation were related to mortality.
This study illuminates the differences in clinical presentations and outcomes between community-acquired and postoperative bacterial meningitis. It also suggests that factors such as lower GCS scores, comorbidities, and elevated inflammation markers at the last follow-up may be associated with unfavourable clinical outcomes in bacterial meningitis.
Postoperative meningitis, Central nervous system infection, Cerebrospinal fluid, Antibiotics.</description><subject>Adult</subject><subject>Aged</subject><subject>Anti-Bacterial Agents - therapeutic use</subject><subject>Community-Acquired Infections - mortality</subject><subject>Female</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Male</subject><subject>Meningitis, Bacterial - cerebrospinal fluid</subject><subject>Meningitis, Bacterial - epidemiology</subject><subject>Meningitis, Bacterial - mortality</subject><subject>Middle Aged</subject><subject>Postoperative Complications - epidemiology</subject><issn>1022-386X</issn><issn>1681-7168</issn><issn>1681-7168</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNptkMtKQzEQhoMoXqpPIEiWbk7NJGlOzrIWb6DoQsFdSJOpRs7NJKfQt7etl5Wb-Wfx_TPwEXIKbMwrXsLFh-tTP-aMyzHwMUgJO-QQlIaiXM_d9c44L4RWrwfkKKUPxsQEtN4nB6JSUouyPCSrWR3a4GxN79oU3t5zorb19HHIrmsw0dDSWdc0Qxvyqpi6zyFE9HTqhoz00rqMMay7D9iG9i3kkOgSYxoSfepS7nqMNofl_-Qx2VvYOuHJT47Iy_XV8-y2uH-8uZtN7wsHcgKFZehwAUqCt1YxVzLFSil1NQcv_KJUc47S6kqLiVXae22l8IAavENfzbUYkfPvu33sPgdM2TQhOaxr22I3JCNAqklZab5BxTfqYpdSxIXpY2hsXBlgZuvcbJ2bjXMD3Gycr1tnPw-GeYP-r_MrWXwBmAKBOQ</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Parlayan, Hanife Nur Karakoc</creator><creator>Solay, Asli Haykir</creator><creator>Aksoy, Begum Ruveyda</creator><creator>Bulut, Dilek</creator><creator>Hojabri, Mahsa</creator><creator>Sencan, Irfan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202412</creationdate><title>Clinical Insights and Outcomes in Community-Acquired Acute Bacterial Meningitis versus Postoperative Bacterial Meningitis</title><author>Parlayan, Hanife Nur Karakoc ; Solay, Asli Haykir ; Aksoy, Begum Ruveyda ; Bulut, Dilek ; Hojabri, Mahsa ; Sencan, Irfan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1451-a0ecef1641daa60c706074489b1d3df76b2e4a89835a68dd8a43d1e81dced9b83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Anti-Bacterial Agents - therapeutic use</topic><topic>Community-Acquired Infections - mortality</topic><topic>Female</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Male</topic><topic>Meningitis, Bacterial - cerebrospinal fluid</topic><topic>Meningitis, Bacterial - epidemiology</topic><topic>Meningitis, Bacterial - mortality</topic><topic>Middle Aged</topic><topic>Postoperative Complications - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Parlayan, Hanife Nur Karakoc</creatorcontrib><creatorcontrib>Solay, Asli Haykir</creatorcontrib><creatorcontrib>Aksoy, Begum Ruveyda</creatorcontrib><creatorcontrib>Bulut, Dilek</creatorcontrib><creatorcontrib>Hojabri, Mahsa</creatorcontrib><creatorcontrib>Sencan, Irfan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the College of Physicians and Surgeons--Pakistan</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Parlayan, Hanife Nur Karakoc</au><au>Solay, Asli Haykir</au><au>Aksoy, Begum Ruveyda</au><au>Bulut, Dilek</au><au>Hojabri, Mahsa</au><au>Sencan, Irfan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Insights and Outcomes in Community-Acquired Acute Bacterial Meningitis versus Postoperative Bacterial Meningitis</atitle><jtitle>Journal of the College of Physicians and Surgeons--Pakistan</jtitle><addtitle>J Coll Physicians Surg Pak</addtitle><date>2024-12</date><risdate>2024</risdate><volume>34</volume><issue>12</issue><spage>1441</spage><epage>1447</epage><pages>1441-1447</pages><issn>1022-386X</issn><issn>1681-7168</issn><eissn>1681-7168</eissn><abstract>To compare the demographics, clinical characteristics, and in-hospital mortality rates between community-acquired bacterial meningitis cases and postoperative bacterial meningitis.
Analytical study. Place and Duration of the Study: Department of Infectious Diseases and Clinical Microbiology, Diskapi Yildirim Beyazit Training and Research Hospital, Ankara, Turkiye, from 2016 to 2022.
A total of 153 patients diagnosed with bacterial meningitis were included and categorised into two groups: 95 (62.1%) with community-acquired bacterial meningitis (CABM) and 58 (37.9%) with postoperative bacterial meningitis (POBM). Demographics, clinical features, laboratory, paraclinical findings, treatments, and outcomes of the cases were compared. Data were retrieved using a standard data collection form from the electronic medical records.
A substantial portion (58.8%) of all patients had comorbidities. Fever was the common symptom in all groups. Headache, neck stiffness, nausea, and vomiting were more often observed in the CABM group (p <0.001). Upon admission, the CABM exhibited higher levels of white blood cell count, C-reactive protein, and procalcitonin (p = 0.017, p = 0.004, p = 0.007, respectively). Overall 33.1% had positive cerebrospinal fluid cultures. The overall mortality rate was 26.8%. POBM was associated with longer hospital and intensive care unit (ICU) stays (p <0.001). Shorter treatment durations, lower Glasgow coma scale scores (GCS), higher Charlson Comorbidity Index values, and elevated markers of inflammation were related to mortality.
This study illuminates the differences in clinical presentations and outcomes between community-acquired and postoperative bacterial meningitis. It also suggests that factors such as lower GCS scores, comorbidities, and elevated inflammation markers at the last follow-up may be associated with unfavourable clinical outcomes in bacterial meningitis.
Postoperative meningitis, Central nervous system infection, Cerebrospinal fluid, Antibiotics.</abstract><cop>Pakistan</cop><pmid>39648377</pmid><doi>10.29271/jcpsp.2024.12.1441</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Anti-Bacterial Agents - therapeutic use Community-Acquired Infections - mortality Female Hospital Mortality Humans Male Meningitis, Bacterial - cerebrospinal fluid Meningitis, Bacterial - epidemiology Meningitis, Bacterial - mortality Middle Aged Postoperative Complications - epidemiology |
| title | Clinical Insights and Outcomes in Community-Acquired Acute Bacterial Meningitis versus Postoperative Bacterial Meningitis |
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