A review on the biological activities and the nutraceutical potential of chitooligosaccharides
Chitooligosaccharides (CHOS) or chitosan oligosaccharides (COS) are oligomers mainly composed of d-glucosamine (GlcN) units and structured in a positively charged, basic, amino molecule obtained from the degradation of chitin/chitosan through physical, chemical, or enzymatic methods. CHOS display ph...
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| Veröffentlicht in: | Carbohydrate research 2025-02, Vol.548, p.109336, Article 109336 |
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| creator | Leal, Makyson R.S. Lima, Luiza R.A. Rodrigues, Natalie E.R. Soares, Paulo A.G. Carneiro-da-Cunha, Maria G. Albuquerque, Priscilla B.S. |
| description | Chitooligosaccharides (CHOS) or chitosan oligosaccharides (COS) are oligomers mainly composed of d-glucosamine (GlcN) units and structured in a positively charged, basic, amino molecule obtained from the degradation of chitin/chitosan through physical, chemical, or enzymatic methods. CHOS display physicochemical properties attractive to applications from the food to the biomedical field, such as non-toxicity to humans, high water solubility, low viscosity, biocompatibility, and biodegradability. These properties also allow CHOS to exert important biological activities, for example, antioxidant, antimicrobial, anti-inflammatory, immunomodulatory, antitumor, and hypocholesterolemic ones, besides to exhibit applications in food systems, technological, and nutraceutical potential. Therefore, this study summarized the synthesis and chemical structure, biological functions, and mechanisms of action of CHOS; with this, we aimed to contribute to the knowledge about the application of CHOS from the food to the biomedical industries.
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| doi_str_mv | 10.1016/j.carres.2024.109336 |
| format | Article |
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[Display omitted]</description><subject>Acid hydrolysis</subject><subject>Animals</subject><subject>Anti-Infective Agents - chemical synthesis</subject><subject>Anti-Infective Agents - chemistry</subject><subject>Anti-Infective Agents - pharmacology</subject><subject>Anti-Inflammatory Agents - chemistry</subject><subject>Anti-Inflammatory Agents - pharmacology</subject><subject>Antineoplastic Agents - chemical synthesis</subject><subject>Antineoplastic Agents - chemistry</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>antioxidants</subject><subject>Antioxidants - chemical synthesis</subject><subject>Antioxidants - chemistry</subject><subject>Antioxidants - pharmacology</subject><subject>biocompatibility</subject><subject>biodegradability</subject><subject>chemical structure</subject><subject>Chitin</subject><subject>Chitin - analogs & derivatives</subject><subject>Chitin - chemistry</subject><subject>Chitin - pharmacology</subject><subject>chitooligosaccharides</subject><subject>Chitosan</subject><subject>Chitosan - chemistry</subject><subject>Chitosan - pharmacology</subject><subject>Chitosan oligossacharides</subject><subject>Dietary Supplements</subject><subject>glucosamine</subject><subject>Humans</subject><subject>Immunologic Factors - chemical synthesis</subject><subject>Immunologic Factors - chemistry</subject><subject>Immunologic Factors - pharmacology</subject><subject>Oligosaccharides - chemical synthesis</subject><subject>Oligosaccharides - chemistry</subject><subject>Oligosaccharides - pharmacology</subject><subject>Positively charged structure</subject><subject>viscosity</subject><subject>water solubility</subject><issn>0008-6215</issn><issn>1873-426X</issn><issn>1873-426X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkU1P3DAQhq2qVdnS_gNU5dhLlvFHnOSChFChlZC4UIkTljOesF5l48V2qPrvmyXQY8Vpvp6Zkd6XsRMOaw5cn27XaGOktBYg1NxqpdTv2Io3tSyV0Hfv2QoAmlILXh2xTylt5xJ0rT-yI9lqWdcAK3Z_XkR68vS7CGORN1R0PgzhwaMdCovZP_nsKRV2dM_TccrRIk35GdiHTGP2cxb6Ajc-hzD4h5As4sZG7yh9Zh96OyT68hKP2a_L77cXP8rrm6ufF-fXJYpa5dL1RIq47KATyMnpSijRgxSib7sWuXSdqm2DyMHWnPcOQDWou5oDCa5BHrNvy919DI8TpWx2PiENgx0pTMlIXs2a8Kpp34AqXUnewgFVC4oxpBSpN_vodzb-MRzMwQSzNYsJ5mCCWUyY176-fJi6Hbl_S6-qz8DZAtAsySx-NAk9jUjOR8JsXPD___AXJruawA</recordid><startdate>20250201</startdate><enddate>20250201</enddate><creator>Leal, Makyson R.S.</creator><creator>Lima, Luiza R.A.</creator><creator>Rodrigues, Natalie E.R.</creator><creator>Soares, Paulo A.G.</creator><creator>Carneiro-da-Cunha, Maria G.</creator><creator>Albuquerque, Priscilla B.S.</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7S9</scope><scope>L.6</scope><orcidid>https://orcid.org/0000-0002-6310-1365</orcidid></search><sort><creationdate>20250201</creationdate><title>A review on the biological activities and the nutraceutical potential of chitooligosaccharides</title><author>Leal, Makyson R.S. ; 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CHOS display physicochemical properties attractive to applications from the food to the biomedical field, such as non-toxicity to humans, high water solubility, low viscosity, biocompatibility, and biodegradability. These properties also allow CHOS to exert important biological activities, for example, antioxidant, antimicrobial, anti-inflammatory, immunomodulatory, antitumor, and hypocholesterolemic ones, besides to exhibit applications in food systems, technological, and nutraceutical potential. Therefore, this study summarized the synthesis and chemical structure, biological functions, and mechanisms of action of CHOS; with this, we aimed to contribute to the knowledge about the application of CHOS from the food to the biomedical industries.
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| subjects | Acid hydrolysis Animals Anti-Infective Agents - chemical synthesis Anti-Infective Agents - chemistry Anti-Infective Agents - pharmacology Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - pharmacology Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - pharmacology antioxidants Antioxidants - chemical synthesis Antioxidants - chemistry Antioxidants - pharmacology biocompatibility biodegradability chemical structure Chitin Chitin - analogs & derivatives Chitin - chemistry Chitin - pharmacology chitooligosaccharides Chitosan Chitosan - chemistry Chitosan - pharmacology Chitosan oligossacharides Dietary Supplements glucosamine Humans Immunologic Factors - chemical synthesis Immunologic Factors - chemistry Immunologic Factors - pharmacology Oligosaccharides - chemical synthesis Oligosaccharides - chemistry Oligosaccharides - pharmacology Positively charged structure viscosity water solubility |
| title | A review on the biological activities and the nutraceutical potential of chitooligosaccharides |
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