Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) drives abnormal pericyte-rich vasculature in triple-negative breast cancer

Tumour angiogenesis supports malignant cells with oxygen and nutrients to promote invasion and metastasis. A number of cytokines released in situ participate in the recruitment of endothelial cells and pericytes to trigger the formation of novel blood vessels, which are often abnormal, leaky, and di...

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Veröffentlicht in:	Angiogenesis (London) 2025-03, Vol.28 (1), p.4, Article 4
Hauptverfasser:	Moro, Marianna, Balestrero, Federica Carolina, Colombo, Giorgia, Torretta, Simone, Clemente, Nausicaa, Ciccone, Valerio, Del Grosso, Erika, Donnini, Sandra, Travelli, Cristina, Condorelli, Fabrizio, Sangaletti, Sabina, Genazzani, Armando A., Grolla, Ambra A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Ablation Angiogenesis Animals Biomedical and Life Sciences Biomedicine Blood vessels Breast cancer Cancer Research Cardiology Cell Biology Cell Line, Tumor Chemokines Cytokines Endothelial cells Female Humans Inflammation Metastases Mice Monocyte chemoattractant protein 1 Neovascularization, Pathologic - metabolism Neovascularization, Pathologic - pathology NF-κB protein Nicotinamide Nicotinamide phosphoribosyltransferase Nicotinamide Phosphoribosyltransferase - metabolism Nutrients Oncology Ophthalmology Original Paper Pericytes Pericytes - drug effects Pericytes - metabolism Pericytes - pathology Phosphoribosyltransferase Platelet-derived growth factor Platelet-derived growth factor BB Protein turnover Synergism Triple Negative Breast Neoplasms - enzymology Triple Negative Breast Neoplasms - metabolism Triple Negative Breast Neoplasms - pathology Tumor Microenvironment Tumors
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