Characteristics and Risk Factors for Postoperative Bleeding Following Endoscopic Resection of Esophageal Squamous Neoplasms
Reports on postoperative bleeding after esophageal endoscopic resection are limited. This study aimed to identify the clinical characteristics and risk factors for postoperative bleeding following endoscopic resection of esophageal neoplasms. This single-center, retrospective study included consecut...
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| creator | Kitagawa, Daiki Kanesaka, Takashi Ishihara, Ryu Tani, Yasuhiro Okubo, Yuki Asada, Yuya Ueda, Tomoya Kizawa, Atsuko Ninomiya, Takehiro Ando, Yoshiaki Tanabe, Gentaro Fujimoto, Yuta Mori, Hitoshi Kato, Minoru Yoshii, Shunsuke Shichijo, Satoki Yamamoto, Sachiko Higashino, Koji Uedo, Noriya Michida, Tomoki Fujiwara, Yasuhiro |
| description | Reports on postoperative bleeding after esophageal endoscopic resection are limited.
This study aimed to identify the clinical characteristics and risk factors for postoperative bleeding following endoscopic resection of esophageal neoplasms.
This single-center, retrospective study included consecutive patients who underwent endoscopic resection for esophageal squamous cell carcinoma or squamous intraepithelial neoplasm between January 2018 and December 2022. We investigated the incidence, timing, severity, and risk factors for postoperative bleeding.
Of 1288 patients, 1062 (82%) underwent endoscopic submucosal dissection, and 226 (18%) underwent endoscopic mucosal resection. Postoperative bleeding occurred in seven (0.5%) patients (95% confidence interval [CI] 0.2-1.1%; median postoperative day 8 [range, 4-17 days]). In these seven patients, hemoglobin concentration decreased by a median of 3.0 g/dL (range, 1.6-6.8 g/dL). Antithrombotic agent use, resection wound circumference, and specimen size were significantly associated with postoperative bleeding (P |
| doi_str_mv | 10.1007/s10620-024-08776-0 |
| format | Article |
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This study aimed to identify the clinical characteristics and risk factors for postoperative bleeding following endoscopic resection of esophageal neoplasms.
This single-center, retrospective study included consecutive patients who underwent endoscopic resection for esophageal squamous cell carcinoma or squamous intraepithelial neoplasm between January 2018 and December 2022. We investigated the incidence, timing, severity, and risk factors for postoperative bleeding.
Of 1288 patients, 1062 (82%) underwent endoscopic submucosal dissection, and 226 (18%) underwent endoscopic mucosal resection. Postoperative bleeding occurred in seven (0.5%) patients (95% confidence interval [CI] 0.2-1.1%; median postoperative day 8 [range, 4-17 days]). In these seven patients, hemoglobin concentration decreased by a median of 3.0 g/dL (range, 1.6-6.8 g/dL). Antithrombotic agent use, resection wound circumference, and specimen size were significantly associated with postoperative bleeding (P < 0.001, P = 0.002, and P = 0.024, respectively). Among 43 patients who received direct oral anticoagulants (DOACs), postoperative bleeding occurred in four (9%) patients (95% CI 2.6-22.1%). DOACs were significantly associated with postoperative bleeding even after propensity score matching (4/40 [10%] vs. 0/80 [0%], respectively; P = 0.011).
The overall bleeding rate following esophageal endoscopic resection was 0.5%, with a delayed onset, leading to anemia. DOACs emerged as the most significant risk factor for postoperative bleeding.</description><identifier>ISSN: 0163-2116</identifier><identifier>ISSN: 1573-2568</identifier><identifier>EISSN: 1573-2568</identifier><identifier>DOI: 10.1007/s10620-024-08776-0</identifier><identifier>PMID: 39633230</identifier><language>eng</language><publisher>United States</publisher><ispartof>Digestive diseases and sciences, 2024-12</ispartof><rights>2024. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c184t-1cf1f46c8b468760a0a9842b094d977f7dc7a0c0c2a97935fb47dc2969831cad3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39633230$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kitagawa, Daiki</creatorcontrib><creatorcontrib>Kanesaka, Takashi</creatorcontrib><creatorcontrib>Ishihara, Ryu</creatorcontrib><creatorcontrib>Tani, Yasuhiro</creatorcontrib><creatorcontrib>Okubo, Yuki</creatorcontrib><creatorcontrib>Asada, Yuya</creatorcontrib><creatorcontrib>Ueda, Tomoya</creatorcontrib><creatorcontrib>Kizawa, Atsuko</creatorcontrib><creatorcontrib>Ninomiya, Takehiro</creatorcontrib><creatorcontrib>Ando, Yoshiaki</creatorcontrib><creatorcontrib>Tanabe, Gentaro</creatorcontrib><creatorcontrib>Fujimoto, Yuta</creatorcontrib><creatorcontrib>Mori, Hitoshi</creatorcontrib><creatorcontrib>Kato, Minoru</creatorcontrib><creatorcontrib>Yoshii, Shunsuke</creatorcontrib><creatorcontrib>Shichijo, Satoki</creatorcontrib><creatorcontrib>Yamamoto, Sachiko</creatorcontrib><creatorcontrib>Higashino, Koji</creatorcontrib><creatorcontrib>Uedo, Noriya</creatorcontrib><creatorcontrib>Michida, Tomoki</creatorcontrib><creatorcontrib>Fujiwara, Yasuhiro</creatorcontrib><title>Characteristics and Risk Factors for Postoperative Bleeding Following Endoscopic Resection of Esophageal Squamous Neoplasms</title><title>Digestive diseases and sciences</title><addtitle>Dig Dis Sci</addtitle><description>Reports on postoperative bleeding after esophageal endoscopic resection are limited.
This study aimed to identify the clinical characteristics and risk factors for postoperative bleeding following endoscopic resection of esophageal neoplasms.
This single-center, retrospective study included consecutive patients who underwent endoscopic resection for esophageal squamous cell carcinoma or squamous intraepithelial neoplasm between January 2018 and December 2022. We investigated the incidence, timing, severity, and risk factors for postoperative bleeding.
Of 1288 patients, 1062 (82%) underwent endoscopic submucosal dissection, and 226 (18%) underwent endoscopic mucosal resection. Postoperative bleeding occurred in seven (0.5%) patients (95% confidence interval [CI] 0.2-1.1%; median postoperative day 8 [range, 4-17 days]). In these seven patients, hemoglobin concentration decreased by a median of 3.0 g/dL (range, 1.6-6.8 g/dL). Antithrombotic agent use, resection wound circumference, and specimen size were significantly associated with postoperative bleeding (P < 0.001, P = 0.002, and P = 0.024, respectively). Among 43 patients who received direct oral anticoagulants (DOACs), postoperative bleeding occurred in four (9%) patients (95% CI 2.6-22.1%). DOACs were significantly associated with postoperative bleeding even after propensity score matching (4/40 [10%] vs. 0/80 [0%], respectively; P = 0.011).
The overall bleeding rate following esophageal endoscopic resection was 0.5%, with a delayed onset, leading to anemia. DOACs emerged as the most significant risk factor for postoperative bleeding.</description><issn>0163-2116</issn><issn>1573-2568</issn><issn>1573-2568</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNo9kEtPwzAQhC0EgvL4AxyQj1wC69i14yNULSBVgHicLddxwJDEwZuCEH-elAKnHY1mRquPkEMGJwxAnSIDmUMGucigUEpmsEFGbKx4lo9lsUlGwOSgGZM7ZBfxBQC0YnKb7HAtOc85jMjX5Nkm63qfAvbBIbVtSe8CvtLZ4MaEtIqJ3kbsY-eT7cO7p-e192Von-gs1nX8WKlpW0Z0sQuO3nn0rg-xpbGiU4zds33ytqb3b0vbxCXSax-72mKD-2SrsjX6g9-7Rx5n04fJZTa_ubianM0zxwrRZ8xVrBLSFQshCyXBgtWFyBegRamVqlTplAUHLrdaaT6uFmKwci11wZmzJd8jx-vdLsW3pcfeNAGdr2vb-uEhw5mQY6aVEEM0X0ddiojJV6ZLobHp0zAwK-hmDd0M0M0PdAND6eh3f7lofPlf-aPMvwHNbn8P</recordid><startdate>20241204</startdate><enddate>20241204</enddate><creator>Kitagawa, Daiki</creator><creator>Kanesaka, Takashi</creator><creator>Ishihara, Ryu</creator><creator>Tani, Yasuhiro</creator><creator>Okubo, Yuki</creator><creator>Asada, Yuya</creator><creator>Ueda, Tomoya</creator><creator>Kizawa, Atsuko</creator><creator>Ninomiya, Takehiro</creator><creator>Ando, Yoshiaki</creator><creator>Tanabe, Gentaro</creator><creator>Fujimoto, Yuta</creator><creator>Mori, Hitoshi</creator><creator>Kato, Minoru</creator><creator>Yoshii, Shunsuke</creator><creator>Shichijo, Satoki</creator><creator>Yamamoto, Sachiko</creator><creator>Higashino, Koji</creator><creator>Uedo, Noriya</creator><creator>Michida, Tomoki</creator><creator>Fujiwara, Yasuhiro</creator><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20241204</creationdate><title>Characteristics and Risk Factors for Postoperative Bleeding Following Endoscopic Resection of Esophageal Squamous Neoplasms</title><author>Kitagawa, Daiki ; Kanesaka, Takashi ; Ishihara, Ryu ; Tani, Yasuhiro ; Okubo, Yuki ; Asada, Yuya ; Ueda, Tomoya ; Kizawa, Atsuko ; Ninomiya, Takehiro ; Ando, Yoshiaki ; Tanabe, Gentaro ; Fujimoto, Yuta ; Mori, Hitoshi ; Kato, Minoru ; Yoshii, Shunsuke ; Shichijo, Satoki ; Yamamoto, Sachiko ; Higashino, Koji ; Uedo, Noriya ; Michida, Tomoki ; Fujiwara, Yasuhiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c184t-1cf1f46c8b468760a0a9842b094d977f7dc7a0c0c2a97935fb47dc2969831cad3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kitagawa, Daiki</creatorcontrib><creatorcontrib>Kanesaka, Takashi</creatorcontrib><creatorcontrib>Ishihara, Ryu</creatorcontrib><creatorcontrib>Tani, Yasuhiro</creatorcontrib><creatorcontrib>Okubo, Yuki</creatorcontrib><creatorcontrib>Asada, Yuya</creatorcontrib><creatorcontrib>Ueda, Tomoya</creatorcontrib><creatorcontrib>Kizawa, Atsuko</creatorcontrib><creatorcontrib>Ninomiya, Takehiro</creatorcontrib><creatorcontrib>Ando, Yoshiaki</creatorcontrib><creatorcontrib>Tanabe, Gentaro</creatorcontrib><creatorcontrib>Fujimoto, Yuta</creatorcontrib><creatorcontrib>Mori, Hitoshi</creatorcontrib><creatorcontrib>Kato, Minoru</creatorcontrib><creatorcontrib>Yoshii, Shunsuke</creatorcontrib><creatorcontrib>Shichijo, Satoki</creatorcontrib><creatorcontrib>Yamamoto, Sachiko</creatorcontrib><creatorcontrib>Higashino, Koji</creatorcontrib><creatorcontrib>Uedo, Noriya</creatorcontrib><creatorcontrib>Michida, Tomoki</creatorcontrib><creatorcontrib>Fujiwara, Yasuhiro</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive diseases and sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kitagawa, Daiki</au><au>Kanesaka, Takashi</au><au>Ishihara, Ryu</au><au>Tani, Yasuhiro</au><au>Okubo, Yuki</au><au>Asada, Yuya</au><au>Ueda, Tomoya</au><au>Kizawa, Atsuko</au><au>Ninomiya, Takehiro</au><au>Ando, Yoshiaki</au><au>Tanabe, Gentaro</au><au>Fujimoto, Yuta</au><au>Mori, Hitoshi</au><au>Kato, Minoru</au><au>Yoshii, Shunsuke</au><au>Shichijo, Satoki</au><au>Yamamoto, Sachiko</au><au>Higashino, Koji</au><au>Uedo, Noriya</au><au>Michida, Tomoki</au><au>Fujiwara, Yasuhiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Characteristics and Risk Factors for Postoperative Bleeding Following Endoscopic Resection of Esophageal Squamous Neoplasms</atitle><jtitle>Digestive diseases and sciences</jtitle><addtitle>Dig Dis Sci</addtitle><date>2024-12-04</date><risdate>2024</risdate><issn>0163-2116</issn><issn>1573-2568</issn><eissn>1573-2568</eissn><abstract>Reports on postoperative bleeding after esophageal endoscopic resection are limited.
This study aimed to identify the clinical characteristics and risk factors for postoperative bleeding following endoscopic resection of esophageal neoplasms.
This single-center, retrospective study included consecutive patients who underwent endoscopic resection for esophageal squamous cell carcinoma or squamous intraepithelial neoplasm between January 2018 and December 2022. We investigated the incidence, timing, severity, and risk factors for postoperative bleeding.
Of 1288 patients, 1062 (82%) underwent endoscopic submucosal dissection, and 226 (18%) underwent endoscopic mucosal resection. Postoperative bleeding occurred in seven (0.5%) patients (95% confidence interval [CI] 0.2-1.1%; median postoperative day 8 [range, 4-17 days]). In these seven patients, hemoglobin concentration decreased by a median of 3.0 g/dL (range, 1.6-6.8 g/dL). Antithrombotic agent use, resection wound circumference, and specimen size were significantly associated with postoperative bleeding (P < 0.001, P = 0.002, and P = 0.024, respectively). Among 43 patients who received direct oral anticoagulants (DOACs), postoperative bleeding occurred in four (9%) patients (95% CI 2.6-22.1%). DOACs were significantly associated with postoperative bleeding even after propensity score matching (4/40 [10%] vs. 0/80 [0%], respectively; P = 0.011).
The overall bleeding rate following esophageal endoscopic resection was 0.5%, with a delayed onset, leading to anemia. DOACs emerged as the most significant risk factor for postoperative bleeding.</abstract><cop>United States</cop><pmid>39633230</pmid><doi>10.1007/s10620-024-08776-0</doi></addata></record> |
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| title | Characteristics and Risk Factors for Postoperative Bleeding Following Endoscopic Resection of Esophageal Squamous Neoplasms |
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