Evaluating the impact of dermal absorption on internal doses of dechlorane plus in Chinese e-waste recycling employees
E-waste recycling employees represent a specific population with a high potential for exposure to dechlorane plus (DP). However, the impact of skin-adherent DP on human exposure within this group has not been well characterized. This study aimed to address this gap by collecting handwipe and matched...
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| Veröffentlicht in: | Chemosphere (Oxford) 2024-12, Vol.369, p.143883, Article 143883 |
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| creator | Wan, Yao-Yuan Cheng, Xiao-meng Li, Xing-Hong Wang, Feng-Shuang Li, Yuan-Yuan Li, Jing Qin, Zhan-Fen |
| description | E-waste recycling employees represent a specific population with a high potential for exposure to dechlorane plus (DP). However, the impact of skin-adherent DP on human exposure within this group has not been well characterized. This study aimed to address this gap by collecting handwipe and matched serum samples (n = 86 pairs) of Chinese e-waste recycling employees. In vivo human dermal bioavailability of DP was also examined to achieve effective exposure estimation. As a result, DP was detected in all handwipe and serum samples, indicating the occurrence of widespread exposure in the study population. For all the participants, the median level of ∑DP (the sum of syn-DP and anti-DP) in the serum was 45.1 ng g−1 lipid weight (lw), while handwipe samples showed the loading of 10.8 ng per wipe. Notably, significant associations were found between DP handwipe loadings and matched serum levels (p |
| doi_str_mv | 10.1016/j.chemosphere.2024.143883 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_3146517929</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0045653524027905</els_id><sourcerecordid>3146517929</sourcerecordid><originalsourceid>FETCH-LOGICAL-e1160-68c0b9662e1054ba911a364d72cd01eb736d44b5d0a17c98713f6bdc055fee3a3</originalsourceid><addsrcrecordid>eNpNkcFq3DAQhkVJaTZpX6Got1y80ViWbB3LkrSFQC7pWcjSbK1FtlzJ3rBvXy2bQGFgYPhm5p_5CfkGbAsM5P1hawccY54HTLitWd1soeFdxz-QDXStqqBW3RXZMNaISgourslNzgfGSrNQn8g1V5KDVGxDjg9HE1az-OkPXQakfpyNXWjcU4dpNIGaPsc0Lz5OtISfFkxTKbuYMV8wO4SYzIR0DmsuBN0NfsKMFKtXkxekCe3JhvMGHOcQT4j5M_m4NyHjl7d8S34_PrzsflZPzz9-7b4_VQggWSU7y3olZY3ARNMbBWC4bFxbW8cA-5ZL1zS9cMxAa1XXAt_L3lkmxB6RG35L7i5z5xT_rpgXPfpsMYSiN65Zc2ikgFbVqqBf39C1H9HpOfnRpJN-_1UBdhcAi-Cjx6Sz9ThZdL5cuGgXvQamzw7pg_7PIX12SF8c4v8A3e6IPw</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3146517929</pqid></control><display><type>article</type><title>Evaluating the impact of dermal absorption on internal doses of dechlorane plus in Chinese e-waste recycling employees</title><source>MEDLINE</source><source>ScienceDirect Journals (5 years ago - present)</source><creator>Wan, Yao-Yuan ; Cheng, Xiao-meng ; Li, Xing-Hong ; Wang, Feng-Shuang ; Li, Yuan-Yuan ; Li, Jing ; Qin, Zhan-Fen</creator><creatorcontrib>Wan, Yao-Yuan ; Cheng, Xiao-meng ; Li, Xing-Hong ; Wang, Feng-Shuang ; Li, Yuan-Yuan ; Li, Jing ; Qin, Zhan-Fen</creatorcontrib><description>E-waste recycling employees represent a specific population with a high potential for exposure to dechlorane plus (DP). However, the impact of skin-adherent DP on human exposure within this group has not been well characterized. This study aimed to address this gap by collecting handwipe and matched serum samples (n = 86 pairs) of Chinese e-waste recycling employees. In vivo human dermal bioavailability of DP was also examined to achieve effective exposure estimation. As a result, DP was detected in all handwipe and serum samples, indicating the occurrence of widespread exposure in the study population. For all the participants, the median level of ∑DP (the sum of syn-DP and anti-DP) in the serum was 45.1 ng g−1 lipid weight (lw), while handwipe samples showed the loading of 10.8 ng per wipe. Notably, significant associations were found between DP handwipe loadings and matched serum levels (p<0.05). Next, the in vivo human dermal bioavailability was estimated to be 9.54% for ∑DP. Based on this value, the estimated average daily dose was 0.231 ng kg−1 d−1 (median values), contributing 10.9% to serum levels of ∑DP. The significant associations and 10.9% percentage contribution together underscore the non-negligible influence of dermal absorption on DP internal doses in the e-waste recycling employees. Moreover, the extremely high levels of DP (up to 3.64E+04 ng g−1 lw) detected in serum highlight the extent of DP accumulation in humans. Continuous monitoring and assessment are warranted among e-waste workers due to the persistent organic pollutant properties of DP.
[Display omitted]
•The non-negligible influence of dermal exposure to dechlorane plus (DP) was identified on e-waste recycling population.•The in vivo human bioavailability was estimated to be 9.54% for ∑DP by the parallelogram approach.•Unexpectedly high serum levels of DP (dozens of μg g−1 lw) was found in human beings.</description><identifier>ISSN: 0045-6535</identifier><identifier>ISSN: 1879-1298</identifier><identifier>EISSN: 1879-1298</identifier><identifier>DOI: 10.1016/j.chemosphere.2024.143883</identifier><identifier>PMID: 39631690</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adult ; China ; Dechlorane plus ; Dermal exposure ; e-waste recycling employees ; East Asian People ; Electronic Waste ; Environmental Monitoring ; Female ; Humans ; Hydrocarbons, Chlorinated - blood ; In vivo human bioavailability ; Male ; Middle Aged ; Occupational Exposure - analysis ; Occupational Exposure - statistics & numerical data ; Polycyclic Compounds ; Recycling ; Serum and handwipe samples ; Skin Absorption ; Young Adult</subject><ispartof>Chemosphere (Oxford), 2024-12, Vol.369, p.143883, Article 143883</ispartof><rights>2024 Elsevier Ltd</rights><rights>Copyright © 2024 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0009-0006-2392-6940</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.chemosphere.2024.143883$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39631690$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wan, Yao-Yuan</creatorcontrib><creatorcontrib>Cheng, Xiao-meng</creatorcontrib><creatorcontrib>Li, Xing-Hong</creatorcontrib><creatorcontrib>Wang, Feng-Shuang</creatorcontrib><creatorcontrib>Li, Yuan-Yuan</creatorcontrib><creatorcontrib>Li, Jing</creatorcontrib><creatorcontrib>Qin, Zhan-Fen</creatorcontrib><title>Evaluating the impact of dermal absorption on internal doses of dechlorane plus in Chinese e-waste recycling employees</title><title>Chemosphere (Oxford)</title><addtitle>Chemosphere</addtitle><description>E-waste recycling employees represent a specific population with a high potential for exposure to dechlorane plus (DP). However, the impact of skin-adherent DP on human exposure within this group has not been well characterized. This study aimed to address this gap by collecting handwipe and matched serum samples (n = 86 pairs) of Chinese e-waste recycling employees. In vivo human dermal bioavailability of DP was also examined to achieve effective exposure estimation. As a result, DP was detected in all handwipe and serum samples, indicating the occurrence of widespread exposure in the study population. For all the participants, the median level of ∑DP (the sum of syn-DP and anti-DP) in the serum was 45.1 ng g−1 lipid weight (lw), while handwipe samples showed the loading of 10.8 ng per wipe. Notably, significant associations were found between DP handwipe loadings and matched serum levels (p<0.05). Next, the in vivo human dermal bioavailability was estimated to be 9.54% for ∑DP. Based on this value, the estimated average daily dose was 0.231 ng kg−1 d−1 (median values), contributing 10.9% to serum levels of ∑DP. The significant associations and 10.9% percentage contribution together underscore the non-negligible influence of dermal absorption on DP internal doses in the e-waste recycling employees. Moreover, the extremely high levels of DP (up to 3.64E+04 ng g−1 lw) detected in serum highlight the extent of DP accumulation in humans. Continuous monitoring and assessment are warranted among e-waste workers due to the persistent organic pollutant properties of DP.
[Display omitted]
•The non-negligible influence of dermal exposure to dechlorane plus (DP) was identified on e-waste recycling population.•The in vivo human bioavailability was estimated to be 9.54% for ∑DP by the parallelogram approach.•Unexpectedly high serum levels of DP (dozens of μg g−1 lw) was found in human beings.</description><subject>Adult</subject><subject>China</subject><subject>Dechlorane plus</subject><subject>Dermal exposure</subject><subject>e-waste recycling employees</subject><subject>East Asian People</subject><subject>Electronic Waste</subject><subject>Environmental Monitoring</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrocarbons, Chlorinated - blood</subject><subject>In vivo human bioavailability</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Occupational Exposure - analysis</subject><subject>Occupational Exposure - statistics & numerical data</subject><subject>Polycyclic Compounds</subject><subject>Recycling</subject><subject>Serum and handwipe samples</subject><subject>Skin Absorption</subject><subject>Young Adult</subject><issn>0045-6535</issn><issn>1879-1298</issn><issn>1879-1298</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkcFq3DAQhkVJaTZpX6Got1y80ViWbB3LkrSFQC7pWcjSbK1FtlzJ3rBvXy2bQGFgYPhm5p_5CfkGbAsM5P1hawccY54HTLitWd1soeFdxz-QDXStqqBW3RXZMNaISgourslNzgfGSrNQn8g1V5KDVGxDjg9HE1az-OkPXQakfpyNXWjcU4dpNIGaPsc0Lz5OtISfFkxTKbuYMV8wO4SYzIR0DmsuBN0NfsKMFKtXkxekCe3JhvMGHOcQT4j5M_m4NyHjl7d8S34_PrzsflZPzz9-7b4_VQggWSU7y3olZY3ARNMbBWC4bFxbW8cA-5ZL1zS9cMxAa1XXAt_L3lkmxB6RG35L7i5z5xT_rpgXPfpsMYSiN65Zc2ikgFbVqqBf39C1H9HpOfnRpJN-_1UBdhcAi-Cjx6Sz9ThZdL5cuGgXvQamzw7pg_7PIX12SF8c4v8A3e6IPw</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Wan, Yao-Yuan</creator><creator>Cheng, Xiao-meng</creator><creator>Li, Xing-Hong</creator><creator>Wang, Feng-Shuang</creator><creator>Li, Yuan-Yuan</creator><creator>Li, Jing</creator><creator>Qin, Zhan-Fen</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><orcidid>https://orcid.org/0009-0006-2392-6940</orcidid></search><sort><creationdate>202412</creationdate><title>Evaluating the impact of dermal absorption on internal doses of dechlorane plus in Chinese e-waste recycling employees</title><author>Wan, Yao-Yuan ; Cheng, Xiao-meng ; Li, Xing-Hong ; Wang, Feng-Shuang ; Li, Yuan-Yuan ; Li, Jing ; Qin, Zhan-Fen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e1160-68c0b9662e1054ba911a364d72cd01eb736d44b5d0a17c98713f6bdc055fee3a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>China</topic><topic>Dechlorane plus</topic><topic>Dermal exposure</topic><topic>e-waste recycling employees</topic><topic>East Asian People</topic><topic>Electronic Waste</topic><topic>Environmental Monitoring</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrocarbons, Chlorinated - blood</topic><topic>In vivo human bioavailability</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Occupational Exposure - analysis</topic><topic>Occupational Exposure - statistics & numerical data</topic><topic>Polycyclic Compounds</topic><topic>Recycling</topic><topic>Serum and handwipe samples</topic><topic>Skin Absorption</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wan, Yao-Yuan</creatorcontrib><creatorcontrib>Cheng, Xiao-meng</creatorcontrib><creatorcontrib>Li, Xing-Hong</creatorcontrib><creatorcontrib>Wang, Feng-Shuang</creatorcontrib><creatorcontrib>Li, Yuan-Yuan</creatorcontrib><creatorcontrib>Li, Jing</creatorcontrib><creatorcontrib>Qin, Zhan-Fen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Chemosphere (Oxford)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wan, Yao-Yuan</au><au>Cheng, Xiao-meng</au><au>Li, Xing-Hong</au><au>Wang, Feng-Shuang</au><au>Li, Yuan-Yuan</au><au>Li, Jing</au><au>Qin, Zhan-Fen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Evaluating the impact of dermal absorption on internal doses of dechlorane plus in Chinese e-waste recycling employees</atitle><jtitle>Chemosphere (Oxford)</jtitle><addtitle>Chemosphere</addtitle><date>2024-12</date><risdate>2024</risdate><volume>369</volume><spage>143883</spage><pages>143883-</pages><artnum>143883</artnum><issn>0045-6535</issn><issn>1879-1298</issn><eissn>1879-1298</eissn><abstract>E-waste recycling employees represent a specific population with a high potential for exposure to dechlorane plus (DP). However, the impact of skin-adherent DP on human exposure within this group has not been well characterized. This study aimed to address this gap by collecting handwipe and matched serum samples (n = 86 pairs) of Chinese e-waste recycling employees. In vivo human dermal bioavailability of DP was also examined to achieve effective exposure estimation. As a result, DP was detected in all handwipe and serum samples, indicating the occurrence of widespread exposure in the study population. For all the participants, the median level of ∑DP (the sum of syn-DP and anti-DP) in the serum was 45.1 ng g−1 lipid weight (lw), while handwipe samples showed the loading of 10.8 ng per wipe. Notably, significant associations were found between DP handwipe loadings and matched serum levels (p<0.05). Next, the in vivo human dermal bioavailability was estimated to be 9.54% for ∑DP. Based on this value, the estimated average daily dose was 0.231 ng kg−1 d−1 (median values), contributing 10.9% to serum levels of ∑DP. The significant associations and 10.9% percentage contribution together underscore the non-negligible influence of dermal absorption on DP internal doses in the e-waste recycling employees. Moreover, the extremely high levels of DP (up to 3.64E+04 ng g−1 lw) detected in serum highlight the extent of DP accumulation in humans. Continuous monitoring and assessment are warranted among e-waste workers due to the persistent organic pollutant properties of DP.
[Display omitted]
•The non-negligible influence of dermal exposure to dechlorane plus (DP) was identified on e-waste recycling population.•The in vivo human bioavailability was estimated to be 9.54% for ∑DP by the parallelogram approach.•Unexpectedly high serum levels of DP (dozens of μg g−1 lw) was found in human beings.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>39631690</pmid><doi>10.1016/j.chemosphere.2024.143883</doi><orcidid>https://orcid.org/0009-0006-2392-6940</orcidid></addata></record> |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Adult China Dechlorane plus Dermal exposure e-waste recycling employees East Asian People Electronic Waste Environmental Monitoring Female Humans Hydrocarbons, Chlorinated - blood In vivo human bioavailability Male Middle Aged Occupational Exposure - analysis Occupational Exposure - statistics & numerical data Polycyclic Compounds Recycling Serum and handwipe samples Skin Absorption Young Adult |
| title | Evaluating the impact of dermal absorption on internal doses of dechlorane plus in Chinese e-waste recycling employees |
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