Genetic and microenvironmental evolution of colorectal liver metastases under chemotherapy

Drug resistance limits the efficacy of chemotherapy for colorectal cancer liver metastasis (CRLM). However, the evolution of CRLM during drug treatment remains poorly elucidated. Multi-omics and treatment response data from 115 samples of 49 patients with CRLM undergoing bevacizumab (BVZ)-based chem...

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Veröffentlicht in:	Cell reports. Medicine 2024-12, Vol.5 (12), p.101838, Article 101838
Hauptverfasser:	Shi, Min, Yang, Yingxi, Huang, Na, Zeng, Dongqiang, Mo, Zongchao, Wang, Jiao, Zhang, Xiaomeng, Liu, Ran, Wang, Chunlin, Rong, Xiaoxiang, Wu, Zhenzhen, Huang, Qiong, Shang, Haixia, Tang, Jihong, Wang, Zhaojun, Cai, Jianan, Huang, Genjie, Guan, Yijin, Guo, Jian, Mu, Quanhua, Wang, Jiguang, Liao, Wangjun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Bevacizumab Bevacizumab - pharmacology Bevacizumab - therapeutic use cancer genomics Cell Line, Tumor chemoresistance chr20q copy-number gain colorectal liver metastases Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Drug Resistance, Neoplasm - genetics Female Fluorouracil - pharmacology Fluorouracil - therapeutic use Gene Expression Regulation, Neoplastic - drug effects Humans Liver Neoplasms - drug therapy Liver Neoplasms - genetics Liver Neoplasms - secondary Male Mutation - genetics Signal Transduction - drug effects SMAD4 mutation Smad4 Protein - genetics Smad4 Protein - metabolism STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism tumor microenvironment Tumor Microenvironment - drug effects Tumor Microenvironment - genetics
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