YAP1 induces bladder cancer progression and promotes immune evasion through IL-6/STAT3 pathway and CXCL deregulation

The Hippo signaling pathway plays a key role in tumorigenesis in different cancer types. We investigated the role of the Hippo effector YAP1 in the tumor immune microenvironment (TIME) of urothelial carcinoma of the bladder (UCB) and evaluated the efficacy of immunotherapy in the context of YAP1 sig...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of clinical investigation 2024-12, Vol.135 (2)
Hauptverfasser:	Sadhukhan, Pritam, Feng, Mingxiao, Illingworth, Emily, Sloma, Ido, Ooki, Akira, Matoso, Andres, Sidransky, David, Johnson, 3rd, Burles A, Marchionni, Luigi, Sillé, Fenna Cm, Choi, Woonyoung, McConkey, David, Hoque, Mohammad
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing - genetics Adaptor Proteins, Signal Transducing - immunology Adaptor Proteins, Signal Transducing - metabolism Animals Cell Line, Tumor Gene Expression Regulation, Neoplastic Humans Interleukin-6 - genetics Interleukin-6 - immunology Interleukin-6 - metabolism Mice Neoplasm Proteins - genetics Neoplasm Proteins - immunology Neoplasm Proteins - metabolism Signal Transduction - immunology STAT3 Transcription Factor - genetics STAT3 Transcription Factor - immunology STAT3 Transcription Factor - metabolism Transcription Factors - genetics Transcription Factors - immunology Transcription Factors - metabolism Tumor Escape Tumor Microenvironment - immunology Urinary Bladder Neoplasms - genetics Urinary Bladder Neoplasms - immunology Urinary Bladder Neoplasms - metabolism Urinary Bladder Neoplasms - pathology YAP-Signaling Proteins - genetics
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!