Long term Coptidis Rhizoma intake induce gastrointestinal emptying inhibition and colon barrier weaken via bitter taste receptors activation in mice

•Long term Coptidis Rhizoma intake induce gastrointestinal emptying inhibition and colon barrier weaken.•Rhizoma alkaloids are agonists for bitter taste receptors.•Coptidis Rhizoma induce gastrointestinal emptying inhibition via promoting α-gustducin binding to CHRM3 caused by activating bitter tast...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Phytomedicine (Stuttgart) 2024-11, Vol.136, p.156292, Article 156292
Hauptverfasser:	Wu, Zhizhongbin, Yang, Wei, Wu, Tianyue, Liu, Yulin, Pu, Yu, Hu, Weiqing, Jiang, Yunbin, Zhang, Jifen, Zhu, Huifeng, Li, Xuegang, Feng, Shan
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids Bitter taste receptors Colon barrier Coptidis Rhizoma Gastrointestinal emptying function
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!