TFPI2 hypermethylation promotes diabetic atherosclerosis progression through the Ap2α/PPARγ axis

Diabetes mellitus significantly escalates the risk of accelerated atherosclerosis (AS), severely affecting cardiovascular health. Our research, leveraging Gene Expression Omnibus (GEO) database analysis (GSE118481), revealed diminished TFPI2 expression in diabetic patients' atherosclerotic plaq...

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Veröffentlicht in:	Journal of molecular and cellular cardiology 2025-01, Vol.198, p.45-59
Hauptverfasser:	Xia, Zongyi, Zhou, Chi, Hong, Yefeng, Li, Fuhai, Zhang, Wenzhong, Ji, Hongwei, Xiao, Yu, Li, Shifang, Li, Shufa, Lu, Xiaohong, Li, Shaohua, Tan, Kai, Xin, Hui, Wang, Zhaoyang, Lian, Zhenxun, Guo, Mengqi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Atherosclerosis Atherosclerosis - genetics Atherosclerosis - metabolism Atherosclerosis - pathology Diabetes mellitus Diabetes Mellitus, Experimental - genetics Diabetes Mellitus, Experimental - metabolism Disease Progression DNA Methylation DNA methyltransferase 1 Fatty Acid-Binding Proteins Gene Expression Regulation Glycoproteins - genetics Glycoproteins - metabolism Humans Macrophage Macrophages - metabolism Male Mice Mice, Inbred C57BL Peroxisome proliferator-activated receptor gamma Plaque, Atherosclerotic - genetics Plaque, Atherosclerotic - metabolism Plaque, Atherosclerotic - pathology PPAR gamma - genetics PPAR gamma - metabolism Promoter Regions, Genetic Signal Transduction Tissue factor pathway inhibitor-2 Transcription Factor AP-2 - genetics Transcription Factor AP-2 - metabolism
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