Two-ended recombination at a Flp-nickase-broken replication fork

Replication fork collision with a DNA nick can generate a one-ended break, fostering genomic instability. The opposing fork’s collision with the nick could form a second DNA end, enabling conservative repair by homologous recombination (HR). To study mechanisms of nickase-induced HR, we developed th...

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Veröffentlicht in:	Molecular cell 2025-01, Vol.85 (1), p.78-90.e3
Hauptverfasser:	Elango, Rajula, Nilavar, Namrata M., Li, Andrew G., Nguyen, Daniel, Rass, Emilie, Duffey, Erin E., Jiang, Yuning, Abakir, Abdulkadir, Willis, Nicholas A., Houseley, Jonathan, Scully, Ralph
Format:	Artikel
Sprache:	eng
Schlagworte:	BRCA1 BRCA1 Protein - genetics BRCA1 Protein - metabolism BRCA2 Protein - genetics BRCA2 Protein - metabolism break-induced replication Camptothecin Carrier Proteins - genetics Carrier Proteins - metabolism Deoxyribonuclease I - genetics Deoxyribonuclease I - metabolism DNA nick DNA Nucleotidyltransferases - genetics DNA Nucleotidyltransferases - metabolism DNA Replication DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism DNA-protein crosslink Endodeoxyribonucleases Flp recombinase Gene Conversion Genomic Instability Homologous Recombination Humans MRE11 Homologue Protein - genetics MRE11 Homologue Protein - metabolism Nuclear Proteins - genetics Nuclear Proteins - metabolism Rad51 Recombinase - genetics Rad51 Recombinase - metabolism replication fork breakage replication stress Tus/Ter
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