Structural and mechanism-based engineering of sulfotransferase CHST15 for the efficient synthesis of chondroitin sulfate E

Natural chondroitin sulfate (CS), extracted from animal cartilage, is widely used in the pharmaceuticals and foods. However, contamination with animal-derived heteropolysaccharides presents significant challenges, including potential immune responses. To address this, we developed a green and effici...

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Veröffentlicht in:	Applied and environmental microbiology 2024-12, Vol.91 (1), p.e0157324
Hauptverfasser:	Wang, Zhonghua, Song, Wei, Wei, Wanqing, Qi, Hejia, Meng, Weiwei, Liu, Jia, Li, Xiaomin, Gao, Cong, Liu, Liming, Hu, Guipeng, Zhou, Yiwen, Wu, Jing
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - chemistry Bacterial Proteins - genetics Bacterial Proteins - metabolism Biotechnology Catalytic converters Chemical synthesis Chondroitin sulfate Chondroitin Sulfates - biosynthesis Chondroitin Sulfates - chemistry Chondroitin Sulfates - metabolism Enzymatic synthesis Escherichia coli - genetics Escherichia coli - metabolism Food contamination Immune response Industrial production Protein Engineering Protein folding Quantum mechanics Reaction mechanisms Sulfates Sulfotransferase Sulfotransferases - chemistry Sulfotransferases - genetics Sulfotransferases - metabolism
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