Programmable Multiplexed Nucleic Acid Detection by Harnessing Specificity Defect of CRISPR-Cas12a

CRISPR-Cas12a works like a sophisticated algorithm in nucleic acid detection, yet its challenge lies in sometimes failing to distinguish targets with mismatches due to its specificity limitations. Here, the mismatch profiles, including the quantity, location, and type of mismatches in the CRISPR-Cas...

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Veröffentlicht in:	Advanced science 2024-12, p.e2411021
Hauptverfasser:	Guan, Xin, Yang, Rui, Zhang, Jiongyu, Moon, Jeong, Hou, Chengyu, Guo, Chong, Avery, Lori, Scarola, Danielle, Roberts, Daniel S, LaSala, Rocco, Liu, Changchun
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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