Utilizing an Opportunistic Clinical Study and Population-Based Pharmacokinetic Models to Identify Rational Empiric Dosing Regimens for Piperacillin-Tazobactam in Critically Ill Patients

Determining an effective dosing regimen for piperacillin-tazobactam in critically ill patients is challenging due to substantial pharmacokinetic variability caused by complex pathophysiological changes. To address this need, a prospective clinical study was conducted, which enrolled 112 critically i...

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Veröffentlicht in:	Journal of clinical pharmacology 2024-12
Hauptverfasser:	Reeder, Joshua A, Creech, C Buddy, Nation, Roger L, Gu, Kenan, Nalbant, Demet, Wu, Nan, Jimenez-Truque, Natalia, Fissell, William, Rolsma, Stephanie L, Fishbane, Nicholas, Kirkpatrick, Carl M J, Patel, Pratish C, Watanabe, Amy, Landersdorfer, Cornelia B, Winokur, Patricia, An, Guohua
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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