Visualizing motions within the cochlea's organ of Corti and illuminating cochlear mechanics with optical coherence tomography
•OCT can detect motions of cells and structures within the sensory tissue of the cochlea.•Structures within the sensory tissue move differently than the basilar membrane.•OHCs show active motion to frequencies well below the best frequency.•Perturbations related to deafness modify motions within the...
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| Veröffentlicht in: | Hearing research 2025-01, Vol.455, p.109154, Article 109154 |
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| container_title | Hearing research |
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| creator | Olson, Elizabeth S. Dong, Wei Applegate, Brian E. Charaziak, Karolina K. Dewey, James B. Frost, Brian L. Meenderink, Sebastiaan W.F. Nam, Jong-Hoon Oghalai, John S. Puria, Sunil Ren, Tianying Strimbu, C. Elliott van der Heijden, Marcel |
| description | •OCT can detect motions of cells and structures within the sensory tissue of the cochlea.•Structures within the sensory tissue move differently than the basilar membrane.•OHCs show active motion to frequencies well below the best frequency.•Perturbations related to deafness modify motions within the sensory tissue.•Motion within the sensory tissue is related to otoacoustic emissions.
Beginning in 2006, optical coherence tomography (OCT) has been adapted for use as a vibrometer for hearing research. The application of OCT in this field, particularly for studying cochlear mechanics, represents a revolutionary advance over previous technologies. OCT provides detailed evidence of the motions of components within the organ of Corti, extending beyond the first-encountered surface of observation. By imaging through the bony capsule as well as through the round window membrane, OCT has measured vibration at multiple locations along the cochlear spiral, in vivo, under nearly natural conditions. In this document, we present examples of recent research findings to illustrate the applications of OCT in studying cochlear mechanics in both normal and impaired ears. |
| doi_str_mv | 10.1016/j.heares.2024.109154 |
| format | Article |
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Beginning in 2006, optical coherence tomography (OCT) has been adapted for use as a vibrometer for hearing research. The application of OCT in this field, particularly for studying cochlear mechanics, represents a revolutionary advance over previous technologies. OCT provides detailed evidence of the motions of components within the organ of Corti, extending beyond the first-encountered surface of observation. By imaging through the bony capsule as well as through the round window membrane, OCT has measured vibration at multiple locations along the cochlear spiral, in vivo, under nearly natural conditions. In this document, we present examples of recent research findings to illustrate the applications of OCT in studying cochlear mechanics in both normal and impaired ears.</description><identifier>ISSN: 0378-5955</identifier><identifier>ISSN: 1878-5891</identifier><identifier>EISSN: 1878-5891</identifier><identifier>DOI: 10.1016/j.heares.2024.109154</identifier><identifier>PMID: 39626338</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Biomechanical Phenomena ; Cochlea - diagnostic imaging ; Cochlea - physiology ; Hearing ; Humans ; Motion ; Organ of Corti - diagnostic imaging ; Organ of Corti - physiology ; Tomography, Optical Coherence ; Vibration</subject><ispartof>Hearing research, 2025-01, Vol.455, p.109154, Article 109154</ispartof><rights>2024 Elsevier B.V.</rights><rights>Copyright © 2024 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c241t-9ea74653428c2c027228acef97fd35949d17bd7e707259d9725f0f1f85c97b023</cites><orcidid>0000-0002-3586-7769</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0378595524002077$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39626338$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Olson, Elizabeth S.</creatorcontrib><creatorcontrib>Dong, Wei</creatorcontrib><creatorcontrib>Applegate, Brian E.</creatorcontrib><creatorcontrib>Charaziak, Karolina K.</creatorcontrib><creatorcontrib>Dewey, James B.</creatorcontrib><creatorcontrib>Frost, Brian L.</creatorcontrib><creatorcontrib>Meenderink, Sebastiaan W.F.</creatorcontrib><creatorcontrib>Nam, Jong-Hoon</creatorcontrib><creatorcontrib>Oghalai, John S.</creatorcontrib><creatorcontrib>Puria, Sunil</creatorcontrib><creatorcontrib>Ren, Tianying</creatorcontrib><creatorcontrib>Strimbu, C. Elliott</creatorcontrib><creatorcontrib>van der Heijden, Marcel</creatorcontrib><title>Visualizing motions within the cochlea's organ of Corti and illuminating cochlear mechanics with optical coherence tomography</title><title>Hearing research</title><addtitle>Hear Res</addtitle><description>•OCT can detect motions of cells and structures within the sensory tissue of the cochlea.•Structures within the sensory tissue move differently than the basilar membrane.•OHCs show active motion to frequencies well below the best frequency.•Perturbations related to deafness modify motions within the sensory tissue.•Motion within the sensory tissue is related to otoacoustic emissions.
Beginning in 2006, optical coherence tomography (OCT) has been adapted for use as a vibrometer for hearing research. The application of OCT in this field, particularly for studying cochlear mechanics, represents a revolutionary advance over previous technologies. OCT provides detailed evidence of the motions of components within the organ of Corti, extending beyond the first-encountered surface of observation. By imaging through the bony capsule as well as through the round window membrane, OCT has measured vibration at multiple locations along the cochlear spiral, in vivo, under nearly natural conditions. In this document, we present examples of recent research findings to illustrate the applications of OCT in studying cochlear mechanics in both normal and impaired ears.</description><subject>Animals</subject><subject>Biomechanical Phenomena</subject><subject>Cochlea - diagnostic imaging</subject><subject>Cochlea - physiology</subject><subject>Hearing</subject><subject>Humans</subject><subject>Motion</subject><subject>Organ of Corti - diagnostic imaging</subject><subject>Organ of Corti - physiology</subject><subject>Tomography, Optical Coherence</subject><subject>Vibration</subject><issn>0378-5955</issn><issn>1878-5891</issn><issn>1878-5891</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1P4zAQhi20Kygf_wAh33YvLbaT1PEFCVW7gITEBbharjNppkrsYjusQNr_TqIUjlxsa_y8M_ZDyDlnC8748nK7aMAEiAvBRD6UFC_yAzLjpSznRan4DzJj2XhWRXFEjmPcMsaLLBeH5ChTS7HMsnJG_j9j7E2L7-g2tPMJvYv0H6YGHU0NUOtt04L5FakPG-Oor-nKh4TUuIpi2_YdOpPG8J4MtAPbGId26kP9LqE17XDfQABngSbf-U0wu-btlPysTRvhbL-fkKe_fx5Xt_P7h5u71fX93Iqcp7kCI_Pl-PbSCsuEFKI0Fmol6yorVK4qLteVBMmkKFSlhrVmNa_Lwiq5ZiI7Ib-nvrvgX3qISXcYLbStceD7qDOeMyXkoHVA8wm1wccYoNa7gJ0Jb5ozPYrXWz2J16N4PYkfYhf7Cf26g-or9Gl6AK4mAIZ_viIEHS2OOioMYJOuPH4_4QMoy5f3</recordid><startdate>202501</startdate><enddate>202501</enddate><creator>Olson, Elizabeth S.</creator><creator>Dong, Wei</creator><creator>Applegate, Brian E.</creator><creator>Charaziak, Karolina K.</creator><creator>Dewey, James B.</creator><creator>Frost, Brian L.</creator><creator>Meenderink, Sebastiaan W.F.</creator><creator>Nam, Jong-Hoon</creator><creator>Oghalai, John S.</creator><creator>Puria, Sunil</creator><creator>Ren, Tianying</creator><creator>Strimbu, C. Elliott</creator><creator>van der Heijden, Marcel</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-3586-7769</orcidid></search><sort><creationdate>202501</creationdate><title>Visualizing motions within the cochlea's organ of Corti and illuminating cochlear mechanics with optical coherence tomography</title><author>Olson, Elizabeth S. ; Dong, Wei ; Applegate, Brian E. ; Charaziak, Karolina K. ; Dewey, James B. ; Frost, Brian L. ; Meenderink, Sebastiaan W.F. ; Nam, Jong-Hoon ; Oghalai, John S. ; Puria, Sunil ; Ren, Tianying ; Strimbu, C. 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Elliott</creatorcontrib><creatorcontrib>van der Heijden, Marcel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Hearing research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Olson, Elizabeth S.</au><au>Dong, Wei</au><au>Applegate, Brian E.</au><au>Charaziak, Karolina K.</au><au>Dewey, James B.</au><au>Frost, Brian L.</au><au>Meenderink, Sebastiaan W.F.</au><au>Nam, Jong-Hoon</au><au>Oghalai, John S.</au><au>Puria, Sunil</au><au>Ren, Tianying</au><au>Strimbu, C. 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Beginning in 2006, optical coherence tomography (OCT) has been adapted for use as a vibrometer for hearing research. The application of OCT in this field, particularly for studying cochlear mechanics, represents a revolutionary advance over previous technologies. OCT provides detailed evidence of the motions of components within the organ of Corti, extending beyond the first-encountered surface of observation. By imaging through the bony capsule as well as through the round window membrane, OCT has measured vibration at multiple locations along the cochlear spiral, in vivo, under nearly natural conditions. In this document, we present examples of recent research findings to illustrate the applications of OCT in studying cochlear mechanics in both normal and impaired ears.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>39626338</pmid><doi>10.1016/j.heares.2024.109154</doi><orcidid>https://orcid.org/0000-0002-3586-7769</orcidid></addata></record> |
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| subjects | Animals Biomechanical Phenomena Cochlea - diagnostic imaging Cochlea - physiology Hearing Humans Motion Organ of Corti - diagnostic imaging Organ of Corti - physiology Tomography, Optical Coherence Vibration |
| title | Visualizing motions within the cochlea's organ of Corti and illuminating cochlear mechanics with optical coherence tomography |
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