Mechanical distraction enterogenesis utilizing springs has equal effectiveness in adult and juvenile pigs
Purpose We aim to apply our spring-mediated intestinal lengthening technique to adults and children with short bowel syndrome. We hypothesized that spring-mediated intestinal lengthening would be achieved in adult and juvenile pigs. Methods Adult and juvenile pigs underwent insertion of a compressed...
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| Veröffentlicht in: | Pediatric surgery international 2024-12, Vol.41 (1), p.18 |
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| creator | Rafeeqi, Talha A. Thomas, Anne-Laure Salimi-Jazi, Fereshteh Diyaolu, Modupeola Lopez, Nolan Dunn, James C. Y. |
| description | Purpose
We aim to apply our spring-mediated intestinal lengthening technique to adults and children with short bowel syndrome. We hypothesized that spring-mediated intestinal lengthening would be achieved in adult and juvenile pigs.
Methods
Adult and juvenile pigs underwent insertion of a compressed spring into the jejunum. Jejunum was plicated proximal and distal to the capsule for fixation and control jejunum was marked. Pigs were fed a liquid diet for one week. Spring and control segment lengths were compared using Brown-Forsythe and Welch ANOVA test.
Results
Three adult pigs weighing 30.4 ± 2.1 kg and three juvenile pigs weighing 8.9 ± 1.2 kg underwent spring insertion without complications. Springs were compressed from 7.5 to 2 cm and had an average spring constant of 9.7 ± 1.2 N/m in adults and 5.4 ± 1.5 N/m in juveniles. Springs of 1.3 cm diameter were implanted in adults and springs of 1.0 cm diameter were implanted in juveniles. Spring segments lengthened on average by 86 ± 33% in adults (
p
= 0.04) and 123% in juveniles (
p
|
| doi_str_mv | 10.1007/s00383-024-05923-6 |
| format | Article |
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We aim to apply our spring-mediated intestinal lengthening technique to adults and children with short bowel syndrome. We hypothesized that spring-mediated intestinal lengthening would be achieved in adult and juvenile pigs.
Methods
Adult and juvenile pigs underwent insertion of a compressed spring into the jejunum. Jejunum was plicated proximal and distal to the capsule for fixation and control jejunum was marked. Pigs were fed a liquid diet for one week. Spring and control segment lengths were compared using Brown-Forsythe and Welch ANOVA test.
Results
Three adult pigs weighing 30.4 ± 2.1 kg and three juvenile pigs weighing 8.9 ± 1.2 kg underwent spring insertion without complications. Springs were compressed from 7.5 to 2 cm and had an average spring constant of 9.7 ± 1.2 N/m in adults and 5.4 ± 1.5 N/m in juveniles. Springs of 1.3 cm diameter were implanted in adults and springs of 1.0 cm diameter were implanted in juveniles. Spring segments lengthened on average by 86 ± 33% in adults (
p
= 0.04) and 123% in juveniles (
p
< 0.01) when compared to the initial length. There was no statistically significant difference in lengthening between juvenile and adult pigs (
p
= 0.2).
Conclusion
Intestinal lengthening was feasible in adult pigs but required a higher force for their larger diameter intestine compared to juvenile pigs.</description><identifier>ISSN: 0179-0358</identifier><identifier>ISSN: 1437-9813</identifier><identifier>EISSN: 1437-9813</identifier><identifier>DOI: 10.1007/s00383-024-05923-6</identifier><identifier>PMID: 39625550</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adults ; Age Factors ; Animals ; Disease Models, Animal ; Jejunum - surgery ; Medicine ; Medicine & Public Health ; Minors ; Original Article ; Pediatric Surgery ; Pediatrics ; Short Bowel Syndrome - surgery ; Small intestine ; Surgery ; Swine</subject><ispartof>Pediatric surgery international, 2024-12, Vol.41 (1), p.18</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024 Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><rights>Copyright Springer Nature B.V. Dec 2025</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00383-024-05923-6$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00383-024-05923-6$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,781,785,27929,27930,41493,42562,51324</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39625550$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Rafeeqi, Talha A.</creatorcontrib><creatorcontrib>Thomas, Anne-Laure</creatorcontrib><creatorcontrib>Salimi-Jazi, Fereshteh</creatorcontrib><creatorcontrib>Diyaolu, Modupeola</creatorcontrib><creatorcontrib>Lopez, Nolan</creatorcontrib><creatorcontrib>Dunn, James C. Y.</creatorcontrib><title>Mechanical distraction enterogenesis utilizing springs has equal effectiveness in adult and juvenile pigs</title><title>Pediatric surgery international</title><addtitle>Pediatr Surg Int</addtitle><addtitle>Pediatr Surg Int</addtitle><description>Purpose
We aim to apply our spring-mediated intestinal lengthening technique to adults and children with short bowel syndrome. We hypothesized that spring-mediated intestinal lengthening would be achieved in adult and juvenile pigs.
Methods
Adult and juvenile pigs underwent insertion of a compressed spring into the jejunum. Jejunum was plicated proximal and distal to the capsule for fixation and control jejunum was marked. Pigs were fed a liquid diet for one week. Spring and control segment lengths were compared using Brown-Forsythe and Welch ANOVA test.
Results
Three adult pigs weighing 30.4 ± 2.1 kg and three juvenile pigs weighing 8.9 ± 1.2 kg underwent spring insertion without complications. Springs were compressed from 7.5 to 2 cm and had an average spring constant of 9.7 ± 1.2 N/m in adults and 5.4 ± 1.5 N/m in juveniles. Springs of 1.3 cm diameter were implanted in adults and springs of 1.0 cm diameter were implanted in juveniles. Spring segments lengthened on average by 86 ± 33% in adults (
p
= 0.04) and 123% in juveniles (
p
< 0.01) when compared to the initial length. There was no statistically significant difference in lengthening between juvenile and adult pigs (
p
= 0.2).
Conclusion
Intestinal lengthening was feasible in adult pigs but required a higher force for their larger diameter intestine compared to juvenile pigs.</description><subject>Adults</subject><subject>Age Factors</subject><subject>Animals</subject><subject>Disease Models, Animal</subject><subject>Jejunum - surgery</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Minors</subject><subject>Original Article</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Short Bowel Syndrome - surgery</subject><subject>Small intestine</subject><subject>Surgery</subject><subject>Swine</subject><issn>0179-0358</issn><issn>1437-9813</issn><issn>1437-9813</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkUtLBDEQhIMo7vr4Ax4k4MXLaCeZvI4ivkDxoueQnenZzTKbWSczgv56s64i2JeC5qumqSLkhMEFA9CXCUAYUQAvC5CWi0LtkCkrhS6sYWKXTIFpW4CQZkIOUloCgBHK7pOJsIpLKWFKwhNWCx9D5VtahzT0vhpCFynGAftujhFTSHQcQhs-Q5zTtO6zJLrwieLbmF3YNJg97xs00RCpr8d2oD7WdDnmbWiRrsM8HZG9xrcJj3_0kLze3rxc3xePz3cP11ePxZpxowrGkVtpZakUMKXqyvrGgK51bc0MsOSN13zmN4Ol5jU2JTNeIzLOrGJaHJLz7d11372NmAa3CqnCtvURuzE5wUqwXIIUGT37hy67sY_5u0wJY23JNWTq9IcaZyusXU5g5fsP9xtiBsQW2IaD_d8ZBm5TldtW5XJV7rsqp8QXDUaFDg</recordid><startdate>20241203</startdate><enddate>20241203</enddate><creator>Rafeeqi, Talha A.</creator><creator>Thomas, Anne-Laure</creator><creator>Salimi-Jazi, Fereshteh</creator><creator>Diyaolu, Modupeola</creator><creator>Lopez, Nolan</creator><creator>Dunn, James C. Y.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20241203</creationdate><title>Mechanical distraction enterogenesis utilizing springs has equal effectiveness in adult and juvenile pigs</title><author>Rafeeqi, Talha A. ; Thomas, Anne-Laure ; Salimi-Jazi, Fereshteh ; Diyaolu, Modupeola ; Lopez, Nolan ; Dunn, James C. Y.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1286-12e295954660166dc9af807d7d98b0e42fa72baaaaae472def418a7ee12196173</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adults</topic><topic>Age Factors</topic><topic>Animals</topic><topic>Disease Models, Animal</topic><topic>Jejunum - surgery</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Minors</topic><topic>Original Article</topic><topic>Pediatric Surgery</topic><topic>Pediatrics</topic><topic>Short Bowel Syndrome - surgery</topic><topic>Small intestine</topic><topic>Surgery</topic><topic>Swine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rafeeqi, Talha A.</creatorcontrib><creatorcontrib>Thomas, Anne-Laure</creatorcontrib><creatorcontrib>Salimi-Jazi, Fereshteh</creatorcontrib><creatorcontrib>Diyaolu, Modupeola</creatorcontrib><creatorcontrib>Lopez, Nolan</creatorcontrib><creatorcontrib>Dunn, James C. Y.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatric surgery international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rafeeqi, Talha A.</au><au>Thomas, Anne-Laure</au><au>Salimi-Jazi, Fereshteh</au><au>Diyaolu, Modupeola</au><au>Lopez, Nolan</au><au>Dunn, James C. Y.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mechanical distraction enterogenesis utilizing springs has equal effectiveness in adult and juvenile pigs</atitle><jtitle>Pediatric surgery international</jtitle><stitle>Pediatr Surg Int</stitle><addtitle>Pediatr Surg Int</addtitle><date>2024-12-03</date><risdate>2024</risdate><volume>41</volume><issue>1</issue><spage>18</spage><pages>18-</pages><issn>0179-0358</issn><issn>1437-9813</issn><eissn>1437-9813</eissn><abstract>Purpose
We aim to apply our spring-mediated intestinal lengthening technique to adults and children with short bowel syndrome. We hypothesized that spring-mediated intestinal lengthening would be achieved in adult and juvenile pigs.
Methods
Adult and juvenile pigs underwent insertion of a compressed spring into the jejunum. Jejunum was plicated proximal and distal to the capsule for fixation and control jejunum was marked. Pigs were fed a liquid diet for one week. Spring and control segment lengths were compared using Brown-Forsythe and Welch ANOVA test.
Results
Three adult pigs weighing 30.4 ± 2.1 kg and three juvenile pigs weighing 8.9 ± 1.2 kg underwent spring insertion without complications. Springs were compressed from 7.5 to 2 cm and had an average spring constant of 9.7 ± 1.2 N/m in adults and 5.4 ± 1.5 N/m in juveniles. Springs of 1.3 cm diameter were implanted in adults and springs of 1.0 cm diameter were implanted in juveniles. Spring segments lengthened on average by 86 ± 33% in adults (
p
= 0.04) and 123% in juveniles (
p
< 0.01) when compared to the initial length. There was no statistically significant difference in lengthening between juvenile and adult pigs (
p
= 0.2).
Conclusion
Intestinal lengthening was feasible in adult pigs but required a higher force for their larger diameter intestine compared to juvenile pigs.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>39625550</pmid><doi>10.1007/s00383-024-05923-6</doi></addata></record> |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Adults Age Factors Animals Disease Models, Animal Jejunum - surgery Medicine Medicine & Public Health Minors Original Article Pediatric Surgery Pediatrics Short Bowel Syndrome - surgery Small intestine Surgery Swine |
| title | Mechanical distraction enterogenesis utilizing springs has equal effectiveness in adult and juvenile pigs |
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