Glutamine is critical for the maintenance of type 1 conventional dendritic cells in normal tissue and the tumor microenvironment

Proliferating tumor cells take up glutamine for anabolic processes, engendering glutamine deficiency in the tumor microenvironment. How this might impact immune cells is not well understood. Using multiple mouse models of soft tissue sarcomas, glutamine antagonists, as well as genetic and pharmacolo...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2024-12, Vol.121 (50), p.e2412157121
Hauptverfasser:	Lobel, Graham P, Han, Nanumi, Molina Arocho, William A, Silber, Michal, Shoush, Jason, Noji, Michael C, To, Tsun Ki Jerrick, Zhai, Li, Lesner, Nicholas P, Simon, M Celeste, Haldar, Malay
Format:	Artikel
Sprache:	eng
Schlagworte:	Animal models Animals Antagonists Antigen presentation Cell culture Cell Proliferation Cell survival Dendritic cells Dendritic Cells - immunology Dendritic Cells - metabolism Glutamine Glutamine - metabolism Immune system Mice Mice, Inbred C57BL Rapamycin Signal Transduction Soft tissues TOR protein TOR Serine-Threonine Kinases - metabolism Tumor cells Tumor microenvironment Tumor Microenvironment - immunology Tumors
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