Study on the Clinical Characteristics, Persistent Infection Ability and Viral Load of Human Papillomavirus Type 73 Single Infection
Human papillomavirus (HPV) infection is a main cause of cervical cancer. Different HPV types exhibit significant differences in pathogenicity. Clinical data on HPV73 single infection is limited, this study aimed to analyze the clinical characteristics of HPV73 single infections. We collected cervica...
Gespeichert in:
| Veröffentlicht in: | Journal of medical virology 2024-12, Vol.96 (12), p.e70097 |
|---|---|
| Hauptverfasser: | , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | 12 |
| container_start_page | e70097 |
| container_title | Journal of medical virology |
| container_volume | 96 |
| creator | Chen, Zuyi Nie, Shuangshuang Ran, Jing Wang, Ying Li, Qiongyao Zhao, Hongjuan Chen, Xiaoyan Xiong, Dake Xiao, Daimin |
| description | Human papillomavirus (HPV) infection is a main cause of cervical cancer. Different HPV types exhibit significant differences in pathogenicity. Clinical data on HPV73 single infection is limited, this study aimed to analyze the clinical characteristics of HPV73 single infections. We collected cervical exfoliated cells to examine the infection rate and the clinical characteristics of patients with single HPV73 infection, and to investigate the association of viral load, persistent infection, and pathogenicity. The positive rate of HPV73 among women tested was approximately 0.14% (609/435 072). Among 214 HPV73 single infection cases, the number of patients with normal cytology, cervical intraepithelial neoplasia (CIN)1, CIN2, CIN3, and cervical cancer were 182, 24, 5, 1, and 1, respectively. Follow-up data showed that 14.29% (3/21) of CIN1 patients developed to higher-grade lesions, with 3.73% (5/134) of normal patients progressed to CIN. The viral load in the CIN group was significantly higher than that in the normal group (p = 0.001), and the viral load in the persistent infection group was significantly higher than that of the viral-clearance group (p |
| doi_str_mv | 10.1002/jmv.70097 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_3140923847</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3140923847</sourcerecordid><originalsourceid>FETCH-LOGICAL-p917-45a06a4ba6f7499e545b39f34fc23d6484e978e4401fff43f3b7024454ac41fe3</originalsourceid><addsrcrecordid>eNpNkMFLwzAchYMobk4P_gOSowc70-bXpjmOoU4YONjwWtI2cRlpWpN00LP_uAUnenrv8L3v8BC6jck8JiR5PDTHOSOEszM0jQnPIk5YfP6vT9CV9wdCSM6T5BJNKM8SIASm6Gsb-nrArcVhL_HSaKsrYfByL5yognTaB135B7yRzo9d2oBfrZJV0ONkUWqjw4CFrfG7duNu3Yoatwqv-kZYvBGdNqZtxFG73uPd0EnMKN5q-2Hkn-caXShhvLw55Qztnp92y1W0fnt5XS7WUcdjFkEqSCagFJliwLlMIS0pVxRUldA6gxwkZ7kEILFSCqiiJSMJQAqiglhJOkP3P9rOtZ-99KFotK-kMcLKtvcFjYHwhObARvTuhPZlI-uic7oRbih-f6PfCkxvDA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3140923847</pqid></control><display><type>article</type><title>Study on the Clinical Characteristics, Persistent Infection Ability and Viral Load of Human Papillomavirus Type 73 Single Infection</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Chen, Zuyi ; Nie, Shuangshuang ; Ran, Jing ; Wang, Ying ; Li, Qiongyao ; Zhao, Hongjuan ; Chen, Xiaoyan ; Xiong, Dake ; Xiao, Daimin</creator><creatorcontrib>Chen, Zuyi ; Nie, Shuangshuang ; Ran, Jing ; Wang, Ying ; Li, Qiongyao ; Zhao, Hongjuan ; Chen, Xiaoyan ; Xiong, Dake ; Xiao, Daimin</creatorcontrib><description>Human papillomavirus (HPV) infection is a main cause of cervical cancer. Different HPV types exhibit significant differences in pathogenicity. Clinical data on HPV73 single infection is limited, this study aimed to analyze the clinical characteristics of HPV73 single infections. We collected cervical exfoliated cells to examine the infection rate and the clinical characteristics of patients with single HPV73 infection, and to investigate the association of viral load, persistent infection, and pathogenicity. The positive rate of HPV73 among women tested was approximately 0.14% (609/435 072). Among 214 HPV73 single infection cases, the number of patients with normal cytology, cervical intraepithelial neoplasia (CIN)1, CIN2, CIN3, and cervical cancer were 182, 24, 5, 1, and 1, respectively. Follow-up data showed that 14.29% (3/21) of CIN1 patients developed to higher-grade lesions, with 3.73% (5/134) of normal patients progressed to CIN. The viral load in the CIN group was significantly higher than that in the normal group (p = 0.001), and the viral load in the persistent infection group was significantly higher than that of the viral-clearance group (p < 0.001). HPV73 single infection can lead to cervical cancer, with relatively low pathogenicity. And high viral load is a crucial factor in its persistent infection and pathogenicity.</description><identifier>ISSN: 1096-9071</identifier><identifier>EISSN: 1096-9071</identifier><identifier>DOI: 10.1002/jmv.70097</identifier><identifier>PMID: 39624004</identifier><language>eng</language><publisher>United States</publisher><subject>Adolescent ; Adult ; Aged ; Cervix Uteri - pathology ; Cervix Uteri - virology ; Female ; Human Papillomavirus Viruses ; Humans ; Middle Aged ; Papillomaviridae - classification ; Papillomaviridae - genetics ; Papillomaviridae - isolation & purification ; Papillomaviridae - pathogenicity ; Papillomavirus Infections - virology ; Persistent Infection - virology ; Uterine Cervical Dysplasia - pathology ; Uterine Cervical Dysplasia - virology ; Uterine Cervical Neoplasms - virology ; Viral Load ; Young Adult</subject><ispartof>Journal of medical virology, 2024-12, Vol.96 (12), p.e70097</ispartof><rights>2024 Wiley Periodicals LLC.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-7592-189X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,27928,27929</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39624004$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chen, Zuyi</creatorcontrib><creatorcontrib>Nie, Shuangshuang</creatorcontrib><creatorcontrib>Ran, Jing</creatorcontrib><creatorcontrib>Wang, Ying</creatorcontrib><creatorcontrib>Li, Qiongyao</creatorcontrib><creatorcontrib>Zhao, Hongjuan</creatorcontrib><creatorcontrib>Chen, Xiaoyan</creatorcontrib><creatorcontrib>Xiong, Dake</creatorcontrib><creatorcontrib>Xiao, Daimin</creatorcontrib><title>Study on the Clinical Characteristics, Persistent Infection Ability and Viral Load of Human Papillomavirus Type 73 Single Infection</title><title>Journal of medical virology</title><addtitle>J Med Virol</addtitle><description>Human papillomavirus (HPV) infection is a main cause of cervical cancer. Different HPV types exhibit significant differences in pathogenicity. Clinical data on HPV73 single infection is limited, this study aimed to analyze the clinical characteristics of HPV73 single infections. We collected cervical exfoliated cells to examine the infection rate and the clinical characteristics of patients with single HPV73 infection, and to investigate the association of viral load, persistent infection, and pathogenicity. The positive rate of HPV73 among women tested was approximately 0.14% (609/435 072). Among 214 HPV73 single infection cases, the number of patients with normal cytology, cervical intraepithelial neoplasia (CIN)1, CIN2, CIN3, and cervical cancer were 182, 24, 5, 1, and 1, respectively. Follow-up data showed that 14.29% (3/21) of CIN1 patients developed to higher-grade lesions, with 3.73% (5/134) of normal patients progressed to CIN. The viral load in the CIN group was significantly higher than that in the normal group (p = 0.001), and the viral load in the persistent infection group was significantly higher than that of the viral-clearance group (p < 0.001). HPV73 single infection can lead to cervical cancer, with relatively low pathogenicity. And high viral load is a crucial factor in its persistent infection and pathogenicity.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Cervix Uteri - pathology</subject><subject>Cervix Uteri - virology</subject><subject>Female</subject><subject>Human Papillomavirus Viruses</subject><subject>Humans</subject><subject>Middle Aged</subject><subject>Papillomaviridae - classification</subject><subject>Papillomaviridae - genetics</subject><subject>Papillomaviridae - isolation & purification</subject><subject>Papillomaviridae - pathogenicity</subject><subject>Papillomavirus Infections - virology</subject><subject>Persistent Infection - virology</subject><subject>Uterine Cervical Dysplasia - pathology</subject><subject>Uterine Cervical Dysplasia - virology</subject><subject>Uterine Cervical Neoplasms - virology</subject><subject>Viral Load</subject><subject>Young Adult</subject><issn>1096-9071</issn><issn>1096-9071</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMFLwzAchYMobk4P_gOSowc70-bXpjmOoU4YONjwWtI2cRlpWpN00LP_uAUnenrv8L3v8BC6jck8JiR5PDTHOSOEszM0jQnPIk5YfP6vT9CV9wdCSM6T5BJNKM8SIASm6Gsb-nrArcVhL_HSaKsrYfByL5yognTaB135B7yRzo9d2oBfrZJV0ONkUWqjw4CFrfG7duNu3Yoatwqv-kZYvBGdNqZtxFG73uPd0EnMKN5q-2Hkn-caXShhvLw55Qztnp92y1W0fnt5XS7WUcdjFkEqSCagFJliwLlMIS0pVxRUldA6gxwkZ7kEILFSCqiiJSMJQAqiglhJOkP3P9rOtZ-99KFotK-kMcLKtvcFjYHwhObARvTuhPZlI-uic7oRbih-f6PfCkxvDA</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Chen, Zuyi</creator><creator>Nie, Shuangshuang</creator><creator>Ran, Jing</creator><creator>Wang, Ying</creator><creator>Li, Qiongyao</creator><creator>Zhao, Hongjuan</creator><creator>Chen, Xiaoyan</creator><creator>Xiong, Dake</creator><creator>Xiao, Daimin</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7592-189X</orcidid></search><sort><creationdate>202412</creationdate><title>Study on the Clinical Characteristics, Persistent Infection Ability and Viral Load of Human Papillomavirus Type 73 Single Infection</title><author>Chen, Zuyi ; Nie, Shuangshuang ; Ran, Jing ; Wang, Ying ; Li, Qiongyao ; Zhao, Hongjuan ; Chen, Xiaoyan ; Xiong, Dake ; Xiao, Daimin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p917-45a06a4ba6f7499e545b39f34fc23d6484e978e4401fff43f3b7024454ac41fe3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Cervix Uteri - pathology</topic><topic>Cervix Uteri - virology</topic><topic>Female</topic><topic>Human Papillomavirus Viruses</topic><topic>Humans</topic><topic>Middle Aged</topic><topic>Papillomaviridae - classification</topic><topic>Papillomaviridae - genetics</topic><topic>Papillomaviridae - isolation & purification</topic><topic>Papillomaviridae - pathogenicity</topic><topic>Papillomavirus Infections - virology</topic><topic>Persistent Infection - virology</topic><topic>Uterine Cervical Dysplasia - pathology</topic><topic>Uterine Cervical Dysplasia - virology</topic><topic>Uterine Cervical Neoplasms - virology</topic><topic>Viral Load</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chen, Zuyi</creatorcontrib><creatorcontrib>Nie, Shuangshuang</creatorcontrib><creatorcontrib>Ran, Jing</creatorcontrib><creatorcontrib>Wang, Ying</creatorcontrib><creatorcontrib>Li, Qiongyao</creatorcontrib><creatorcontrib>Zhao, Hongjuan</creatorcontrib><creatorcontrib>Chen, Xiaoyan</creatorcontrib><creatorcontrib>Xiong, Dake</creatorcontrib><creatorcontrib>Xiao, Daimin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical virology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chen, Zuyi</au><au>Nie, Shuangshuang</au><au>Ran, Jing</au><au>Wang, Ying</au><au>Li, Qiongyao</au><au>Zhao, Hongjuan</au><au>Chen, Xiaoyan</au><au>Xiong, Dake</au><au>Xiao, Daimin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Study on the Clinical Characteristics, Persistent Infection Ability and Viral Load of Human Papillomavirus Type 73 Single Infection</atitle><jtitle>Journal of medical virology</jtitle><addtitle>J Med Virol</addtitle><date>2024-12</date><risdate>2024</risdate><volume>96</volume><issue>12</issue><spage>e70097</spage><pages>e70097-</pages><issn>1096-9071</issn><eissn>1096-9071</eissn><abstract>Human papillomavirus (HPV) infection is a main cause of cervical cancer. Different HPV types exhibit significant differences in pathogenicity. Clinical data on HPV73 single infection is limited, this study aimed to analyze the clinical characteristics of HPV73 single infections. We collected cervical exfoliated cells to examine the infection rate and the clinical characteristics of patients with single HPV73 infection, and to investigate the association of viral load, persistent infection, and pathogenicity. The positive rate of HPV73 among women tested was approximately 0.14% (609/435 072). Among 214 HPV73 single infection cases, the number of patients with normal cytology, cervical intraepithelial neoplasia (CIN)1, CIN2, CIN3, and cervical cancer were 182, 24, 5, 1, and 1, respectively. Follow-up data showed that 14.29% (3/21) of CIN1 patients developed to higher-grade lesions, with 3.73% (5/134) of normal patients progressed to CIN. The viral load in the CIN group was significantly higher than that in the normal group (p = 0.001), and the viral load in the persistent infection group was significantly higher than that of the viral-clearance group (p < 0.001). HPV73 single infection can lead to cervical cancer, with relatively low pathogenicity. And high viral load is a crucial factor in its persistent infection and pathogenicity.</abstract><cop>United States</cop><pmid>39624004</pmid><doi>10.1002/jmv.70097</doi><orcidid>https://orcid.org/0000-0001-7592-189X</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1096-9071 |
| ispartof | Journal of medical virology, 2024-12, Vol.96 (12), p.e70097 |
| issn | 1096-9071 1096-9071 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_3140923847 |
| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adolescent Adult Aged Cervix Uteri - pathology Cervix Uteri - virology Female Human Papillomavirus Viruses Humans Middle Aged Papillomaviridae - classification Papillomaviridae - genetics Papillomaviridae - isolation & purification Papillomaviridae - pathogenicity Papillomavirus Infections - virology Persistent Infection - virology Uterine Cervical Dysplasia - pathology Uterine Cervical Dysplasia - virology Uterine Cervical Neoplasms - virology Viral Load Young Adult |
| title | Study on the Clinical Characteristics, Persistent Infection Ability and Viral Load of Human Papillomavirus Type 73 Single Infection |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-17T04%3A59%3A59IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Study%20on%20the%20Clinical%20Characteristics,%20Persistent%20Infection%20Ability%20and%20Viral%20Load%20of%20Human%20Papillomavirus%20Type%2073%20Single%20Infection&rft.jtitle=Journal%20of%20medical%20virology&rft.au=Chen,%20Zuyi&rft.date=2024-12&rft.volume=96&rft.issue=12&rft.spage=e70097&rft.pages=e70097-&rft.issn=1096-9071&rft.eissn=1096-9071&rft_id=info:doi/10.1002/jmv.70097&rft_dat=%3Cproquest_pubme%3E3140923847%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=3140923847&rft_id=info:pmid/39624004&rfr_iscdi=true |