Effect of Meroterpenoids from Sargassum macrocarpum on the Inhibition of Amyloid Polypeptide Aggregation

Amyloid polypeptide aggregation is considered one of the factors involved in the pathogenesis of Alzheimer’s disease (AD) and type 2 diabetes (T2D), and the number of affected patients increases as the population ages. Amyloid β (Aβ) found in the brain of patients with AD and human islet amyloid pol...

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Veröffentlicht in:	Biological & pharmaceutical bulletin 2024/11/30, Vol.47(11), pp.1961-1968
Hauptverfasser:	Tozawa, Yuta, Shinoda, Seiya, Sekiguchi, Mitsuhiro, Miyamae, Yusaku, Shigemori, Hideyuki
Format:	Artikel
Sprache:	eng
Schlagworte:	Alzheimer's disease Amylin Amyloid beta-Peptides - metabolism amyloid β Cytotoxicity Diabetes mellitus (non-insulin dependent) human islet amyloid polypeptide Humans Hydroquinone Intermediates Islet Amyloid Polypeptide - metabolism meroterpenoid Neurodegenerative diseases Oligomers Peptide Fragments - pharmacology Phenolic compounds Polypeptides Protein Aggregates - drug effects Sargassum - chemistry Sargassum macrocarpum Terpenes - isolation & purification Terpenes - pharmacology type 2 diabetes β-Amyloid
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