Reproductive outcomes of high-intensity focused ultrasound ablation and myomectomy for uterine fibroids: a systematic review and meta-analysis

Does high-intensity focused ultrasound (HIFU) ablation have comparable reproductive outcomes to myomectomy for patients with uterine fibroids? A systematic review and a meta-analysis of data extracted from published studies up to March 2024. Through a more structured analysis, HIFU treatment yielded...

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Veröffentlicht in:Reproductive biomedicine online 2025-01, Vol.50 (1), p.104436, Article 104436
Hauptverfasser: Chen, Yishan, Yi, Jingsong, Lin, Shunhe, Xie, Xi, Liu, Xishi, Guo, Sun-Wei
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Yi, Jingsong
Lin, Shunhe
Xie, Xi
Liu, Xishi
Guo, Sun-Wei
description Does high-intensity focused ultrasound (HIFU) ablation have comparable reproductive outcomes to myomectomy for patients with uterine fibroids? A systematic review and a meta-analysis of data extracted from published studies up to March 2024. Through a more structured analysis, HIFU treatment yielded a pooled pregnancy rate of 23.3% (95% CI 11.5 to 37.6%) and a pooled live birth rate (LBR) of 17.3% (95% CI 7.8 to 29.3%), significantly lower than those after myomectomy, which had a pooled pregnancy rate of 56.9% (95% CI 45.6 to 67.9%) and a pooled LBR of 44.1% (95% CI 34.9 to 53.4%) (P = 0.0001 and P = 0.0003, respectively). After controlling for patient age, ultrasound-guided HIFU studies reported significantly lower pregnancy rate and LBR compared with myomectomy. Moreover, studies enrolling younger patients and explicitly recruiting those desiring to conceive reported better reproductive outcomes. Patients with uterine fibroids undergoing HIFU treatment and desiring to preserve their uteri resulted in poorer reproductive outcomes compared with myomectomy. Although uterine fibroids are now the number one disease that receives HIFU treatment worldwide, the overall quality in design and execution of HIFU studies on reproductive outcomes for women with uterine fibroids leaves much room for improvement. Above all, comparative trials against the standard of care are badly needed.
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source ScienceDirect Journals (5 years ago - present)
subjects High-intensity focused ultrasound
Live birth rate
Miscarriage rate
Myomectomy
Pregnancy rate
Uterine fibroids
title Reproductive outcomes of high-intensity focused ultrasound ablation and myomectomy for uterine fibroids: a systematic review and meta-analysis
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