Cardiovascular effects of early maternal separation and escitalopram treatment in rats with depressive-like behaviour
Depression and cardiovascular diseases are two of the world's major health problems. Escitalopram (ESC) is widely used because of its safety in relation to other drugs in that class; however, it can affect the cardiovascular system. The present study evaluated the cardiovascular parameters of d...
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| creator | Veríssimo, Luiz Fernando Alves, Fernando Henrique Ferrari Estrada, Viviane Batista da Costa Marques, Leonardo Andre Andrade, Karoliny Coelho Bonancea, Amanda Monteiro Okano, Natália Tavares Corrêa, Fernando Morgan de Aguiar Pelosi, Gislaine Garcia |
| description | Depression and cardiovascular diseases are two of the world's major health problems. Escitalopram (ESC) is widely used because of its safety in relation to other drugs in that class; however, it can affect the cardiovascular system. The present study evaluated the cardiovascular parameters of depressive-like male rats and the cardiovascular effects of ESC treatment on that condition. The EMS protocol consisted of separating the litter from the dam for 3 h over 13 days. Animals were anesthetized with tribromoethanol (250 mg/kg, intraperitoneally) and the catheters were inserted into the femoral and into the femoral vein. Depressive-like rats showed an increase in the pressor response to phenylephrine (Emax:depressive = 50.36 ± 2.997 mmHg; non-depressive = 39.51 ± 3.328 mmHg; p |
| doi_str_mv | 10.1016/j.autneu.2024.103223 |
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•Early maternal separation induces an increase in cardiovascular response.•Escitalopram treatment reverts the changes caused by maternal separation.•Escitalopram treatment increases parasympathetic modulation.•Escitalopram mechanism facilitates parasympathetic modulation.•Cardiovascular consequences from early maternal separation can be alleviated by escitalopram treatment.</description><identifier>ISSN: 1566-0702</identifier><identifier>ISSN: 1872-7484</identifier><identifier>EISSN: 1872-7484</identifier><identifier>DOI: 10.1016/j.autneu.2024.103223</identifier><identifier>PMID: 39616948</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Animals ; Antidepressive Agents, Second-Generation - pharmacology ; Baroreflex - drug effects ; Baroreflex - physiology ; Blood Pressure - drug effects ; Blood Pressure - physiology ; Cardiovascular safety ; Citalopram - pharmacology ; Depression ; Depression - drug therapy ; Depression - physiopathology ; Depressive-like behaviour ; Disease Models, Animal ; Escitalopram - pharmacology ; Female ; Heart Rate - drug effects ; Male ; Maternal Deprivation ; Phenylephrine - pharmacology ; Rats ; Rats, Wistar ; Selective serotonin reuptake inhibitor</subject><ispartof>Autonomic neuroscience, 2024-12, Vol.256, p.103223, Article 103223</ispartof><rights>2024 Elsevier B.V.</rights><rights>Copyright © 2024 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.autneu.2024.103223$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39616948$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Veríssimo, Luiz Fernando</creatorcontrib><creatorcontrib>Alves, Fernando Henrique Ferrari</creatorcontrib><creatorcontrib>Estrada, Viviane Batista</creatorcontrib><creatorcontrib>da Costa Marques, Leonardo Andre</creatorcontrib><creatorcontrib>Andrade, Karoliny Coelho</creatorcontrib><creatorcontrib>Bonancea, Amanda Monteiro</creatorcontrib><creatorcontrib>Okano, Natália Tavares</creatorcontrib><creatorcontrib>Corrêa, Fernando Morgan de Aguiar</creatorcontrib><creatorcontrib>Pelosi, Gislaine Garcia</creatorcontrib><title>Cardiovascular effects of early maternal separation and escitalopram treatment in rats with depressive-like behaviour</title><title>Autonomic neuroscience</title><addtitle>Auton Neurosci</addtitle><description>Depression and cardiovascular diseases are two of the world's major health problems. Escitalopram (ESC) is widely used because of its safety in relation to other drugs in that class; however, it can affect the cardiovascular system. The present study evaluated the cardiovascular parameters of depressive-like male rats and the cardiovascular effects of ESC treatment on that condition. The EMS protocol consisted of separating the litter from the dam for 3 h over 13 days. Animals were anesthetized with tribromoethanol (250 mg/kg, intraperitoneally) and the catheters were inserted into the femoral and into the femoral vein. Depressive-like rats showed an increase in the pressor response to phenylephrine (Emax:depressive = 50.36 ± 2.997 mmHg; non-depressive = 39.51 ± 3.328 mmHg; p < 0.05) and a reduction in the EC50 (depressive = 0.6203 ± 0.03005 μg/kg; non-depressive = 0.7320 ± 0.03519 μg/kg; p < 0.05) with no change in the other cardiovascular parameters. After treatment with ESC, a reduction of intrinsic heart rate was observed in the depressive-like rats (control: 342 ± 6 bpm; ESC: 316 ± 5 bpm; p < 0.05). In addition, ESC treatment increased the bradycardic (control: −97.81 ± 8.3 bpm; ESC: −137.1 ± 12.31 bpm; p = 0.0236; t = 2.502) during the baroreflex response, caused by an increase in cardiac parasympathetic modulation in the heart, in depressive-like rats (p < 0.001). The findings suggest that depressive-like rats showed cardiovascular changes, and that ESC treatment was able to reverse these changes, suggesting that ESC has a good safety profile for depressive patients with cardiovascular disease due to increased parasympathetic modulation.
•Early maternal separation induces an increase in cardiovascular response.•Escitalopram treatment reverts the changes caused by maternal separation.•Escitalopram treatment increases parasympathetic modulation.•Escitalopram mechanism facilitates parasympathetic modulation.•Cardiovascular consequences from early maternal separation can be alleviated by escitalopram treatment.</description><subject>Animals</subject><subject>Antidepressive Agents, Second-Generation - pharmacology</subject><subject>Baroreflex - drug effects</subject><subject>Baroreflex - physiology</subject><subject>Blood Pressure - drug effects</subject><subject>Blood Pressure - physiology</subject><subject>Cardiovascular safety</subject><subject>Citalopram - pharmacology</subject><subject>Depression</subject><subject>Depression - drug therapy</subject><subject>Depression - physiopathology</subject><subject>Depressive-like behaviour</subject><subject>Disease Models, Animal</subject><subject>Escitalopram - pharmacology</subject><subject>Female</subject><subject>Heart Rate - drug effects</subject><subject>Male</subject><subject>Maternal Deprivation</subject><subject>Phenylephrine - pharmacology</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Selective serotonin reuptake inhibitor</subject><issn>1566-0702</issn><issn>1872-7484</issn><issn>1872-7484</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kcuKGzEQRUVIiD2PPwhBy2zaKUltWb0JBDOPwMBsJmtR3SoxcvoVSe0wfx8ZexaiRHEoqu5h7IuAjQChvx82uOSRlo0EWZeWklJ9YGthdrLa1ab-WP5brSvYgVyxq5QOAGCg0Z_ZSjVa6KY2a7bsMbowHTF1S4-Rk_fU5cQnzwlj_8YHzBRH7HmiGSPmMI0cR8cpdSFjP80RB54jYR5ozDyMvECJ_wv5lTuaI6UUjlT14Q_xll7xGKYl3rBPHvtEt5d6zX7f373sH6un54df-59PFYlG58o5MlAug84gSW28aXbGSdkCaOmlRMLWew1agRCyPL8lraTqdNe2TrTqmn07z53j9HehlO0QUkd9jyNNS7JK1GAaJYws6NcLurQDOTvHMGB8s-9RFeDHGaCy8DFQtCUBGjtyIZbIrJuCFWBPbuzBnt3Ykxt7dqP-A2t-hOY</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Veríssimo, Luiz Fernando</creator><creator>Alves, Fernando Henrique Ferrari</creator><creator>Estrada, Viviane Batista</creator><creator>da Costa Marques, Leonardo Andre</creator><creator>Andrade, Karoliny Coelho</creator><creator>Bonancea, Amanda Monteiro</creator><creator>Okano, Natália Tavares</creator><creator>Corrêa, Fernando Morgan de Aguiar</creator><creator>Pelosi, Gislaine Garcia</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>202412</creationdate><title>Cardiovascular effects of early maternal separation and escitalopram treatment in rats with depressive-like behaviour</title><author>Veríssimo, Luiz Fernando ; Alves, Fernando Henrique Ferrari ; Estrada, Viviane Batista ; da Costa Marques, Leonardo Andre ; Andrade, Karoliny Coelho ; Bonancea, Amanda Monteiro ; Okano, Natália Tavares ; Corrêa, Fernando Morgan de Aguiar ; Pelosi, Gislaine Garcia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-e196t-dde801030c8ae268f8978d22b0062f22aeabff60630112011f5e6323c6cbbd1b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Antidepressive Agents, Second-Generation - pharmacology</topic><topic>Baroreflex - drug effects</topic><topic>Baroreflex - physiology</topic><topic>Blood Pressure - drug effects</topic><topic>Blood Pressure - physiology</topic><topic>Cardiovascular safety</topic><topic>Citalopram - pharmacology</topic><topic>Depression</topic><topic>Depression - drug therapy</topic><topic>Depression - physiopathology</topic><topic>Depressive-like behaviour</topic><topic>Disease Models, Animal</topic><topic>Escitalopram - pharmacology</topic><topic>Female</topic><topic>Heart Rate - drug effects</topic><topic>Male</topic><topic>Maternal Deprivation</topic><topic>Phenylephrine - pharmacology</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Selective serotonin reuptake inhibitor</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Veríssimo, Luiz Fernando</creatorcontrib><creatorcontrib>Alves, Fernando Henrique Ferrari</creatorcontrib><creatorcontrib>Estrada, Viviane Batista</creatorcontrib><creatorcontrib>da Costa Marques, Leonardo Andre</creatorcontrib><creatorcontrib>Andrade, Karoliny Coelho</creatorcontrib><creatorcontrib>Bonancea, Amanda Monteiro</creatorcontrib><creatorcontrib>Okano, Natália Tavares</creatorcontrib><creatorcontrib>Corrêa, Fernando Morgan de Aguiar</creatorcontrib><creatorcontrib>Pelosi, Gislaine Garcia</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Autonomic neuroscience</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Veríssimo, Luiz Fernando</au><au>Alves, Fernando Henrique Ferrari</au><au>Estrada, Viviane Batista</au><au>da Costa Marques, Leonardo Andre</au><au>Andrade, Karoliny Coelho</au><au>Bonancea, Amanda Monteiro</au><au>Okano, Natália Tavares</au><au>Corrêa, Fernando Morgan de Aguiar</au><au>Pelosi, Gislaine Garcia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cardiovascular effects of early maternal separation and escitalopram treatment in rats with depressive-like behaviour</atitle><jtitle>Autonomic neuroscience</jtitle><addtitle>Auton Neurosci</addtitle><date>2024-12</date><risdate>2024</risdate><volume>256</volume><spage>103223</spage><pages>103223-</pages><artnum>103223</artnum><issn>1566-0702</issn><issn>1872-7484</issn><eissn>1872-7484</eissn><abstract>Depression and cardiovascular diseases are two of the world's major health problems. Escitalopram (ESC) is widely used because of its safety in relation to other drugs in that class; however, it can affect the cardiovascular system. The present study evaluated the cardiovascular parameters of depressive-like male rats and the cardiovascular effects of ESC treatment on that condition. The EMS protocol consisted of separating the litter from the dam for 3 h over 13 days. Animals were anesthetized with tribromoethanol (250 mg/kg, intraperitoneally) and the catheters were inserted into the femoral and into the femoral vein. Depressive-like rats showed an increase in the pressor response to phenylephrine (Emax:depressive = 50.36 ± 2.997 mmHg; non-depressive = 39.51 ± 3.328 mmHg; p < 0.05) and a reduction in the EC50 (depressive = 0.6203 ± 0.03005 μg/kg; non-depressive = 0.7320 ± 0.03519 μg/kg; p < 0.05) with no change in the other cardiovascular parameters. After treatment with ESC, a reduction of intrinsic heart rate was observed in the depressive-like rats (control: 342 ± 6 bpm; ESC: 316 ± 5 bpm; p < 0.05). In addition, ESC treatment increased the bradycardic (control: −97.81 ± 8.3 bpm; ESC: −137.1 ± 12.31 bpm; p = 0.0236; t = 2.502) during the baroreflex response, caused by an increase in cardiac parasympathetic modulation in the heart, in depressive-like rats (p < 0.001). The findings suggest that depressive-like rats showed cardiovascular changes, and that ESC treatment was able to reverse these changes, suggesting that ESC has a good safety profile for depressive patients with cardiovascular disease due to increased parasympathetic modulation.
•Early maternal separation induces an increase in cardiovascular response.•Escitalopram treatment reverts the changes caused by maternal separation.•Escitalopram treatment increases parasympathetic modulation.•Escitalopram mechanism facilitates parasympathetic modulation.•Cardiovascular consequences from early maternal separation can be alleviated by escitalopram treatment.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>39616948</pmid><doi>10.1016/j.autneu.2024.103223</doi></addata></record> |
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| subjects | Animals Antidepressive Agents, Second-Generation - pharmacology Baroreflex - drug effects Baroreflex - physiology Blood Pressure - drug effects Blood Pressure - physiology Cardiovascular safety Citalopram - pharmacology Depression Depression - drug therapy Depression - physiopathology Depressive-like behaviour Disease Models, Animal Escitalopram - pharmacology Female Heart Rate - drug effects Male Maternal Deprivation Phenylephrine - pharmacology Rats Rats, Wistar Selective serotonin reuptake inhibitor |
| title | Cardiovascular effects of early maternal separation and escitalopram treatment in rats with depressive-like behaviour |
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