Hydroxypropyl β cyclodextrins effects on self-assembly of cyclic peptide, lanreotide acetate, in water and subsequent release rate from an in vitro emulator of subcutaneous delivery

Most of the peptide drugs are often delivered subcutaneously. The significant barrier in this type of peptide administration is the high concentration of formulation, which can lead to self-assembly and aggregation. These phenomena can negatively impact the peptide drug's bioavailability, manuf...

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Veröffentlicht in:	Journal of pharmaceutical sciences 2024-11
Hauptverfasser:	Jafari, Negar, Addison, Camille, Lou, Hao, Hageman, Michael J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Biopharmaceutical characterization Complexation Controlled release Cyclodextrin(s) Diffusion Drug excipient interactions Peptide delivery Peptide(s) Subcutaneous drug delivery Viscosity
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