Spinal cord blood flow elevation with systemic vasopressor noradrenaline is partly mediated by vasodilation of spinal arteries due to reduced expression of alpha adrenoreceptors

Elevation of mean arterial blood pressure (MAP) has been proposed to raise spinal cord blood flow (SCBF) after traumatic spinal cord injury (TSCI). Current clinical guidelines for cervical TSCI suggest maintaining MAP 85–90 mmHg for 5–7 days using vasopressors, eg, noradrenaline. However, it remains...

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Veröffentlicht in:	The spine journal 2024-11
Hauptverfasser:	Entezari, Seyar, Thygesen, Mathias Møller, Staehr, Christian, Melnikova, Elizaveta, Skov, Mathias, Rajanathan, Rajkumar, Rasmussen, Mads, Rasmussen, Mikkel Mylius, Matchkov, Vladimir V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic receptors Noradrenaline Pigs Spinal cord blood flow Vasodilation Vasopressor
Online-Zugang:	Volltext
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