Development and validation of a controlled heating apparatus for long‐term MRI of 3D microfluidic tumor models

Conventional testing of novel contrast agents for magnetic resonance imaging (MRI) involves cell and animal studies. However, 2D cultures lack dynamic flow and in vivo MRI is limited by regulatory approval of long‐term anesthesia use. Microfluidic tumor models (MTMs) offer a cost‐effective, reproduc...

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Veröffentlicht in:	AIChE journal 2024-12, Vol.70 (12), p.n/a
Hauptverfasser:	Alkhadrawi, Hassan, Dese, Kokeb, Panchal, Dhruvi M., Pueschel, Alexander R., Freshwater, Kasey A., Stewart, Amanda, Henderson, Haleigh, Elkins, Michael, Dave, Raj T., Wilson, Hunter, Bennewitz, John W., Bennewitz, Margaret F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia Animal models Cell culture Contrast agents Contrast media Control equipment Field strength Heating In vivo methods and tests Magnetic resonance imaging Manganese microfluidic device Microfluidic devices Microfluidics MRI screening Surface temperature temperature Tumor cells Tumors Two dimensional flow
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