CTX-1 and TRACP-5b as biomarkers for osteoporosis risk in type 2 diabetes mellitus: a cross-sectional study
Objective Type 2 diabetes mellitus (T2DM) demonstrates a higher risk of fractures compared to the healthy population. Therefore, the aim of our study is to assess the risk of osteoporosis in T2DM patients. Methodology A cross-sectional observational study was conducted in T2DM patients. The serum le...
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| Veröffentlicht in: | Journal of diabetes and metabolic disorders 2024-07, Vol.23 (2), p.2055-2064 |
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| container_issue | 2 |
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| container_title | Journal of diabetes and metabolic disorders |
| container_volume | 23 |
| creator | Roy, Madhura Majid, Haya Khan, Parvej Sharma, Nikhil Kohli, Sunil Islam, Sajad Ul Vohora, Divya Nidhi |
| description | Objective
Type 2 diabetes mellitus (T2DM) demonstrates a higher risk of fractures compared to the healthy population. Therefore, the aim of our study is to assess the risk of osteoporosis in T2DM patients.
Methodology
A cross-sectional observational study was conducted in T2DM patients. The serum levels of bone resorption markers- carboxy-terminal crosslinked telopeptide of type 1 collagen (CTX-1) and tartrate-resistant acid phosphatase 5b (TRACP-5b) were compared in the T2DM group (
n
= 43) and the control group (
n
= 43) and its association with duration of T2DM, HbA1c level, body mass index (BMI), oral hypoglycaemic agents (OHA), and level of functioning was evaluated.
Results
CTX-1 and TRACP-5b were significantly lower in the T2DM group compared to the control group (
p
|
| doi_str_mv | 10.1007/s40200-024-01464-w |
| format | Article |
| fullrecord | <record><control><sourceid>gale_proqu</sourceid><recordid>TN_cdi_proquest_miscellaneous_3134068238</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A801052086</galeid><sourcerecordid>A801052086</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-d5069ba2487e9bf7f9c27c7594da9c792c52db6336796e09d0d4a5a8f972f39d3</originalsourceid><addsrcrecordid>eNp9kV1rHCEUhofS0IQ0f6AXRSiU3pj6MaNj75alXxBoCBvonTjqJGZnxq3HIey_r5tJSwKleqEcn_fged-qekPJOSVEfoSaMEIwYTUmtBY1vn9RnTDWUCyalr58cj-uzgDuSFlSti0Vr6pjrgQljWAn1Xa9-YkpMpNDm6vV-hI3HTKAuhBHk7Y-AepjQhGyj7uYIgRAKcAWhQnl_c4jhlwwnc8e0OiHIeQZPiGDbEEBg7c5xMkMCPLs9q-ro94M4M8ez9Pq-svnzfobvvjx9ft6dYEtZyJj1xChOsPqVnrV9bJXlkkrG1U7o6xUzDbMdYJzIZXwRDniatOYtleS9Vw5flp9WPruUvw1e8h6DGDL78zk4wyaU14T0TLeFvTdgt6Ywesw9TEnYw-4XrWkeMRIKwp1_g-qbOfHYOPk-1DqzwTvnwhuvRnyLcRhPrgBz0G2gA-GJd_rXQrF-b2mRB9y1kvOuuSsH3LW90X09nG-uRu9-yv5k2oB-AJAeZpufNJ3cU4lB_hf29-cWbAD</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3134068238</pqid></control><display><type>article</type><title>CTX-1 and TRACP-5b as biomarkers for osteoporosis risk in type 2 diabetes mellitus: a cross-sectional study</title><source>Springer Nature - Complete Springer Journals</source><creator>Roy, Madhura ; Majid, Haya ; Khan, Parvej ; Sharma, Nikhil ; Kohli, Sunil ; Islam, Sajad Ul ; Vohora, Divya ; Nidhi</creator><creatorcontrib>Roy, Madhura ; Majid, Haya ; Khan, Parvej ; Sharma, Nikhil ; Kohli, Sunil ; Islam, Sajad Ul ; Vohora, Divya ; Nidhi</creatorcontrib><description>Objective
Type 2 diabetes mellitus (T2DM) demonstrates a higher risk of fractures compared to the healthy population. Therefore, the aim of our study is to assess the risk of osteoporosis in T2DM patients.
Methodology
A cross-sectional observational study was conducted in T2DM patients. The serum levels of bone resorption markers- carboxy-terminal crosslinked telopeptide of type 1 collagen (CTX-1) and tartrate-resistant acid phosphatase 5b (TRACP-5b) were compared in the T2DM group (
n
= 43) and the control group (
n
= 43) and its association with duration of T2DM, HbA1c level, body mass index (BMI), oral hypoglycaemic agents (OHA), and level of functioning was evaluated.
Results
CTX-1 and TRACP-5b were significantly lower in the T2DM group compared to the control group (
p
< 0.05). There was no significant correlation between the bone resorption markers and the duration of T2DM and HbA1c levels. However, a significant positive correlation was found between the level of functioning and TRACP-5b level, but no such correlation was observed in T2DM patients. The linear regression model revealed that none of the OHA affected the levels of CTX-1 and TRACP-5b.
Conclusion
The bone resorption markers are not influenced by the duration of T2DM and HbA1c level. However, they were significantly associated with BMI and the level of functionality. However, further research is needed to strengthen the evidence of the association between T2DM and osteoporosis.</description><identifier>ISSN: 2251-6581</identifier><identifier>EISSN: 2251-6581</identifier><identifier>DOI: 10.1007/s40200-024-01464-w</identifier><identifier>PMID: 39610562</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Body mass index ; Collagen ; Comparative analysis ; Diabetes ; Endocrinology ; Glycosylated hemoglobin ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Metabolic Diseases ; Osteoporosis ; Phosphatases ; Research Article ; Risk factors ; Type 2 diabetes</subject><ispartof>Journal of diabetes and metabolic disorders, 2024-07, Vol.23 (2), p.2055-2064</ispartof><rights>The Author(s), under exclusive licence to Tehran University of Medical Sciences 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>COPYRIGHT 2024 BioMed Central Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-d5069ba2487e9bf7f9c27c7594da9c792c52db6336796e09d0d4a5a8f972f39d3</cites><orcidid>0000-0002-2509-3026</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s40200-024-01464-w$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s40200-024-01464-w$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,778,782,27911,27912,41475,42544,51306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39610562$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Roy, Madhura</creatorcontrib><creatorcontrib>Majid, Haya</creatorcontrib><creatorcontrib>Khan, Parvej</creatorcontrib><creatorcontrib>Sharma, Nikhil</creatorcontrib><creatorcontrib>Kohli, Sunil</creatorcontrib><creatorcontrib>Islam, Sajad Ul</creatorcontrib><creatorcontrib>Vohora, Divya</creatorcontrib><creatorcontrib>Nidhi</creatorcontrib><title>CTX-1 and TRACP-5b as biomarkers for osteoporosis risk in type 2 diabetes mellitus: a cross-sectional study</title><title>Journal of diabetes and metabolic disorders</title><addtitle>J Diabetes Metab Disord</addtitle><addtitle>J Diabetes Metab Disord</addtitle><description>Objective
Type 2 diabetes mellitus (T2DM) demonstrates a higher risk of fractures compared to the healthy population. Therefore, the aim of our study is to assess the risk of osteoporosis in T2DM patients.
Methodology
A cross-sectional observational study was conducted in T2DM patients. The serum levels of bone resorption markers- carboxy-terminal crosslinked telopeptide of type 1 collagen (CTX-1) and tartrate-resistant acid phosphatase 5b (TRACP-5b) were compared in the T2DM group (
n
= 43) and the control group (
n
= 43) and its association with duration of T2DM, HbA1c level, body mass index (BMI), oral hypoglycaemic agents (OHA), and level of functioning was evaluated.
Results
CTX-1 and TRACP-5b were significantly lower in the T2DM group compared to the control group (
p
< 0.05). There was no significant correlation between the bone resorption markers and the duration of T2DM and HbA1c levels. However, a significant positive correlation was found between the level of functioning and TRACP-5b level, but no such correlation was observed in T2DM patients. The linear regression model revealed that none of the OHA affected the levels of CTX-1 and TRACP-5b.
Conclusion
The bone resorption markers are not influenced by the duration of T2DM and HbA1c level. However, they were significantly associated with BMI and the level of functionality. However, further research is needed to strengthen the evidence of the association between T2DM and osteoporosis.</description><subject>Body mass index</subject><subject>Collagen</subject><subject>Comparative analysis</subject><subject>Diabetes</subject><subject>Endocrinology</subject><subject>Glycosylated hemoglobin</subject><subject>Medical research</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Medicine, Experimental</subject><subject>Metabolic Diseases</subject><subject>Osteoporosis</subject><subject>Phosphatases</subject><subject>Research Article</subject><subject>Risk factors</subject><subject>Type 2 diabetes</subject><issn>2251-6581</issn><issn>2251-6581</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kV1rHCEUhofS0IQ0f6AXRSiU3pj6MaNj75alXxBoCBvonTjqJGZnxq3HIey_r5tJSwKleqEcn_fged-qekPJOSVEfoSaMEIwYTUmtBY1vn9RnTDWUCyalr58cj-uzgDuSFlSti0Vr6pjrgQljWAn1Xa9-YkpMpNDm6vV-hI3HTKAuhBHk7Y-AepjQhGyj7uYIgRAKcAWhQnl_c4jhlwwnc8e0OiHIeQZPiGDbEEBg7c5xMkMCPLs9q-ro94M4M8ez9Pq-svnzfobvvjx9ft6dYEtZyJj1xChOsPqVnrV9bJXlkkrG1U7o6xUzDbMdYJzIZXwRDniatOYtleS9Vw5flp9WPruUvw1e8h6DGDL78zk4wyaU14T0TLeFvTdgt6Ywesw9TEnYw-4XrWkeMRIKwp1_g-qbOfHYOPk-1DqzwTvnwhuvRnyLcRhPrgBz0G2gA-GJd_rXQrF-b2mRB9y1kvOuuSsH3LW90X09nG-uRu9-yv5k2oB-AJAeZpufNJ3cU4lB_hf29-cWbAD</recordid><startdate>20240712</startdate><enddate>20240712</enddate><creator>Roy, Madhura</creator><creator>Majid, Haya</creator><creator>Khan, Parvej</creator><creator>Sharma, Nikhil</creator><creator>Kohli, Sunil</creator><creator>Islam, Sajad Ul</creator><creator>Vohora, Divya</creator><creator>Nidhi</creator><general>Springer International Publishing</general><general>BioMed Central Ltd</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-2509-3026</orcidid></search><sort><creationdate>20240712</creationdate><title>CTX-1 and TRACP-5b as biomarkers for osteoporosis risk in type 2 diabetes mellitus: a cross-sectional study</title><author>Roy, Madhura ; Majid, Haya ; Khan, Parvej ; Sharma, Nikhil ; Kohli, Sunil ; Islam, Sajad Ul ; Vohora, Divya ; Nidhi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-d5069ba2487e9bf7f9c27c7594da9c792c52db6336796e09d0d4a5a8f972f39d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Body mass index</topic><topic>Collagen</topic><topic>Comparative analysis</topic><topic>Diabetes</topic><topic>Endocrinology</topic><topic>Glycosylated hemoglobin</topic><topic>Medical research</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Medicine, Experimental</topic><topic>Metabolic Diseases</topic><topic>Osteoporosis</topic><topic>Phosphatases</topic><topic>Research Article</topic><topic>Risk factors</topic><topic>Type 2 diabetes</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Roy, Madhura</creatorcontrib><creatorcontrib>Majid, Haya</creatorcontrib><creatorcontrib>Khan, Parvej</creatorcontrib><creatorcontrib>Sharma, Nikhil</creatorcontrib><creatorcontrib>Kohli, Sunil</creatorcontrib><creatorcontrib>Islam, Sajad Ul</creatorcontrib><creatorcontrib>Vohora, Divya</creatorcontrib><creatorcontrib>Nidhi</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of diabetes and metabolic disorders</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Roy, Madhura</au><au>Majid, Haya</au><au>Khan, Parvej</au><au>Sharma, Nikhil</au><au>Kohli, Sunil</au><au>Islam, Sajad Ul</au><au>Vohora, Divya</au><au>Nidhi</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>CTX-1 and TRACP-5b as biomarkers for osteoporosis risk in type 2 diabetes mellitus: a cross-sectional study</atitle><jtitle>Journal of diabetes and metabolic disorders</jtitle><stitle>J Diabetes Metab Disord</stitle><addtitle>J Diabetes Metab Disord</addtitle><date>2024-07-12</date><risdate>2024</risdate><volume>23</volume><issue>2</issue><spage>2055</spage><epage>2064</epage><pages>2055-2064</pages><issn>2251-6581</issn><eissn>2251-6581</eissn><abstract>Objective
Type 2 diabetes mellitus (T2DM) demonstrates a higher risk of fractures compared to the healthy population. Therefore, the aim of our study is to assess the risk of osteoporosis in T2DM patients.
Methodology
A cross-sectional observational study was conducted in T2DM patients. The serum levels of bone resorption markers- carboxy-terminal crosslinked telopeptide of type 1 collagen (CTX-1) and tartrate-resistant acid phosphatase 5b (TRACP-5b) were compared in the T2DM group (
n
= 43) and the control group (
n
= 43) and its association with duration of T2DM, HbA1c level, body mass index (BMI), oral hypoglycaemic agents (OHA), and level of functioning was evaluated.
Results
CTX-1 and TRACP-5b were significantly lower in the T2DM group compared to the control group (
p
< 0.05). There was no significant correlation between the bone resorption markers and the duration of T2DM and HbA1c levels. However, a significant positive correlation was found between the level of functioning and TRACP-5b level, but no such correlation was observed in T2DM patients. The linear regression model revealed that none of the OHA affected the levels of CTX-1 and TRACP-5b.
Conclusion
The bone resorption markers are not influenced by the duration of T2DM and HbA1c level. However, they were significantly associated with BMI and the level of functionality. However, further research is needed to strengthen the evidence of the association between T2DM and osteoporosis.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>39610562</pmid><doi>10.1007/s40200-024-01464-w</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0002-2509-3026</orcidid></addata></record> |
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| source | Springer Nature - Complete Springer Journals |
| subjects | Body mass index Collagen Comparative analysis Diabetes Endocrinology Glycosylated hemoglobin Medical research Medicine Medicine & Public Health Medicine, Experimental Metabolic Diseases Osteoporosis Phosphatases Research Article Risk factors Type 2 diabetes |
| title | CTX-1 and TRACP-5b as biomarkers for osteoporosis risk in type 2 diabetes mellitus: a cross-sectional study |
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