Sarcomas arising in MEN1 patients: demonstrating LOH of the MEN1 locus and loss of menin expression

Multiple endocrine neoplasia type 1 (MEN1) is a hereditary tumor syndrome characterized by endocrine tumors, typically from parathyroid, pancreatic, or anterior pituitary origin. In addition, benign cutaneous soft tissue tumors are prevalent in MEN1 patients. Although sarcomas have been reported in...

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Veröffentlicht in:	Familial cancer 2025-03, Vol.24 (1), p.10, Article 10
Hauptverfasser:	van Leeuwaarde, Rachel S., Halfdanarson, Thorvardur R., Sudhakar, Shwetha M., Meijers, Ruud W. J., Folpe, Andrew L., Brosens, Lodewijk A. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Biomedical and Life Sciences Biomedicine Cancer Cancer Research Chromosomes Dopamine Epidemiology Female Heterozygosity Human Genetics Humans Immunohistochemistry Loss of Heterozygosity Male Medical history Middle Aged Multiple endocrine neoplasia Multiple Endocrine Neoplasia Type 1 - genetics Mutation Neuroendocrine tumors Oncology Original Article Pathology Patients Pituitary (anterior) Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins - metabolism Rhabdomyosarcoma Sarcoma Sarcoma - genetics Surgery Tumors
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