Influencing factors and effects of low oocyte retrieval in patients with polycystic ovary syndrome undergoing in-vitro fertilization
•E2 level/follicle (≥12 mm) on the trigger day could predict low oocyte retrieval events in patients with PCOS.•Low oocyte retrieval may not affect oocyte and embryo developmental potential.•Low oocyte retrieval may increase the risk of no embryo available for transfer. To investigate influencing fa...
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| Veröffentlicht in: | European journal of obstetrics & gynecology and reproductive biology 2025-01, Vol.304, p.97-103 |
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| creator | Yin, Huiqun Zhu, Jie Wang, Cunli Luan, Kang Wu, Yan Ni, Feng |
| description | •E2 level/follicle (≥12 mm) on the trigger day could predict low oocyte retrieval events in patients with PCOS.•Low oocyte retrieval may not affect oocyte and embryo developmental potential.•Low oocyte retrieval may increase the risk of no embryo available for transfer.
To investigate influencing factors and effects of low oocyte retrieval in patients with polycystic ovary syndrome (PCOS) undergoing in-vitro fertilization (IVF).
In total, 720 patients with PCOS undergoing IVF were enrolled in this retrospective study from January 2017 to December 2022. The oocyte retrieval rate (ORR) was defined as the ratio of the number of oocytes retrieved to the number of follicles ≥ 12 mm in diameter on the trigger day. Using 1 standard deviation from the mean ORR as the boundary value, patients were divided into low and normal ORR groups. Patient characteristics, stimulation protocols, serum hormone levels, oocyte maturity, embryo developmental quality, and pregnancy outcomes of fresh transfer cycles were analysed.
ORR ranged from 0.06 to 2.69, with a mean value of 1.02. Compared with the normal ORR group (ORR ≥ 0.65), patients in the low ORR group (ORR |
| doi_str_mv | 10.1016/j.ejogrb.2024.11.028 |
| format | Article |
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To investigate influencing factors and effects of low oocyte retrieval in patients with polycystic ovary syndrome (PCOS) undergoing in-vitro fertilization (IVF).
In total, 720 patients with PCOS undergoing IVF were enrolled in this retrospective study from January 2017 to December 2022. The oocyte retrieval rate (ORR) was defined as the ratio of the number of oocytes retrieved to the number of follicles ≥ 12 mm in diameter on the trigger day. Using 1 standard deviation from the mean ORR as the boundary value, patients were divided into low and normal ORR groups. Patient characteristics, stimulation protocols, serum hormone levels, oocyte maturity, embryo developmental quality, and pregnancy outcomes of fresh transfer cycles were analysed.
ORR ranged from 0.06 to 2.69, with a mean value of 1.02. Compared with the normal ORR group (ORR ≥ 0.65), patients in the low ORR group (ORR < 0.65) had a higher body mass index; higher antral follicle count (AFC); more days of gonadotrophin stimulation; and lower serum oestradiol (E2) level, lower progesterone level and lower E2 level/follicle (≥12 mm) on the trigger day. Multivariate logistic regression analysis showed AFC [adjusted odds ratio (aOR) 1.05, 95 % confidence interval (CI) 1.0120–1.0940], E2 level/follicle (≥12 mm) (aOR 0.99, 95 % CI 0.9888–0.9972) and progesterone level (aOR 0.41, 95 % CI 0.2402–0.6649) on the trigger day were significantly associated with low ORR. Receiver operator characteristic curve analyses revealed that serum E2 level/follicle (≥12 mm) had an area under the curve of 0.7036 (95 % CI 0.65–0.76; p < 0.01). The cut-off value was 169.2 pg/ml, with sensitivity of 65 % and specificity of 65 %, for predicting low ORR. Low ORR was associated with fewer top-quality embryos and more cycles with no embryos available for transfer. The rates of metaphase II oocytes, top-quality embryos, clinical pregnancy and live birth did not differ between the two groups.
Serum E2 level/follicle (≥12 mm) on the trigger day may be used as a predictive factor for low ORR in patients with PCOS. Low ORR may not affect oocyte and embryo developmental potential under appropriate ovarian stimulation management, but likely increases the risk of no embryos being available for transfer.</description><identifier>ISSN: 0301-2115</identifier><identifier>ISSN: 1872-7654</identifier><identifier>EISSN: 1872-7654</identifier><identifier>DOI: 10.1016/j.ejogrb.2024.11.028</identifier><identifier>PMID: 39608208</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Adult ; Estradiol - blood ; Female ; Fertilization in Vitro - methods ; Humans ; In-vitro fertilization ; Infertility, Female - blood ; Infertility, Female - etiology ; Infertility, Female - therapy ; Oocyte Retrieval ; Ovulation Induction - methods ; Polycystic ovary syndrome ; Polycystic Ovary Syndrome - blood ; Polycystic Ovary Syndrome - complications ; Polycystic Ovary Syndrome - therapy ; Pregnancy ; Pregnancy outcome ; Pregnancy Rate ; Retrospective Studies</subject><ispartof>European journal of obstetrics & gynecology and reproductive biology, 2025-01, Vol.304, p.97-103</ispartof><rights>2024</rights><rights>Copyright © 2024. Published by Elsevier B.V.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c241t-51b681a2b5053ed92dfee11161be3c9b9a96432711f0fceb97fa36da2cd746743</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0301211524006353$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39608208$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yin, Huiqun</creatorcontrib><creatorcontrib>Zhu, Jie</creatorcontrib><creatorcontrib>Wang, Cunli</creatorcontrib><creatorcontrib>Luan, Kang</creatorcontrib><creatorcontrib>Wu, Yan</creatorcontrib><creatorcontrib>Ni, Feng</creatorcontrib><title>Influencing factors and effects of low oocyte retrieval in patients with polycystic ovary syndrome undergoing in-vitro fertilization</title><title>European journal of obstetrics & gynecology and reproductive biology</title><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><description>•E2 level/follicle (≥12 mm) on the trigger day could predict low oocyte retrieval events in patients with PCOS.•Low oocyte retrieval may not affect oocyte and embryo developmental potential.•Low oocyte retrieval may increase the risk of no embryo available for transfer.
To investigate influencing factors and effects of low oocyte retrieval in patients with polycystic ovary syndrome (PCOS) undergoing in-vitro fertilization (IVF).
In total, 720 patients with PCOS undergoing IVF were enrolled in this retrospective study from January 2017 to December 2022. The oocyte retrieval rate (ORR) was defined as the ratio of the number of oocytes retrieved to the number of follicles ≥ 12 mm in diameter on the trigger day. Using 1 standard deviation from the mean ORR as the boundary value, patients were divided into low and normal ORR groups. Patient characteristics, stimulation protocols, serum hormone levels, oocyte maturity, embryo developmental quality, and pregnancy outcomes of fresh transfer cycles were analysed.
ORR ranged from 0.06 to 2.69, with a mean value of 1.02. Compared with the normal ORR group (ORR ≥ 0.65), patients in the low ORR group (ORR < 0.65) had a higher body mass index; higher antral follicle count (AFC); more days of gonadotrophin stimulation; and lower serum oestradiol (E2) level, lower progesterone level and lower E2 level/follicle (≥12 mm) on the trigger day. Multivariate logistic regression analysis showed AFC [adjusted odds ratio (aOR) 1.05, 95 % confidence interval (CI) 1.0120–1.0940], E2 level/follicle (≥12 mm) (aOR 0.99, 95 % CI 0.9888–0.9972) and progesterone level (aOR 0.41, 95 % CI 0.2402–0.6649) on the trigger day were significantly associated with low ORR. Receiver operator characteristic curve analyses revealed that serum E2 level/follicle (≥12 mm) had an area under the curve of 0.7036 (95 % CI 0.65–0.76; p < 0.01). The cut-off value was 169.2 pg/ml, with sensitivity of 65 % and specificity of 65 %, for predicting low ORR. Low ORR was associated with fewer top-quality embryos and more cycles with no embryos available for transfer. The rates of metaphase II oocytes, top-quality embryos, clinical pregnancy and live birth did not differ between the two groups.
Serum E2 level/follicle (≥12 mm) on the trigger day may be used as a predictive factor for low ORR in patients with PCOS. Low ORR may not affect oocyte and embryo developmental potential under appropriate ovarian stimulation management, but likely increases the risk of no embryos being available for transfer.</description><subject>Adult</subject><subject>Estradiol - blood</subject><subject>Female</subject><subject>Fertilization in Vitro - methods</subject><subject>Humans</subject><subject>In-vitro fertilization</subject><subject>Infertility, Female - blood</subject><subject>Infertility, Female - etiology</subject><subject>Infertility, Female - therapy</subject><subject>Oocyte Retrieval</subject><subject>Ovulation Induction - methods</subject><subject>Polycystic ovary syndrome</subject><subject>Polycystic Ovary Syndrome - blood</subject><subject>Polycystic Ovary Syndrome - complications</subject><subject>Polycystic Ovary Syndrome - therapy</subject><subject>Pregnancy</subject><subject>Pregnancy outcome</subject><subject>Pregnancy Rate</subject><subject>Retrospective Studies</subject><issn>0301-2115</issn><issn>1872-7654</issn><issn>1872-7654</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kD1vFDEQhi0EIkfgHyDkkmYXj72fDRKKSIgUKQ3UltceHz7t2YftvWip88Px6ULKTDPN886reQj5CKwGBt2XXY27sI1TzRlvaoCa8eEV2cDQ86rv2uY12TDBoOIA7QV5l9KOlRFifEsuxNixgbNhQx5vvZ0X9Nr5LbVK5xATVd5QtBZ1TjRYOocHGoJeM9KIOTo8qpk6Tw8qO_SFeXD5Nz2EedVryk7TcFRxpWn1JoY90sUbjNtwanC-OrocA7UYs5vd33Ii-PfkjVVzwg9P-5L8uv7-8-pHdXd_c3v17a7SvIFctTB1Ayg-tawVaEZuLCIAdDCh0OM0qrFrBO8BLLMap7G3SnRGcW36pusbcUk-n-8eYvizYMpy75LGeVYew5KkANGwrh05FLQ5ozqGlCJaeYhuX96SwOTJv9zJs3958i8BZPFfYp-eGpZpj-Y59F94Ab6eASx_Hh1GmXSRqNG4WHxLE9zLDf8AdI2cSw</recordid><startdate>202501</startdate><enddate>202501</enddate><creator>Yin, Huiqun</creator><creator>Zhu, Jie</creator><creator>Wang, Cunli</creator><creator>Luan, Kang</creator><creator>Wu, Yan</creator><creator>Ni, Feng</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202501</creationdate><title>Influencing factors and effects of low oocyte retrieval in patients with polycystic ovary syndrome undergoing in-vitro fertilization</title><author>Yin, Huiqun ; Zhu, Jie ; Wang, Cunli ; Luan, Kang ; Wu, Yan ; Ni, Feng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c241t-51b681a2b5053ed92dfee11161be3c9b9a96432711f0fceb97fa36da2cd746743</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Adult</topic><topic>Estradiol - blood</topic><topic>Female</topic><topic>Fertilization in Vitro - methods</topic><topic>Humans</topic><topic>In-vitro fertilization</topic><topic>Infertility, Female - blood</topic><topic>Infertility, Female - etiology</topic><topic>Infertility, Female - therapy</topic><topic>Oocyte Retrieval</topic><topic>Ovulation Induction - methods</topic><topic>Polycystic ovary syndrome</topic><topic>Polycystic Ovary Syndrome - blood</topic><topic>Polycystic Ovary Syndrome - complications</topic><topic>Polycystic Ovary Syndrome - therapy</topic><topic>Pregnancy</topic><topic>Pregnancy outcome</topic><topic>Pregnancy Rate</topic><topic>Retrospective Studies</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yin, Huiqun</creatorcontrib><creatorcontrib>Zhu, Jie</creatorcontrib><creatorcontrib>Wang, Cunli</creatorcontrib><creatorcontrib>Luan, Kang</creatorcontrib><creatorcontrib>Wu, Yan</creatorcontrib><creatorcontrib>Ni, Feng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yin, Huiqun</au><au>Zhu, Jie</au><au>Wang, Cunli</au><au>Luan, Kang</au><au>Wu, Yan</au><au>Ni, Feng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influencing factors and effects of low oocyte retrieval in patients with polycystic ovary syndrome undergoing in-vitro fertilization</atitle><jtitle>European journal of obstetrics & gynecology and reproductive biology</jtitle><addtitle>Eur J Obstet Gynecol Reprod Biol</addtitle><date>2025-01</date><risdate>2025</risdate><volume>304</volume><spage>97</spage><epage>103</epage><pages>97-103</pages><issn>0301-2115</issn><issn>1872-7654</issn><eissn>1872-7654</eissn><abstract>•E2 level/follicle (≥12 mm) on the trigger day could predict low oocyte retrieval events in patients with PCOS.•Low oocyte retrieval may not affect oocyte and embryo developmental potential.•Low oocyte retrieval may increase the risk of no embryo available for transfer.
To investigate influencing factors and effects of low oocyte retrieval in patients with polycystic ovary syndrome (PCOS) undergoing in-vitro fertilization (IVF).
In total, 720 patients with PCOS undergoing IVF were enrolled in this retrospective study from January 2017 to December 2022. The oocyte retrieval rate (ORR) was defined as the ratio of the number of oocytes retrieved to the number of follicles ≥ 12 mm in diameter on the trigger day. Using 1 standard deviation from the mean ORR as the boundary value, patients were divided into low and normal ORR groups. Patient characteristics, stimulation protocols, serum hormone levels, oocyte maturity, embryo developmental quality, and pregnancy outcomes of fresh transfer cycles were analysed.
ORR ranged from 0.06 to 2.69, with a mean value of 1.02. Compared with the normal ORR group (ORR ≥ 0.65), patients in the low ORR group (ORR < 0.65) had a higher body mass index; higher antral follicle count (AFC); more days of gonadotrophin stimulation; and lower serum oestradiol (E2) level, lower progesterone level and lower E2 level/follicle (≥12 mm) on the trigger day. Multivariate logistic regression analysis showed AFC [adjusted odds ratio (aOR) 1.05, 95 % confidence interval (CI) 1.0120–1.0940], E2 level/follicle (≥12 mm) (aOR 0.99, 95 % CI 0.9888–0.9972) and progesterone level (aOR 0.41, 95 % CI 0.2402–0.6649) on the trigger day were significantly associated with low ORR. Receiver operator characteristic curve analyses revealed that serum E2 level/follicle (≥12 mm) had an area under the curve of 0.7036 (95 % CI 0.65–0.76; p < 0.01). The cut-off value was 169.2 pg/ml, with sensitivity of 65 % and specificity of 65 %, for predicting low ORR. Low ORR was associated with fewer top-quality embryos and more cycles with no embryos available for transfer. The rates of metaphase II oocytes, top-quality embryos, clinical pregnancy and live birth did not differ between the two groups.
Serum E2 level/follicle (≥12 mm) on the trigger day may be used as a predictive factor for low ORR in patients with PCOS. Low ORR may not affect oocyte and embryo developmental potential under appropriate ovarian stimulation management, but likely increases the risk of no embryos being available for transfer.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>39608208</pmid><doi>10.1016/j.ejogrb.2024.11.028</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Estradiol - blood Female Fertilization in Vitro - methods Humans In-vitro fertilization Infertility, Female - blood Infertility, Female - etiology Infertility, Female - therapy Oocyte Retrieval Ovulation Induction - methods Polycystic ovary syndrome Polycystic Ovary Syndrome - blood Polycystic Ovary Syndrome - complications Polycystic Ovary Syndrome - therapy Pregnancy Pregnancy outcome Pregnancy Rate Retrospective Studies |
| title | Influencing factors and effects of low oocyte retrieval in patients with polycystic ovary syndrome undergoing in-vitro fertilization |
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