Precise and panoramic study on the nutritional components of specific milk of goats and sheep
This study analyzed human, goat, sheep, and pig milks using metabolomics, lipidomics, and proteomics, specifically untargeted LC-MS/MS metabolomics, untargeted LC-MS/MS lipidomics, and 4D-label-free proteomics. The aim was to determine differences among these milks and identify components with simil...
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| Veröffentlicht in: | Food chemistry 2025-02, Vol.466, p.142263, Article 142263 |
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| creator | Wang, Xiaowei Li, Qian Zhang, Qiu Wu, Yanzhi Chen, Rui Sun, Yinggang Pan, Yuan Li, Siyi Wang, Zeying |
| description | This study analyzed human, goat, sheep, and pig milks using metabolomics, lipidomics, and proteomics, specifically untargeted LC-MS/MS metabolomics, untargeted LC-MS/MS lipidomics, and 4D-label-free proteomics. The aim was to determine differences among these milks and identify components with similar functions to human milk, providing a reference for the research and development of infant formulae. In goat milk, expression of lactoperoxidase, inosine, and allantoin were relatively high, while in sheep milk, concentrations of ceruloplasmin and alpha-ketoglutarate were higher. The content of linoleic acid (LA) was relatively high in both goat and sheep milks. A relatively high content of milk fat globule EGF factor 8 protein was found in pig milk.
•Alpha-ketoglutarate was present in LCG milk.•Content of medium and short chain fatty acids was high in goat and sheep milks.•Milk fat globule EGF factor 8 protein was expressed in YXP milk.•Echinocystic acid and ceruloplasmin were relatively high in OAS milk.•Lactoperoxidase was present in SNG milk. |
| doi_str_mv | 10.1016/j.foodchem.2024.142263 |
| format | Article |
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•Alpha-ketoglutarate was present in LCG milk.•Content of medium and short chain fatty acids was high in goat and sheep milks.•Milk fat globule EGF factor 8 protein was expressed in YXP milk.•Echinocystic acid and ceruloplasmin were relatively high in OAS milk.•Lactoperoxidase was present in SNG milk.</description><identifier>ISSN: 0308-8146</identifier><identifier>ISSN: 1873-7072</identifier><identifier>EISSN: 1873-7072</identifier><identifier>DOI: 10.1016/j.foodchem.2024.142263</identifier><identifier>PMID: 39608118</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Allantoin ; Alpha-ketoglutarate ; Animals ; Ceruloplasmin ; Goats ; Humans ; Inosine ; Lactoperoxidase ; Metabolomics ; Milk - chemistry ; Milk - metabolism ; Nutritive Value ; Proteomics ; Sheep - metabolism ; Swine ; Tandem Mass Spectrometry</subject><ispartof>Food chemistry, 2025-02, Vol.466, p.142263, Article 142263</ispartof><rights>2024 Elsevier Ltd</rights><rights>Copyright © 2024 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c1608-24948badcf7ebebfd44113b38272011b824d06dccaa36fef7a1f8d01cc7395a93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.foodchem.2024.142263$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>315,781,785,3551,27926,27927,45997</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39608118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wang, Xiaowei</creatorcontrib><creatorcontrib>Li, Qian</creatorcontrib><creatorcontrib>Zhang, Qiu</creatorcontrib><creatorcontrib>Wu, Yanzhi</creatorcontrib><creatorcontrib>Chen, Rui</creatorcontrib><creatorcontrib>Sun, Yinggang</creatorcontrib><creatorcontrib>Pan, Yuan</creatorcontrib><creatorcontrib>Li, Siyi</creatorcontrib><creatorcontrib>Wang, Zeying</creatorcontrib><title>Precise and panoramic study on the nutritional components of specific milk of goats and sheep</title><title>Food chemistry</title><addtitle>Food Chem</addtitle><description>This study analyzed human, goat, sheep, and pig milks using metabolomics, lipidomics, and proteomics, specifically untargeted LC-MS/MS metabolomics, untargeted LC-MS/MS lipidomics, and 4D-label-free proteomics. The aim was to determine differences among these milks and identify components with similar functions to human milk, providing a reference for the research and development of infant formulae. In goat milk, expression of lactoperoxidase, inosine, and allantoin were relatively high, while in sheep milk, concentrations of ceruloplasmin and alpha-ketoglutarate were higher. The content of linoleic acid (LA) was relatively high in both goat and sheep milks. A relatively high content of milk fat globule EGF factor 8 protein was found in pig milk.
•Alpha-ketoglutarate was present in LCG milk.•Content of medium and short chain fatty acids was high in goat and sheep milks.•Milk fat globule EGF factor 8 protein was expressed in YXP milk.•Echinocystic acid and ceruloplasmin were relatively high in OAS milk.•Lactoperoxidase was present in SNG milk.</description><subject>Allantoin</subject><subject>Alpha-ketoglutarate</subject><subject>Animals</subject><subject>Ceruloplasmin</subject><subject>Goats</subject><subject>Humans</subject><subject>Inosine</subject><subject>Lactoperoxidase</subject><subject>Metabolomics</subject><subject>Milk - chemistry</subject><subject>Milk - metabolism</subject><subject>Nutritive Value</subject><subject>Proteomics</subject><subject>Sheep - metabolism</subject><subject>Swine</subject><subject>Tandem Mass Spectrometry</subject><issn>0308-8146</issn><issn>1873-7072</issn><issn>1873-7072</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2025</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkE1P3DAQhi1UBMvHX0A-9pKtxzaJ99YKtVAJqRzgiCzHHrPeJnZqJ5X49_VqoVdOI3med2b8EHIFbA0M2i-7tU_J2S2Oa864XIPkvBVHZAWqE03HOv6JrJhgqlEg21NyVsqOMcYZqBNyKjYtUwBqRZ4fMtpQkJro6GRiymYMlpZ5ca80RTpvkcZlzmEOKZqB2jROKWKcC02elqmGfeXHMPzeP7wkUzv7WWWLOF2QY2-Ggpdv9Zw8_fj-eHPX3P-6_Xnz7b6xUA9puNxI1RtnfYc99t5JCSB6oXhXD4ZecelY66w1RrQefWfAK8fA2k5srs1GnJPPh7lTTn8WLLMeQ7E4DCZiWooWICRrr1UnK9oeUJtTKRm9nnIYTX7VwPRerd7pd7V6r1Yf1Nbg1duOpR_R_Y-9u6zA1wOA9ad_A2ZdbMBo0YXqeNYuhY92_AOIf46S</recordid><startdate>20250228</startdate><enddate>20250228</enddate><creator>Wang, Xiaowei</creator><creator>Li, Qian</creator><creator>Zhang, Qiu</creator><creator>Wu, Yanzhi</creator><creator>Chen, Rui</creator><creator>Sun, Yinggang</creator><creator>Pan, Yuan</creator><creator>Li, Siyi</creator><creator>Wang, Zeying</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20250228</creationdate><title>Precise and panoramic study on the nutritional components of specific milk of goats and sheep</title><author>Wang, Xiaowei ; Li, Qian ; Zhang, Qiu ; Wu, Yanzhi ; Chen, Rui ; Sun, Yinggang ; Pan, Yuan ; Li, Siyi ; Wang, Zeying</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1608-24948badcf7ebebfd44113b38272011b824d06dccaa36fef7a1f8d01cc7395a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2025</creationdate><topic>Allantoin</topic><topic>Alpha-ketoglutarate</topic><topic>Animals</topic><topic>Ceruloplasmin</topic><topic>Goats</topic><topic>Humans</topic><topic>Inosine</topic><topic>Lactoperoxidase</topic><topic>Metabolomics</topic><topic>Milk - chemistry</topic><topic>Milk - metabolism</topic><topic>Nutritive Value</topic><topic>Proteomics</topic><topic>Sheep - metabolism</topic><topic>Swine</topic><topic>Tandem Mass Spectrometry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wang, Xiaowei</creatorcontrib><creatorcontrib>Li, Qian</creatorcontrib><creatorcontrib>Zhang, Qiu</creatorcontrib><creatorcontrib>Wu, Yanzhi</creatorcontrib><creatorcontrib>Chen, Rui</creatorcontrib><creatorcontrib>Sun, Yinggang</creatorcontrib><creatorcontrib>Pan, Yuan</creatorcontrib><creatorcontrib>Li, Siyi</creatorcontrib><creatorcontrib>Wang, Zeying</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wang, Xiaowei</au><au>Li, Qian</au><au>Zhang, Qiu</au><au>Wu, Yanzhi</au><au>Chen, Rui</au><au>Sun, Yinggang</au><au>Pan, Yuan</au><au>Li, Siyi</au><au>Wang, Zeying</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Precise and panoramic study on the nutritional components of specific milk of goats and sheep</atitle><jtitle>Food chemistry</jtitle><addtitle>Food Chem</addtitle><date>2025-02-28</date><risdate>2025</risdate><volume>466</volume><spage>142263</spage><pages>142263-</pages><artnum>142263</artnum><issn>0308-8146</issn><issn>1873-7072</issn><eissn>1873-7072</eissn><abstract>This study analyzed human, goat, sheep, and pig milks using metabolomics, lipidomics, and proteomics, specifically untargeted LC-MS/MS metabolomics, untargeted LC-MS/MS lipidomics, and 4D-label-free proteomics. The aim was to determine differences among these milks and identify components with similar functions to human milk, providing a reference for the research and development of infant formulae. In goat milk, expression of lactoperoxidase, inosine, and allantoin were relatively high, while in sheep milk, concentrations of ceruloplasmin and alpha-ketoglutarate were higher. The content of linoleic acid (LA) was relatively high in both goat and sheep milks. A relatively high content of milk fat globule EGF factor 8 protein was found in pig milk.
•Alpha-ketoglutarate was present in LCG milk.•Content of medium and short chain fatty acids was high in goat and sheep milks.•Milk fat globule EGF factor 8 protein was expressed in YXP milk.•Echinocystic acid and ceruloplasmin were relatively high in OAS milk.•Lactoperoxidase was present in SNG milk.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>39608118</pmid><doi>10.1016/j.foodchem.2024.142263</doi></addata></record> |
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| subjects | Allantoin Alpha-ketoglutarate Animals Ceruloplasmin Goats Humans Inosine Lactoperoxidase Metabolomics Milk - chemistry Milk - metabolism Nutritive Value Proteomics Sheep - metabolism Swine Tandem Mass Spectrometry |
| title | Precise and panoramic study on the nutritional components of specific milk of goats and sheep |
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