Blockade of purine metabolism reverses macrophage immunosuppression and enhances anti-tumor immunity in non-small cell lung cancer

Immune checkpoint blockade therapy is not effective in most patients with non-small cell lung cancer (NSCLC) due to the immunosuppressive tumor microenvironment. Macrophages are key components of tumor-infiltrating immune cells and play a critical role in immunosuppression, which can be mediated by...

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Veröffentlicht in:	Drug resistance updates 2025-01, Vol.78, p.101175, Article 101175
Hauptverfasser:	Yang, Li, Li, Aitian, Yu, Weina, Wang, Huishang, Zhang, Lei, Wang, Dan, Wang, Ying, Zhang, Ru, Lei, Qingyang, Liu, Zhangnan, Zhen, Shanshan, Qin, Haiming, Liu, Yaqing, Yang, Yang, Song, Xian-Lu, Zhang, Yi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - immunology Carcinoma, Non-Small-Cell Lung - pathology Cell Line, Tumor CXCL8 Humans Immune checkpoint Immune Checkpoint Inhibitors - pharmacology Immune Checkpoint Inhibitors - therapeutic use Immunotherapy - methods Lung Neoplasms - drug therapy Lung Neoplasms - immunology Lung Neoplasms - metabolism Lung Neoplasms - pathology Macrophages - immunology Macrophages - metabolism Mice Mice, Inbred C57BL NSCLC Purine metabolism Purines - pharmacology TAMs Tumor Microenvironment - drug effects Tumor Microenvironment - immunology Tumor-Associated Macrophages - drug effects Tumor-Associated Macrophages - immunology Tumor-Associated Macrophages - metabolism
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