The Effect of Silymarin on the Prevention of Atrial Fibrillation After Coronary Artery Bypass Grafting
Postoperative atrial fibrillation is a frequent complication after coronary artery bypass grafting and is associated with increased mortality. The effects of various drugs on the occurrence of postoperative atrial fibrillation have been studied, but no one has looked into the effect of silymarin on...
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| Veröffentlicht in: | Revista brasileira de cirurgia cardiovascular 2024-11, Vol.e20230422 (e20230422) |
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| container_title | Revista brasileira de cirurgia cardiovascular |
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| creator | Okiljevic, Bogdan Zdravkovic, Ranko Preveden, Andrej Preveden, Mihaela Mladenovic, Nikola Susak, Stamenko |
| description | Postoperative atrial fibrillation is a frequent complication after coronary artery bypass grafting and is associated with increased mortality. The effects of various drugs on the occurrence of postoperative atrial fibrillation have been studied, but no one has looked into the effect of silymarin on the occurrence of postoperative atrial fibrillation.
This prospective experimental study included 160 patients undergoing coronary artery bypass grafting. The experimental group received 400 mg of silymarin orally three days before the surgery, while the control group did not. The occurrence of postoperative atrial fibrillation was monitored. Patients' clinical data and postoperative characteristics were investigated to elucidate their impact on postoperative atrial fibrillation.
Postoperative atrial fibrillation occurred in significantly fewer patients in the experimental group (14 vs. 30, P=0.008). There were also lower mean values of postoperatively measured C-reactive protein (P |
| doi_str_mv | 10.21470/1678-9741-2023-0422 |
| format | Article |
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This prospective experimental study included 160 patients undergoing coronary artery bypass grafting. The experimental group received 400 mg of silymarin orally three days before the surgery, while the control group did not. The occurrence of postoperative atrial fibrillation was monitored. Patients' clinical data and postoperative characteristics were investigated to elucidate their impact on postoperative atrial fibrillation.
Postoperative atrial fibrillation occurred in significantly fewer patients in the experimental group (14 vs. 30, P=0.008). There were also lower mean values of postoperatively measured C-reactive protein (P<0.0005) and aspartate aminotransferase (P=0.001) in the experimental group. Within the multivariate regression model, a non-silymarin group (odds ratio 0.296 [0.109-0.807], P=0.005), postoperative red blood cell transfusion (odds ratio 5.218 [1.930-14.107], P=0.001), left atrial diameter (odds ratio 7.800 [2.122-28.672], P=0.002), postoperative C-reactive protein (odds ratio 1.020 [1.008-1.032], P=0.001), and CHA₂DS₂-VASc score (standing for congestive heart failure, hypertension, age ≥ 75 years [doubled], diabetes, stroke [doubled], vascular disease, age 65 to 74 years, and sex category [female]) (odds ratio 1.873 [1.279-2.743], P=0.001) proved to be independently associated with the development of postoperative atrial fibrillation.
This study showed that preoperative administration of silymarin significantly reduces the development of atrial fibrillation after coronary artery bypass grafting.</description><identifier>ISSN: 1678-9741</identifier><identifier>EISSN: 1678-9741</identifier><identifier>DOI: 10.21470/1678-9741-2023-0422</identifier><identifier>PMID: 39607972</identifier><language>eng</language><publisher>Brazil</publisher><subject>Aged ; Atrial Fibrillation - etiology ; Atrial Fibrillation - prevention & control ; C-Reactive Protein - analysis ; Coronary Artery Bypass - adverse effects ; Female ; Humans ; Male ; Middle Aged ; Postoperative Complications - etiology ; Postoperative Complications - prevention & control ; Prospective Studies ; Risk Factors ; Silymarin - administration & dosage ; Silymarin - therapeutic use ; Treatment Outcome</subject><ispartof>Revista brasileira de cirurgia cardiovascular, 2024-11, Vol.e20230422 (e20230422)</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0001-7383-6771</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39607972$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Okiljevic, Bogdan</creatorcontrib><creatorcontrib>Zdravkovic, Ranko</creatorcontrib><creatorcontrib>Preveden, Andrej</creatorcontrib><creatorcontrib>Preveden, Mihaela</creatorcontrib><creatorcontrib>Mladenovic, Nikola</creatorcontrib><creatorcontrib>Susak, Stamenko</creatorcontrib><title>The Effect of Silymarin on the Prevention of Atrial Fibrillation After Coronary Artery Bypass Grafting</title><title>Revista brasileira de cirurgia cardiovascular</title><addtitle>Braz J Cardiovasc Surg</addtitle><description>Postoperative atrial fibrillation is a frequent complication after coronary artery bypass grafting and is associated with increased mortality. The effects of various drugs on the occurrence of postoperative atrial fibrillation have been studied, but no one has looked into the effect of silymarin on the occurrence of postoperative atrial fibrillation.
This prospective experimental study included 160 patients undergoing coronary artery bypass grafting. The experimental group received 400 mg of silymarin orally three days before the surgery, while the control group did not. The occurrence of postoperative atrial fibrillation was monitored. Patients' clinical data and postoperative characteristics were investigated to elucidate their impact on postoperative atrial fibrillation.
Postoperative atrial fibrillation occurred in significantly fewer patients in the experimental group (14 vs. 30, P=0.008). There were also lower mean values of postoperatively measured C-reactive protein (P<0.0005) and aspartate aminotransferase (P=0.001) in the experimental group. Within the multivariate regression model, a non-silymarin group (odds ratio 0.296 [0.109-0.807], P=0.005), postoperative red blood cell transfusion (odds ratio 5.218 [1.930-14.107], P=0.001), left atrial diameter (odds ratio 7.800 [2.122-28.672], P=0.002), postoperative C-reactive protein (odds ratio 1.020 [1.008-1.032], P=0.001), and CHA₂DS₂-VASc score (standing for congestive heart failure, hypertension, age ≥ 75 years [doubled], diabetes, stroke [doubled], vascular disease, age 65 to 74 years, and sex category [female]) (odds ratio 1.873 [1.279-2.743], P=0.001) proved to be independently associated with the development of postoperative atrial fibrillation.
This study showed that preoperative administration of silymarin significantly reduces the development of atrial fibrillation after coronary artery bypass grafting.</description><subject>Aged</subject><subject>Atrial Fibrillation - etiology</subject><subject>Atrial Fibrillation - prevention & control</subject><subject>C-Reactive Protein - analysis</subject><subject>Coronary Artery Bypass - adverse effects</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Postoperative Complications - etiology</subject><subject>Postoperative Complications - prevention & control</subject><subject>Prospective Studies</subject><subject>Risk Factors</subject><subject>Silymarin - administration & dosage</subject><subject>Silymarin - therapeutic use</subject><subject>Treatment Outcome</subject><issn>1678-9741</issn><issn>1678-9741</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNUN1LwzAQD6K4Of0PRPLoSzWfTfo4xzaFgYLzuaTtRSNdW5NM6H9v0Cm-3N3vgx93h9AlJTeMCkVuaa50VihBM0YYz4hg7AhN_9jjf_MEnYXwTghTXJNTNOFFTlSh2BTZ7RvgpbVQR9xb_OzacWe863Df4ZikJw-f0EWXYJLn0TvT4pWrvGtb803PbQSPF73vO-NHPPcJjvhuHEwIeO2Nja57PUcn1rQBLg59hl5Wy-3iPts8rh8W8002UEFjpqSpCJHSatGYQlY5MRosgG4MS9XqWuWiFpWSNi-UbhjUhjJTgdRM81zyGbr-yR18_7GHEMudCzWkXTvo96HklAuSS1noZL06WPfVDppy8C5dPpa_v-FfiSVnuw</recordid><startdate>20241128</startdate><enddate>20241128</enddate><creator>Okiljevic, Bogdan</creator><creator>Zdravkovic, Ranko</creator><creator>Preveden, Andrej</creator><creator>Preveden, Mihaela</creator><creator>Mladenovic, Nikola</creator><creator>Susak, Stamenko</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-7383-6771</orcidid></search><sort><creationdate>20241128</creationdate><title>The Effect of Silymarin on the Prevention of Atrial Fibrillation After Coronary Artery Bypass Grafting</title><author>Okiljevic, Bogdan ; Zdravkovic, Ranko ; Preveden, Andrej ; Preveden, Mihaela ; Mladenovic, Nikola ; Susak, Stamenko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p141t-75ab0055f84da95b60a8efee8da2ee8f8c764c4b75f6978d2eca12abe58283653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Atrial Fibrillation - etiology</topic><topic>Atrial Fibrillation - prevention & control</topic><topic>C-Reactive Protein - analysis</topic><topic>Coronary Artery Bypass - adverse effects</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Postoperative Complications - etiology</topic><topic>Postoperative Complications - prevention & control</topic><topic>Prospective Studies</topic><topic>Risk Factors</topic><topic>Silymarin - administration & dosage</topic><topic>Silymarin - therapeutic use</topic><topic>Treatment Outcome</topic><toplevel>online_resources</toplevel><creatorcontrib>Okiljevic, Bogdan</creatorcontrib><creatorcontrib>Zdravkovic, Ranko</creatorcontrib><creatorcontrib>Preveden, Andrej</creatorcontrib><creatorcontrib>Preveden, Mihaela</creatorcontrib><creatorcontrib>Mladenovic, Nikola</creatorcontrib><creatorcontrib>Susak, Stamenko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Revista brasileira de cirurgia cardiovascular</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Okiljevic, Bogdan</au><au>Zdravkovic, Ranko</au><au>Preveden, Andrej</au><au>Preveden, Mihaela</au><au>Mladenovic, Nikola</au><au>Susak, Stamenko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Effect of Silymarin on the Prevention of Atrial Fibrillation After Coronary Artery Bypass Grafting</atitle><jtitle>Revista brasileira de cirurgia cardiovascular</jtitle><addtitle>Braz J Cardiovasc Surg</addtitle><date>2024-11-28</date><risdate>2024</risdate><volume>e20230422</volume><issue>e20230422</issue><issn>1678-9741</issn><eissn>1678-9741</eissn><abstract>Postoperative atrial fibrillation is a frequent complication after coronary artery bypass grafting and is associated with increased mortality. The effects of various drugs on the occurrence of postoperative atrial fibrillation have been studied, but no one has looked into the effect of silymarin on the occurrence of postoperative atrial fibrillation.
This prospective experimental study included 160 patients undergoing coronary artery bypass grafting. The experimental group received 400 mg of silymarin orally three days before the surgery, while the control group did not. The occurrence of postoperative atrial fibrillation was monitored. Patients' clinical data and postoperative characteristics were investigated to elucidate their impact on postoperative atrial fibrillation.
Postoperative atrial fibrillation occurred in significantly fewer patients in the experimental group (14 vs. 30, P=0.008). There were also lower mean values of postoperatively measured C-reactive protein (P<0.0005) and aspartate aminotransferase (P=0.001) in the experimental group. Within the multivariate regression model, a non-silymarin group (odds ratio 0.296 [0.109-0.807], P=0.005), postoperative red blood cell transfusion (odds ratio 5.218 [1.930-14.107], P=0.001), left atrial diameter (odds ratio 7.800 [2.122-28.672], P=0.002), postoperative C-reactive protein (odds ratio 1.020 [1.008-1.032], P=0.001), and CHA₂DS₂-VASc score (standing for congestive heart failure, hypertension, age ≥ 75 years [doubled], diabetes, stroke [doubled], vascular disease, age 65 to 74 years, and sex category [female]) (odds ratio 1.873 [1.279-2.743], P=0.001) proved to be independently associated with the development of postoperative atrial fibrillation.
This study showed that preoperative administration of silymarin significantly reduces the development of atrial fibrillation after coronary artery bypass grafting.</abstract><cop>Brazil</cop><pmid>39607972</pmid><doi>10.21470/1678-9741-2023-0422</doi><orcidid>https://orcid.org/0000-0001-7383-6771</orcidid></addata></record> |
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| source | MEDLINE; PubMed Central Open Access; PubMed Central |
| subjects | Aged Atrial Fibrillation - etiology Atrial Fibrillation - prevention & control C-Reactive Protein - analysis Coronary Artery Bypass - adverse effects Female Humans Male Middle Aged Postoperative Complications - etiology Postoperative Complications - prevention & control Prospective Studies Risk Factors Silymarin - administration & dosage Silymarin - therapeutic use Treatment Outcome |
| title | The Effect of Silymarin on the Prevention of Atrial Fibrillation After Coronary Artery Bypass Grafting |
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