Brominated chalcones as promising antileishmanial agents

[Display omitted] •Synthesis of 21 brominated chalcones via Claisen-Schmidt condensation.•Brominated chalcones show high antiprotozoal activity against Leishmania amazonensis.•Low cytotoxicity of chalcones at 50 µM in L929 fibroblasts.•Brominated chalcones present potential for developing new antile...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2025-02, Vol.116, p.130042, Article 130042
Hauptverfasser:	Barreto, Tayssa S.A., Santos, Tamiris A.C., Silva, Audrey R.S.T., Costa, Emmanoel V., Pinheiro, Liciane A., Fernandes, Roberta P.M., Scher, Ricardo, Alves, Péricles B.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antiprotozoal activity Antiprotozoal Agents - chemical synthesis Antiprotozoal Agents - chemistry Antiprotozoal Agents - pharmacology Cell Line Cell Survival - drug effects Chalcones - chemical synthesis Chalcones - chemistry Chalcones - pharmacology Cytotoxicity Dose-Response Relationship, Drug Fibroblasts - drug effects Halogenated chalcones Halogenation Leishmania - drug effects Leishmania amazonensis Mice Molecular Structure Parasitic Sensitivity Tests Structure-Activity Relationship Trypanosomatids
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