Determination of Serum Glycogen Synthase 3 Beta Levels in Patients with Heart Failure, a Novel Marker for Diagnosis and Defining Disease Severity?
Glycogen synthase kinase 3β (GSK3β) is an enzyme that has roles in the pathogenesis of heart failure (HF). We try to reveal serum GSK3β levels in types of HF. In this study, we evaluated serum GSK3β levels in HF patients. Also, we tried to elucidate any possible relationship between serum GSK3β leve...
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| Veröffentlicht in: | Arquivos brasileiros de cardiologia 2024, Vol.121 (11), p.e20240155 |
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| creator | Altunbas, Gokhan Kaplan, Mehmet Duzen, Veysel Kaya, Emin Erdem Gokdeniz, Hafize Gokce Taysi, Seyithan |
| description | Glycogen synthase kinase 3β (GSK3β) is an enzyme that has roles in the pathogenesis of heart failure (HF). We try to reveal serum GSK3β levels in types of HF.
In this study, we evaluated serum GSK3β levels in HF patients. Also, we tried to elucidate any possible relationship between serum GSK3β levels and disease severity among three different types of HF patients.
We performed a prospective study and enrolled 112 patients: 50 patients in heart failure with preserved ejection fraction (HFpEF) group, 30 patients in heart failure with mildly reduced ejection fraction (HFmrEF) group, and 32 patients in heart failure with reduced ejection fraction group (HFrEF). We also evaluated 50 healthy controls. Echocardiographic examinations were performed. We measured serum GSK-3β and N-terminal pro-B-type natriuretic peptide (NT-proBNP). We measured highly sensitive C-reactive protein (hs-CRP) levels and calculated neutrophil-lymphocyte ratio (NLR) platelets-to-lymphocyte ratio (PLR) from the hemogram count. Statistical significance was accepted p < 0.05.
Serum GSK3β levels were significantly higher among patients with HF compared to healthy controls (median GSK3β levels; 117.26 (45.39 -223.85) vs 13.91 (5.6 -23.3) ng/mL, p |
| doi_str_mv | 10.36660/abc.20240155 |
| format | Article |
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In this study, we evaluated serum GSK3β levels in HF patients. Also, we tried to elucidate any possible relationship between serum GSK3β levels and disease severity among three different types of HF patients.
We performed a prospective study and enrolled 112 patients: 50 patients in heart failure with preserved ejection fraction (HFpEF) group, 30 patients in heart failure with mildly reduced ejection fraction (HFmrEF) group, and 32 patients in heart failure with reduced ejection fraction group (HFrEF). We also evaluated 50 healthy controls. Echocardiographic examinations were performed. We measured serum GSK-3β and N-terminal pro-B-type natriuretic peptide (NT-proBNP). We measured highly sensitive C-reactive protein (hs-CRP) levels and calculated neutrophil-lymphocyte ratio (NLR) platelets-to-lymphocyte ratio (PLR) from the hemogram count. Statistical significance was accepted p < 0.05.
Serum GSK3β levels were significantly higher among patients with HF compared to healthy controls (median GSK3β levels; 117.26 (45.39 -223.85) vs 13.91 (5.6 -23.3) ng/mL, p<0.001). Also, GSK3β levels were highest among patients with HFpEF and lowest among patients with HFrEF; 236.44 (132.89 -432) vs. 38.72 (23.15-67.31) ng/mL respectively (p<0.001). Median NT-proBNP levels, as expected, were significantly higher among patients with HF compared to healthy controls (660 (291 -1000) vs. 92 (78 -102) pg/mL, p<0.001). As a marker of systemic inflammation, hsCRP values, NLR, and PLR did not differ significantly among HF patients and controls.
GSK3β levels were significantly higher among patients with HF. Also, as the ejection fraction declines, GSK3β levels also reduce, probably as a protective mechanism to prevent further apoptosis and myocyte death.</description><identifier>ISSN: 1678-4170</identifier><identifier>EISSN: 1678-4170</identifier><identifier>DOI: 10.36660/abc.20240155</identifier><identifier>PMID: 39607223</identifier><language>eng ; por</language><publisher>Brazil</publisher><subject>Aged ; Biomarkers - blood ; C-Reactive Protein - analysis ; Case-Control Studies ; Echocardiography ; Female ; Glycogen Synthase Kinase 3 beta - blood ; Heart Failure - blood ; Heart Failure - physiopathology ; Humans ; Male ; Middle Aged ; Natriuretic Peptide, Brain - blood ; Peptide Fragments - blood ; Prospective Studies ; Reference Values ; Severity of Illness Index ; Statistics, Nonparametric ; Stroke Volume - physiology</subject><ispartof>Arquivos brasileiros de cardiologia, 2024, Vol.121 (11), p.e20240155</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0003-1251-3148 ; 0000-0003-0681-3267 ; 0000-0001-7081-5799</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39607223$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Altunbas, Gokhan</creatorcontrib><creatorcontrib>Kaplan, Mehmet</creatorcontrib><creatorcontrib>Duzen, Veysel</creatorcontrib><creatorcontrib>Kaya, Emin Erdem</creatorcontrib><creatorcontrib>Gokdeniz, Hafize Gokce</creatorcontrib><creatorcontrib>Taysi, Seyithan</creatorcontrib><title>Determination of Serum Glycogen Synthase 3 Beta Levels in Patients with Heart Failure, a Novel Marker for Diagnosis and Defining Disease Severity?</title><title>Arquivos brasileiros de cardiologia</title><addtitle>Arq Bras Cardiol</addtitle><description>Glycogen synthase kinase 3β (GSK3β) is an enzyme that has roles in the pathogenesis of heart failure (HF). We try to reveal serum GSK3β levels in types of HF.
In this study, we evaluated serum GSK3β levels in HF patients. Also, we tried to elucidate any possible relationship between serum GSK3β levels and disease severity among three different types of HF patients.
We performed a prospective study and enrolled 112 patients: 50 patients in heart failure with preserved ejection fraction (HFpEF) group, 30 patients in heart failure with mildly reduced ejection fraction (HFmrEF) group, and 32 patients in heart failure with reduced ejection fraction group (HFrEF). We also evaluated 50 healthy controls. Echocardiographic examinations were performed. We measured serum GSK-3β and N-terminal pro-B-type natriuretic peptide (NT-proBNP). We measured highly sensitive C-reactive protein (hs-CRP) levels and calculated neutrophil-lymphocyte ratio (NLR) platelets-to-lymphocyte ratio (PLR) from the hemogram count. Statistical significance was accepted p < 0.05.
Serum GSK3β levels were significantly higher among patients with HF compared to healthy controls (median GSK3β levels; 117.26 (45.39 -223.85) vs 13.91 (5.6 -23.3) ng/mL, p<0.001). Also, GSK3β levels were highest among patients with HFpEF and lowest among patients with HFrEF; 236.44 (132.89 -432) vs. 38.72 (23.15-67.31) ng/mL respectively (p<0.001). Median NT-proBNP levels, as expected, were significantly higher among patients with HF compared to healthy controls (660 (291 -1000) vs. 92 (78 -102) pg/mL, p<0.001). As a marker of systemic inflammation, hsCRP values, NLR, and PLR did not differ significantly among HF patients and controls.
GSK3β levels were significantly higher among patients with HF. Also, as the ejection fraction declines, GSK3β levels also reduce, probably as a protective mechanism to prevent further apoptosis and myocyte death.</description><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>C-Reactive Protein - analysis</subject><subject>Case-Control Studies</subject><subject>Echocardiography</subject><subject>Female</subject><subject>Glycogen Synthase Kinase 3 beta - blood</subject><subject>Heart Failure - blood</subject><subject>Heart Failure - physiopathology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Natriuretic Peptide, Brain - blood</subject><subject>Peptide Fragments - blood</subject><subject>Prospective Studies</subject><subject>Reference Values</subject><subject>Severity of Illness Index</subject><subject>Statistics, Nonparametric</subject><subject>Stroke Volume - physiology</subject><issn>1678-4170</issn><issn>1678-4170</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkMtOwzAQRS0E4r1ki2bJgsLYTpxmhYDSglQeUmFdOc6kGBKn2A6ov8EXEwRILEZzNTr3LIaxA44nUimFp7owJwJFgjxN19g2V9lwkPAM1__lLbYTwguiEJlMN9mWzBVmQsht9jmiSL6xTkfbOmgrmJHvGpjUK9MuyMFs5eKzDgQSLihqmNI71QGsg4e-Qi4G-LDxGa5J-whjbevO0zFouGt7EG61fyUPVethZPXCtcEG0K6EEVXWWbfoz4G-_bNe7G1cne2xjUrXgfZ_9y57Gl89Xl4PpveTm8vz6WDJEx4HVBY4zKVQKFPB0QgzJGVQVEaUqkgyQWlB2iiisiyTjAsjRJ4jDk2RSuxnlx39eJe-fesoxHljg6G61o7aLswllzKTOWbYo4e_aFc0VM6X3jbar-Z_f5RfwyF1bw</recordid><startdate>2024</startdate><enddate>2024</enddate><creator>Altunbas, Gokhan</creator><creator>Kaplan, Mehmet</creator><creator>Duzen, Veysel</creator><creator>Kaya, Emin Erdem</creator><creator>Gokdeniz, Hafize Gokce</creator><creator>Taysi, Seyithan</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-1251-3148</orcidid><orcidid>https://orcid.org/0000-0003-0681-3267</orcidid><orcidid>https://orcid.org/0000-0001-7081-5799</orcidid></search><sort><creationdate>2024</creationdate><title>Determination of Serum Glycogen Synthase 3 Beta Levels in Patients with Heart Failure, a Novel Marker for Diagnosis and Defining Disease Severity?</title><author>Altunbas, Gokhan ; Kaplan, Mehmet ; Duzen, Veysel ; Kaya, Emin Erdem ; Gokdeniz, Hafize Gokce ; Taysi, Seyithan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p141t-edb089326035210c2c8e6c02fc2d6b472e5beac6eeddd4712c2299008cb530b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; por</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>C-Reactive Protein - analysis</topic><topic>Case-Control Studies</topic><topic>Echocardiography</topic><topic>Female</topic><topic>Glycogen Synthase Kinase 3 beta - blood</topic><topic>Heart Failure - blood</topic><topic>Heart Failure - physiopathology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Natriuretic Peptide, Brain - blood</topic><topic>Peptide Fragments - blood</topic><topic>Prospective Studies</topic><topic>Reference Values</topic><topic>Severity of Illness Index</topic><topic>Statistics, Nonparametric</topic><topic>Stroke Volume - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Altunbas, Gokhan</creatorcontrib><creatorcontrib>Kaplan, Mehmet</creatorcontrib><creatorcontrib>Duzen, Veysel</creatorcontrib><creatorcontrib>Kaya, Emin Erdem</creatorcontrib><creatorcontrib>Gokdeniz, Hafize Gokce</creatorcontrib><creatorcontrib>Taysi, Seyithan</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Arquivos brasileiros de cardiologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Altunbas, Gokhan</au><au>Kaplan, Mehmet</au><au>Duzen, Veysel</au><au>Kaya, Emin Erdem</au><au>Gokdeniz, Hafize Gokce</au><au>Taysi, Seyithan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Determination of Serum Glycogen Synthase 3 Beta Levels in Patients with Heart Failure, a Novel Marker for Diagnosis and Defining Disease Severity?</atitle><jtitle>Arquivos brasileiros de cardiologia</jtitle><addtitle>Arq Bras Cardiol</addtitle><date>2024</date><risdate>2024</risdate><volume>121</volume><issue>11</issue><spage>e20240155</spage><pages>e20240155-</pages><issn>1678-4170</issn><eissn>1678-4170</eissn><abstract>Glycogen synthase kinase 3β (GSK3β) is an enzyme that has roles in the pathogenesis of heart failure (HF). We try to reveal serum GSK3β levels in types of HF.
In this study, we evaluated serum GSK3β levels in HF patients. Also, we tried to elucidate any possible relationship between serum GSK3β levels and disease severity among three different types of HF patients.
We performed a prospective study and enrolled 112 patients: 50 patients in heart failure with preserved ejection fraction (HFpEF) group, 30 patients in heart failure with mildly reduced ejection fraction (HFmrEF) group, and 32 patients in heart failure with reduced ejection fraction group (HFrEF). We also evaluated 50 healthy controls. Echocardiographic examinations were performed. We measured serum GSK-3β and N-terminal pro-B-type natriuretic peptide (NT-proBNP). We measured highly sensitive C-reactive protein (hs-CRP) levels and calculated neutrophil-lymphocyte ratio (NLR) platelets-to-lymphocyte ratio (PLR) from the hemogram count. Statistical significance was accepted p < 0.05.
Serum GSK3β levels were significantly higher among patients with HF compared to healthy controls (median GSK3β levels; 117.26 (45.39 -223.85) vs 13.91 (5.6 -23.3) ng/mL, p<0.001). Also, GSK3β levels were highest among patients with HFpEF and lowest among patients with HFrEF; 236.44 (132.89 -432) vs. 38.72 (23.15-67.31) ng/mL respectively (p<0.001). Median NT-proBNP levels, as expected, were significantly higher among patients with HF compared to healthy controls (660 (291 -1000) vs. 92 (78 -102) pg/mL, p<0.001). As a marker of systemic inflammation, hsCRP values, NLR, and PLR did not differ significantly among HF patients and controls.
GSK3β levels were significantly higher among patients with HF. Also, as the ejection fraction declines, GSK3β levels also reduce, probably as a protective mechanism to prevent further apoptosis and myocyte death.</abstract><cop>Brazil</cop><pmid>39607223</pmid><doi>10.36660/abc.20240155</doi><orcidid>https://orcid.org/0000-0003-1251-3148</orcidid><orcidid>https://orcid.org/0000-0003-0681-3267</orcidid><orcidid>https://orcid.org/0000-0001-7081-5799</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Aged Biomarkers - blood C-Reactive Protein - analysis Case-Control Studies Echocardiography Female Glycogen Synthase Kinase 3 beta - blood Heart Failure - blood Heart Failure - physiopathology Humans Male Middle Aged Natriuretic Peptide, Brain - blood Peptide Fragments - blood Prospective Studies Reference Values Severity of Illness Index Statistics, Nonparametric Stroke Volume - physiology |
| title | Determination of Serum Glycogen Synthase 3 Beta Levels in Patients with Heart Failure, a Novel Marker for Diagnosis and Defining Disease Severity? |
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