Osteoprotegerin and Vascular Dysfunction in Patients with Stage 3 Chronic Kidney Disease and Those without Renal Dysfunction: A Case-Control Study
Osteoprotegerin (OPG) is a marker of vascular calcification and cardiovascular risk in patients with chronic kidney disease (CKD). This study aimed to compare and correlate OPG values with flow-mediated dilation (FMD) and pulse wave velocity (PWV) measurements in patients in stage 3 CKD and those wi...
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| Veröffentlicht in: | Arquivos brasileiros de cardiologia 2024-10, Vol.121 (11), p.e20240122 |
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| creator | Matos, Thalita de Oliveira Vitorino, Priscila Valverde de Oliveira Orlow, Rogerio Melo, Átila de Oliveira Amorim, Diogo da Silva Sousa, Gleidson Junio Oliveira Jorgetti, Vanda Sousa, Ana Luiza Lima Bezerra, Rodrigo Barroso, Weimar Kunz Sebba |
| description | Osteoprotegerin (OPG) is a marker of vascular calcification and cardiovascular risk in patients with chronic kidney disease (CKD).
This study aimed to compare and correlate OPG values with flow-mediated dilation (FMD) and pulse wave velocity (PWV) measurements in patients in stage 3 CKD and those without renal dysfunction.
This case-control study was conducted in a specialized hypertension center in 2022. A total of 79 patients over 18 years of age participated in the study. The case group consisted of 30 patients with moderate renal dysfunction (CKD stage 3) and the control group included 49 individuals with glomerular filtration rate ≥ 60 mL/min/1.73 m2. The significance level adopted in the statistical analysis was 5%.
Central pulse pressure (cPP), PWV, and augmentation index (AIx) were higher in patients with renal dysfunction. The serum OPG level positively correlated with peripheral and central systolic blood pressure, cPP, PWV, and AIx. Conversely, the serum OPG did not correlate with FMD.
OPG and PWV are possible biomarkers of vascular dysfunction that are altered in patients with moderate renal dysfunction. Despite limitations of this study, including that it was a case-control study conducted at a single center, it has the potential, as a proof of concept, to generate the hypothesis of OPG and PWV as biomarkers of early vascular damage in this population. |
| doi_str_mv | 10.36660/abc.20240122 |
| format | Article |
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This study aimed to compare and correlate OPG values with flow-mediated dilation (FMD) and pulse wave velocity (PWV) measurements in patients in stage 3 CKD and those without renal dysfunction.
This case-control study was conducted in a specialized hypertension center in 2022. A total of 79 patients over 18 years of age participated in the study. The case group consisted of 30 patients with moderate renal dysfunction (CKD stage 3) and the control group included 49 individuals with glomerular filtration rate ≥ 60 mL/min/1.73 m2. The significance level adopted in the statistical analysis was 5%.
Central pulse pressure (cPP), PWV, and augmentation index (AIx) were higher in patients with renal dysfunction. The serum OPG level positively correlated with peripheral and central systolic blood pressure, cPP, PWV, and AIx. Conversely, the serum OPG did not correlate with FMD.
OPG and PWV are possible biomarkers of vascular dysfunction that are altered in patients with moderate renal dysfunction. Despite limitations of this study, including that it was a case-control study conducted at a single center, it has the potential, as a proof of concept, to generate the hypothesis of OPG and PWV as biomarkers of early vascular damage in this population.</description><identifier>ISSN: 1678-4170</identifier><identifier>EISSN: 1678-4170</identifier><identifier>DOI: 10.36660/abc.20240122</identifier><identifier>PMID: 39607169</identifier><language>eng ; por</language><publisher>Brazil</publisher><subject>Adult ; Aged ; Biomarkers - blood ; Blood Pressure - physiology ; Case-Control Studies ; Female ; Glomerular Filtration Rate - physiology ; Humans ; Male ; Middle Aged ; Osteoprotegerin - blood ; Pulse Wave Analysis ; Reference Values ; Renal Insufficiency, Chronic - blood ; Renal Insufficiency, Chronic - complications ; Renal Insufficiency, Chronic - physiopathology ; Statistics, Nonparametric ; Vascular Stiffness - physiology</subject><ispartof>Arquivos brasileiros de cardiologia, 2024-10, Vol.121 (11), p.e20240122</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000-0002-5487-4649 ; 0000-0001-9719-3176 ; 0000-0002-1265-1930 ; 0009-0001-6344-6099</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,864,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39607169$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matos, Thalita de Oliveira</creatorcontrib><creatorcontrib>Vitorino, Priscila Valverde de Oliveira</creatorcontrib><creatorcontrib>Orlow, Rogerio</creatorcontrib><creatorcontrib>Melo, Átila de Oliveira</creatorcontrib><creatorcontrib>Amorim, Diogo da Silva</creatorcontrib><creatorcontrib>Sousa, Gleidson Junio Oliveira</creatorcontrib><creatorcontrib>Jorgetti, Vanda</creatorcontrib><creatorcontrib>Sousa, Ana Luiza Lima</creatorcontrib><creatorcontrib>Bezerra, Rodrigo</creatorcontrib><creatorcontrib>Barroso, Weimar Kunz Sebba</creatorcontrib><title>Osteoprotegerin and Vascular Dysfunction in Patients with Stage 3 Chronic Kidney Disease and Those without Renal Dysfunction: A Case-Control Study</title><title>Arquivos brasileiros de cardiologia</title><addtitle>Arq Bras Cardiol</addtitle><description>Osteoprotegerin (OPG) is a marker of vascular calcification and cardiovascular risk in patients with chronic kidney disease (CKD).
This study aimed to compare and correlate OPG values with flow-mediated dilation (FMD) and pulse wave velocity (PWV) measurements in patients in stage 3 CKD and those without renal dysfunction.
This case-control study was conducted in a specialized hypertension center in 2022. A total of 79 patients over 18 years of age participated in the study. The case group consisted of 30 patients with moderate renal dysfunction (CKD stage 3) and the control group included 49 individuals with glomerular filtration rate ≥ 60 mL/min/1.73 m2. The significance level adopted in the statistical analysis was 5%.
Central pulse pressure (cPP), PWV, and augmentation index (AIx) were higher in patients with renal dysfunction. The serum OPG level positively correlated with peripheral and central systolic blood pressure, cPP, PWV, and AIx. Conversely, the serum OPG did not correlate with FMD.
OPG and PWV are possible biomarkers of vascular dysfunction that are altered in patients with moderate renal dysfunction. Despite limitations of this study, including that it was a case-control study conducted at a single center, it has the potential, as a proof of concept, to generate the hypothesis of OPG and PWV as biomarkers of early vascular damage in this population.</description><subject>Adult</subject><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Blood Pressure - physiology</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Glomerular Filtration Rate - physiology</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Osteoprotegerin - blood</subject><subject>Pulse Wave Analysis</subject><subject>Reference Values</subject><subject>Renal Insufficiency, Chronic - blood</subject><subject>Renal Insufficiency, Chronic - complications</subject><subject>Renal Insufficiency, Chronic - physiopathology</subject><subject>Statistics, Nonparametric</subject><subject>Vascular Stiffness - physiology</subject><issn>1678-4170</issn><issn>1678-4170</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpNkEtLw0AUhQdRrFaXbmWWblLnkcwk7krqCwsVLW7DTWbSjqQzNTNB8jf8xUat0NU9cD4-OBehC0omXAhBrqGsJoywmFDGDtAJFTKNYirJ4V4eoVPv3wlhTPLkGI14JoikIjtBXwsftNu2LuiVbo3FYBV-A191DbR41vu6s1UwzuKhe4ZgtA0ef5qwxq8BVhpznK9bZ02Fn4yyuscz4zV4_Start2QfmjXBfyiLTT7zhs8xfnARrmzoXXNoOxUf4aOami8Pt_dMVre3S7zh2i-uH_Mp_Nom4gsqginmSKU1lKoVJZZogShGkAliZYqS2MQNS1LUCJh8YABlKqKYwYpESTjfIyu_rTD-I9O-1BsjK9004DVrvMFp5xLnmaJGNDLHdqVG62KbWs20PbF_xv5N2Rrdh4</recordid><startdate>202410</startdate><enddate>202410</enddate><creator>Matos, Thalita de Oliveira</creator><creator>Vitorino, Priscila Valverde de Oliveira</creator><creator>Orlow, Rogerio</creator><creator>Melo, Átila de Oliveira</creator><creator>Amorim, Diogo da Silva</creator><creator>Sousa, Gleidson Junio Oliveira</creator><creator>Jorgetti, Vanda</creator><creator>Sousa, Ana Luiza Lima</creator><creator>Bezerra, Rodrigo</creator><creator>Barroso, Weimar Kunz Sebba</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5487-4649</orcidid><orcidid>https://orcid.org/0000-0001-9719-3176</orcidid><orcidid>https://orcid.org/0000-0002-1265-1930</orcidid><orcidid>https://orcid.org/0009-0001-6344-6099</orcidid></search><sort><creationdate>202410</creationdate><title>Osteoprotegerin and Vascular Dysfunction in Patients with Stage 3 Chronic Kidney Disease and Those without Renal Dysfunction: A Case-Control Study</title><author>Matos, Thalita de Oliveira ; Vitorino, Priscila Valverde de Oliveira ; Orlow, Rogerio ; Melo, Átila de Oliveira ; Amorim, Diogo da Silva ; Sousa, Gleidson Junio Oliveira ; Jorgetti, Vanda ; Sousa, Ana Luiza Lima ; Bezerra, Rodrigo ; Barroso, Weimar Kunz Sebba</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p569-c0319d011f76d87b95d601eaad55e7d984a6f1bbad652411faabdc442a8060933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; por</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Blood Pressure - physiology</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Glomerular Filtration Rate - physiology</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Osteoprotegerin - blood</topic><topic>Pulse Wave Analysis</topic><topic>Reference Values</topic><topic>Renal Insufficiency, Chronic - blood</topic><topic>Renal Insufficiency, Chronic - complications</topic><topic>Renal Insufficiency, Chronic - physiopathology</topic><topic>Statistics, Nonparametric</topic><topic>Vascular Stiffness - physiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matos, Thalita de Oliveira</creatorcontrib><creatorcontrib>Vitorino, Priscila Valverde de Oliveira</creatorcontrib><creatorcontrib>Orlow, Rogerio</creatorcontrib><creatorcontrib>Melo, Átila de Oliveira</creatorcontrib><creatorcontrib>Amorim, Diogo da Silva</creatorcontrib><creatorcontrib>Sousa, Gleidson Junio Oliveira</creatorcontrib><creatorcontrib>Jorgetti, Vanda</creatorcontrib><creatorcontrib>Sousa, Ana Luiza Lima</creatorcontrib><creatorcontrib>Bezerra, Rodrigo</creatorcontrib><creatorcontrib>Barroso, Weimar Kunz Sebba</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Arquivos brasileiros de cardiologia</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matos, Thalita de Oliveira</au><au>Vitorino, Priscila Valverde de Oliveira</au><au>Orlow, Rogerio</au><au>Melo, Átila de Oliveira</au><au>Amorim, Diogo da Silva</au><au>Sousa, Gleidson Junio Oliveira</au><au>Jorgetti, Vanda</au><au>Sousa, Ana Luiza Lima</au><au>Bezerra, Rodrigo</au><au>Barroso, Weimar Kunz Sebba</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Osteoprotegerin and Vascular Dysfunction in Patients with Stage 3 Chronic Kidney Disease and Those without Renal Dysfunction: A Case-Control Study</atitle><jtitle>Arquivos brasileiros de cardiologia</jtitle><addtitle>Arq Bras Cardiol</addtitle><date>2024-10</date><risdate>2024</risdate><volume>121</volume><issue>11</issue><spage>e20240122</spage><pages>e20240122-</pages><issn>1678-4170</issn><eissn>1678-4170</eissn><abstract>Osteoprotegerin (OPG) is a marker of vascular calcification and cardiovascular risk in patients with chronic kidney disease (CKD).
This study aimed to compare and correlate OPG values with flow-mediated dilation (FMD) and pulse wave velocity (PWV) measurements in patients in stage 3 CKD and those without renal dysfunction.
This case-control study was conducted in a specialized hypertension center in 2022. A total of 79 patients over 18 years of age participated in the study. The case group consisted of 30 patients with moderate renal dysfunction (CKD stage 3) and the control group included 49 individuals with glomerular filtration rate ≥ 60 mL/min/1.73 m2. The significance level adopted in the statistical analysis was 5%.
Central pulse pressure (cPP), PWV, and augmentation index (AIx) were higher in patients with renal dysfunction. The serum OPG level positively correlated with peripheral and central systolic blood pressure, cPP, PWV, and AIx. Conversely, the serum OPG did not correlate with FMD.
OPG and PWV are possible biomarkers of vascular dysfunction that are altered in patients with moderate renal dysfunction. Despite limitations of this study, including that it was a case-control study conducted at a single center, it has the potential, as a proof of concept, to generate the hypothesis of OPG and PWV as biomarkers of early vascular damage in this population.</abstract><cop>Brazil</cop><pmid>39607169</pmid><doi>10.36660/abc.20240122</doi><orcidid>https://orcid.org/0000-0002-5487-4649</orcidid><orcidid>https://orcid.org/0000-0001-9719-3176</orcidid><orcidid>https://orcid.org/0000-0002-1265-1930</orcidid><orcidid>https://orcid.org/0009-0001-6344-6099</orcidid></addata></record> |
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| ispartof | Arquivos brasileiros de cardiologia, 2024-10, Vol.121 (11), p.e20240122 |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; PubMed Central Open Access; EZB-FREE-00999 freely available EZB journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Adult Aged Biomarkers - blood Blood Pressure - physiology Case-Control Studies Female Glomerular Filtration Rate - physiology Humans Male Middle Aged Osteoprotegerin - blood Pulse Wave Analysis Reference Values Renal Insufficiency, Chronic - blood Renal Insufficiency, Chronic - complications Renal Insufficiency, Chronic - physiopathology Statistics, Nonparametric Vascular Stiffness - physiology |
| title | Osteoprotegerin and Vascular Dysfunction in Patients with Stage 3 Chronic Kidney Disease and Those without Renal Dysfunction: A Case-Control Study |
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