Polyphyllin VI: A promising treatment for prostate cancer bone metastasis

[Display omitted] •Polyphyllin VI effectively inhibits osteoclast differentiation, crucial in prostate cancer bone metastasis.•Demonstrated significant suppression of tumor cell proliferation, migration, and invasion in vitro.•Induced apoptosis and G2/M phase arrest in RM-1 prostate cancer cells.•Re...

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Veröffentlicht in:	International immunopharmacology 2025-01, Vol.144, p.113684, Article 113684
Hauptverfasser:	Feng, Yanbin, Mo, Yaomin, Zhang, Yang, Teng, Yilin, Xi, Deshuang, Zhou, Junhong, Zeng, Gaofeng, Zong, Shaohui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Apoptosis - drug effects Bone metastases Bone Neoplasms - drug therapy Bone Neoplasms - secondary Cell Differentiation - drug effects Cell Line, Tumor Cell Movement - drug effects Cell Proliferation - drug effects Humans Male Mice Osteoclast Osteoclasts - drug effects Osteoclasts - pathology Polyphyllin VI Prostate cancer Prostatic Neoplasms - drug therapy Prostatic Neoplasms - pathology RANK Ligand - metabolism Saponins - pharmacology Saponins - therapeutic use
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