Ubiquitin-specific peptidase 11 selectively interacts with and deubiquitination-dependently stabilizes diacylglycerol kinase δ to maintain cellular glucose uptake

Diacylglycerol kinase δ (DGKδ) phosphorylates diacylglycerol and converts it into phosphatidic acid. DGKδ contributes to glucose uptake as one of its cellular functions. However, detail mechanisms underlying the regulation of DGKδ protein stability remain unelucidated. Herein, we identified ubiquiti...

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Veröffentlicht in:	Biochimica et biophysica acta. Molecular cell research 2025-02, Vol.1872 (2), p.119883, Article 119883
Hauptverfasser:	Ebina, Masayuki, Miura, Yuri, Sakane, Fumio
Format:	Artikel
Sprache:	eng
Schlagworte:	Deubiquitination Diacylglycerol Kinase - genetics Diacylglycerol Kinase - metabolism Diacylglycerol kinase δ Glucose - metabolism Glucose uptake HEK293 Cells Humans Protein stability Thiolester Hydrolases - genetics Thiolester Hydrolases - metabolism Ubiquitin-specific peptidase 11 Ubiquitination
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