Transposable element 5mC methylation state of blood cells predicts age and disease

Transposable elements (TEs) are DNA sequences that expand selfishly in the genome, possibly causing severe cellular damage. While normally silenced, TEs have been shown to activate during aging. DNA 5-methylcytosine (5mC) is one of the main epigenetic modifications by which TEs are silenced and has...

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Veröffentlicht in:	Nature aging 2024-11
Hauptverfasser:	Morandini, Francesco, Lu, Jinlong Y, Rechsteiner, Cheyenne, Shadyab, Aladdin H, Casanova, Ramon, Snively, Beverly M, Seluanov, Andrei, Gorbunova, Vera
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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