Bilateral transcranial direct-current stimulation confers neuroprotection through suppression of PKM2 after mouse cerebral ischemia injury

[Display omitted] •The level of PKM2 tetramers and the activity of PKM2 are increased after cerebral ischemia injury.•Ischemia-induced increase of PKM2 activity promotes neuronal death via the suppression of PPP-dependent antioxidant capacity.•We have established a newly direct-current stimulation a...

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Veröffentlicht in:	Brain research 2025-02, Vol.1849, p.149353, Article 149353
Hauptverfasser:	Ren, Jinyang, Gao, Jingchen, Yao, Xujin, Wang, Xiyuran, Kong, Xiangyi, Lin, Tao, Wang, Hui, Ma, Wenlong, Glebov, Oleg O., Wan, Qi
Format:	Artikel
Sprache:	eng
Schlagworte:	Bilateral transcranial direct current stimulation (BtDCS) Ischemic stroke Metabolic reprogramming Neuroprotection Pyruvate kinase isoform M2 (PKM2)
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