Long-term exposure to excessive norepinephrine in the brain induces tau aggregation, neuronal death, and cognitive deficits in early tau transgenic mice

Alzheimer's disease (AD) is marked by the presence of intraneuronal neurofibrillary tangles (NFTs), which are primarily composed of hyperphosphorylated tau protein. The locus coeruleus (LC), the brain's main source of norepinephrine (NE), is one of the earliest regions to develop NFTs and...

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Veröffentlicht in:	Aging cell 2024-11, p.e14420
Hauptverfasser:	Jeong, June-Hyun, Kim, Dong Kyu, Chung, Sunwoo, Han, Jong Won, Han, Jihui, Mook-Jung, Inhee
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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